Novel plastics using renewable signal chemistry to remove bacteria in water. This project plans to develop synthetic plastic surfaces that continuously generate nitric oxide to deter the formation of biofilms. Plastic surfaces exposed to aqueous environments rapidly become covered by a film of bacteria, which can cause infection. Trace levels of generated nitric oxide can combat this problem by breaking up existing bacterial biofilms. Current research has developed plastics that continuously gen ....Novel plastics using renewable signal chemistry to remove bacteria in water. This project plans to develop synthetic plastic surfaces that continuously generate nitric oxide to deter the formation of biofilms. Plastic surfaces exposed to aqueous environments rapidly become covered by a film of bacteria, which can cause infection. Trace levels of generated nitric oxide can combat this problem by breaking up existing bacterial biofilms. Current research has developed plastics that continuously generate nitric oxide, but not for extended periods of time. This project’s approach is significant because it avoids bacterial resistance to the nitric oxide treatment. Applications of this technology may include removing biofilms from environments such as water filtration devices and consumable medical surfaces.Read moreRead less
Chiral synthetic macromolecules - control of sequence and stereochemistry. This project aims to assemble a library of novel chiral polymers mimicking natural peptides with precisely controlled primary structures using emerging synthetic technologies. A systematic investigation of these synthetic materials will provide an in-depth understanding of how sequence and stereochemistry influence chemical and physical properties. Employing rational design principles, desired functionality could be optim ....Chiral synthetic macromolecules - control of sequence and stereochemistry. This project aims to assemble a library of novel chiral polymers mimicking natural peptides with precisely controlled primary structures using emerging synthetic technologies. A systematic investigation of these synthetic materials will provide an in-depth understanding of how sequence and stereochemistry influence chemical and physical properties. Employing rational design principles, desired functionality could be optimised through the selective modification of polymer structure. These materials should be able to emulate the unique properties and functionality of natural peptides/proteins, making them invaluable for biochemical applications, such as molecular recognition and asymmetric catalysis.Read moreRead less