Synthesis of Novel Biomaterials for Drug delivery. A new UV radiation polymerisation technique utilising charge-transfer complexes is adopted for synthesising novel hydrogels, a group of biomaterials for drug delivery. This work is significant as charge-transfer complexes, pertinent to the formation of hydrogels, form copolymers within the hydrogel matrices. This eliminates using costly, yet undesirable photo-initiators (PI), thus rendering the hydrogels as cleaner (PI-free) and more economical ....Synthesis of Novel Biomaterials for Drug delivery. A new UV radiation polymerisation technique utilising charge-transfer complexes is adopted for synthesising novel hydrogels, a group of biomaterials for drug delivery. This work is significant as charge-transfer complexes, pertinent to the formation of hydrogels, form copolymers within the hydrogel matrices. This eliminates using costly, yet undesirable photo-initiators (PI), thus rendering the hydrogels as cleaner (PI-free) and more economical in production; the products present themselves as ideal treatment methods in the controlled-release of drugs, specifically targeting localised pathological sites of interest. The research findings will be invaluable to medical practices, leading to the creation of new industries in Australia.
Read moreRead less
Development of a Novel Process for the Formation of Polymer Vesicles. The project would provide an increased understanding of polymer structures, polymer-drug interactions and dense gas processing of polymers. The novel process developed would be beneficial on a manufacturing level since it dramatically reduces processing time and minimises energy requirements. The research to be conducted is leading-edge technology that will attract business from international polymer, drug and biotechnology co ....Development of a Novel Process for the Formation of Polymer Vesicles. The project would provide an increased understanding of polymer structures, polymer-drug interactions and dense gas processing of polymers. The novel process developed would be beneficial on a manufacturing level since it dramatically reduces processing time and minimises energy requirements. The research to be conducted is leading-edge technology that will attract business from international polymer, drug and biotechnology companies. The development of world-class research provides Australia with recognition as a world leader in the field and strengthens and broadens the knowledge base of Australian scientists and engineers.Read moreRead less
Feasibility Studies of Using AC Electrospraying for Biomaterials Synthesis. The proposed interdisciplinary research is anticipated to benefit workers in academia and industry as well as clinicians and patients. Given the demand for point-of-care drug delivery, micro/nano-encapsulation and biomaterials synthesis, the research will be beneficial to the pharmaceutical industry and spin-off/start-up microfluidic businesses interested in commercially developing these devices. It is intended that the ....Feasibility Studies of Using AC Electrospraying for Biomaterials Synthesis. The proposed interdisciplinary research is anticipated to benefit workers in academia and industry as well as clinicians and patients. Given the demand for point-of-care drug delivery, micro/nano-encapsulation and biomaterials synthesis, the research will be beneficial to the pharmaceutical industry and spin-off/start-up microfluidic businesses interested in commercially developing these devices. It is intended that the work will improve quality of life by advancing biomaterials technology and by making medical treatment more readily accessable, portable and more efficient. For patients, the proposed drug delivery device can help prevent sudden initial bursts of dose during administration, which could potentially have fatal consequences.Read moreRead less
Composite biomaterials for modulation of dermal fibroblast function. The successful outcome of this research will revolutionize the way scars are treated for the large number of people who suffer burns and even minor trauma that leads to disfigurement. By using advanced chemical synthesis, biochemical analysis, cell biology and polymer materials science, an intelligent gel sheet will be devised that is able to control the formation of scar tissue and also reduce the effect of existing scars. Thi ....Composite biomaterials for modulation of dermal fibroblast function. The successful outcome of this research will revolutionize the way scars are treated for the large number of people who suffer burns and even minor trauma that leads to disfigurement. By using advanced chemical synthesis, biochemical analysis, cell biology and polymer materials science, an intelligent gel sheet will be devised that is able to control the formation of scar tissue and also reduce the effect of existing scars. This will produce improved quality of life for sufferers of severe scarring and have major economic benefits in reduced health costs. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668496
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
Facility for Structural Analysis of Bio-Molecular Complexes and Self Assembly. The research will advance our understanding of biological systems and this new knowledge will lead to innovative approaches to healthy living (therapeutics, drugs). We will have a better understanding of genetic diversity in the microbial environment and of biological adaptation that provides a foundation for environmental management as well as opportunities for biotechnology development. Studies of self-assembling ....Facility for Structural Analysis of Bio-Molecular Complexes and Self Assembly. The research will advance our understanding of biological systems and this new knowledge will lead to innovative approaches to healthy living (therapeutics, drugs). We will have a better understanding of genetic diversity in the microbial environment and of biological adaptation that provides a foundation for environmental management as well as opportunities for biotechnology development. Studies of self-assembling systems will advance fundamental and applied research in biology, as well as our understanding of the forces driving self-assembly that can lead to the development of new materials. The facility will provide unique opportunities for collaboration with biotechnology and biomedical industry partners.Read moreRead less