Validating And Optimising The Analysis Of Magnetic Resonance Physiology Data
Funder
National Health and Medical Research Council
Funding Amount
$91,725.00
Summary
Combined electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) is used to detect the anatomical areas in the brain that show electrical activity. Several centres worldwide use this technique to localise the seizure focus in patients with epilepsy. However, there is a lack of validation of the currently applied techniques. Current analysis methods have been developed and validated for other fMRI paradigms, such as motor tasks. It is not known whether the same principles ar ....Combined electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) is used to detect the anatomical areas in the brain that show electrical activity. Several centres worldwide use this technique to localise the seizure focus in patients with epilepsy. However, there is a lack of validation of the currently applied techniques. Current analysis methods have been developed and validated for other fMRI paradigms, such as motor tasks. It is not known whether the same principles are applicable and optimal for fMRI-EEG data. The proposed project aims at validating and optimising the analysis strategies for fMRI-EEG data.Read moreRead less
E-DADS: Early Detection Of Alzheimer’s Disease Subtypes
Funder
National Health and Medical Research Council
Funding Amount
$488,725.00
Summary
Alzheimer's disease manifests differently in different people. Some people may get the disease at younger ages or they may progress in the disease much faster than others. This grant aims to use large amounts of data from around the world to understand why these differences exist. This knowledge will be converted into a tool where data from a specific individual can be used to forecast if and when they will get the disease and how fast that disease will progress and how it could be prevented.
If Australia’s health system is to benefit from the digital revolution, we need much more than new technology; we need research evidence, skills and workforce to translate these advances into effective working health services. The Centre for Research Excellence in Digital Health brings together for the first time the major Australian centres of e-health research to tackle the fundamental challenges that impede the creation of truly safe, efficient and effective digital health services.
The Use Of Real-World Evidence To Support Regulatory And Reimbursement Decisions
Funder
National Health and Medical Research Council
Funding Amount
$91,538.00
Summary
Traditionally, medicines are studied extensively in clinical trials before they are widely available. More recently, some medicines have been allowed to enter the market without complete data on their benefits and risks. This means that these issues can only be studied once a medicine is on the market and used in routine clinical practice; this is referred to as real-world evidence. This research evaluates if this evidence is sufficient to prove that a medicine is safe and that it works
Novel Pathways Toward Improving Relapse Prediction In Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Relapse is a devastating problem in schizophrenia and our ability to predict when it occurs is still relatively poor. This project seeks to investigate a new method of tracking relapse by measuring speech and symptom changes across time. This novel design is supported by advanced data modelling methods to provide sensitive predictive ability. This project has the potential to significantly improve relapse prediction in schizophrenia and so support and increase beneficial outcomes for patients
An Indigenous Australian Reference Genome: Indigenous Inclusion In The Benefits Of Genomic Medicine
Funder
National Health and Medical Research Council
Funding Amount
$1,428,508.00
Summary
This project will establish an Indigenous Australian reference genome (the NCIGrg) within the National Centre for Indigenous Genomics (NCIG) using advanced genome sequencing technologies and data analytics and evaluate its research and clinical utility. The NCIGrg will be cornerstone of future genomic research and its clinical application in Indigenous communities. It will underpin NCIG’s commitment to ensuring that Indigenous Australians are included in the benefits of genomic medicine.
Building Capacity In Policy Relevant, Quantitative, Social Analysis And Research In Indigenous Health
Funder
National Health and Medical Research Council
Funding Amount
$2,449,933.00
Summary
This program aims to develop a critical mass of Indigenous and non-Indigenous researchers who combine advanced quantitative skills with a keen understanding of the needs of policy makers. The program will develop researchers who are able to undertake the type of research and critical analysis that is necessary to improve the evidence base for Indigenous health and social
Development Of A Unified List Of Drugs Associated With Drug-induced Cognitive Impairment
Funder
National Health and Medical Research Council
Funding Amount
$443,573.00
Summary
This research will develop a comprehensive list of drugs probably impairing cognition. These drugs will be identified from a large spontaneous reporting system in combination with those from published literature. The association of identified drugs and cognitive impairment will be tested using prescription sequence symmetry analyses in Pharmaceutical Benefits Scheme claims database and validated through formal epidemiological studies in Australian ongoing longitudinal population-based cohorts.