Neurological Manifestations Of Experimental Neuronal Voltage-gated Potassium Channel Autoimmunity.
Funder
National Health and Medical Research Council
Funding Amount
$65,148.00
Summary
Antibodies against neuronal voltage-gated potassium channels (VGKC) are seen in various neurological illnesses, most commonly epilepsy and memory loss. The role of VGKC antibodies in the development of brain disease will be studied by immunizing rabbits against VGKC and transferring these antibodies to mice.
Studies On Induction Of Antigen Specific T Regulatory Cells To Control Autoimmunity
Funder
National Health and Medical Research Council
Funding Amount
$353,033.00
Summary
The immune system has natural control mechanisms, called regulatory cells. Our group was the first in the world to correctly identify these cells. There is now a world-wide interest in these cells as they can prevent unwanted immune mediated injury. In autoimmune diseases such as multiple sclerosis, regulatory cells can prevent relapse and progression. This project will identify ways of producing potent specific regulatory cells to control multiple sclerosis and other debilitating neurological d ....The immune system has natural control mechanisms, called regulatory cells. Our group was the first in the world to correctly identify these cells. There is now a world-wide interest in these cells as they can prevent unwanted immune mediated injury. In autoimmune diseases such as multiple sclerosis, regulatory cells can prevent relapse and progression. This project will identify ways of producing potent specific regulatory cells to control multiple sclerosis and other debilitating neurological diseases.Read moreRead less
Using Genomics To Understand Psychiatric Disorders
Funder
National Health and Medical Research Council
Funding Amount
$772,490.00
Summary
The last five years have seen unprecedented discovery of DNA risk factors for psychiatric disorders. In my Fellowship I will combine analyses of genomic data with development of new statistical methodologies to contribute to my vision that application of genomics methods in psychiatry will continue to catalyze more discoveries of the causes of these complex genetic disorders.
Craig Anderson is a clinician-scientist, with specialist training in neurology and geriatrics, and an internationally-recognised epidemiologist and clinical trialist researcher. His work is dedicated to generating the highest quality evidence to improve the prevention and treatment of stroke and other neurological diseases related to ageing.
Gene Discovery And Functional Insights For Neurological And Retinal Disorders
Funder
National Health and Medical Research Council
Funding Amount
$2,163,220.00
Summary
Understanding the genetic drivers of disease is key for the development of disease therapies. Determination of the causal genetic variants in a disorder can be used for future diagnosis, prognostication, and personalised treatment. We have previously identified ~20 novel genes and developed new methods providing genomic diagnoses for 1000s of individuals. In the next five years I will make significant advances in our understanding of what causes diseases such as epilepsy, ataxia and dementia.