Disruptive approaches to biological sensing. Optical fibre-based biosensors have the potential to transform our ability to monitor our environment, protect our nation's assets and safeguard our citizens, and to offer improved clinical diagnostics and food quality control by creating tools that can detect biomolecules in real-time within complex samples. To fulfil this mission, we propose to develop new fibre-based sensing architectures for sensing biomolecules that have the potential to be sensi ....Disruptive approaches to biological sensing. Optical fibre-based biosensors have the potential to transform our ability to monitor our environment, protect our nation's assets and safeguard our citizens, and to offer improved clinical diagnostics and food quality control by creating tools that can detect biomolecules in real-time within complex samples. To fulfil this mission, we propose to develop new fibre-based sensing architectures for sensing biomolecules that have the potential to be sensitive, selective, fast and compact.Read moreRead less
Transformational diagnostics. Australia has established world-leading capabilities in optical fibres and surface science that, when brought together, have the potential to transform applications that require non-invasive, real-time and/or portable biological detection tools. We propose a novel and ambitious suite of projects that bring together these capabilities with experts in reproductive health, forensics and explosives to solve pressing problems in each of these areas that have the promise ....Transformational diagnostics. Australia has established world-leading capabilities in optical fibres and surface science that, when brought together, have the potential to transform applications that require non-invasive, real-time and/or portable biological detection tools. We propose a novel and ambitious suite of projects that bring together these capabilities with experts in reproductive health, forensics and explosives to solve pressing problems in each of these areas that have the promise to develop into new industries for Australia as well as to explore rich science opportunities at the boundaries of these disciplines.Read moreRead less
Nanoimaging the cellular architecture of the malaria parasite, Plasmodium falciparum. The immediate benefit of this work will be in the understanding and treatment of malaria - a disease that kills approximately 1 million children annually. The ability to image the three-dimensional structure of cells at high resolution will allow us to ask fundamental questions about the cellular architecture of the malaria parasite and to design novel antimalarial strategies. By developing new methods for cor ....Nanoimaging the cellular architecture of the malaria parasite, Plasmodium falciparum. The immediate benefit of this work will be in the understanding and treatment of malaria - a disease that kills approximately 1 million children annually. The ability to image the three-dimensional structure of cells at high resolution will allow us to ask fundamental questions about the cellular architecture of the malaria parasite and to design novel antimalarial strategies. By developing new methods for correlating structure and elemental location, the work in this proposal will offer a new paradigm for the study of cellular function and disease. This represents an important advance in the suite of investigative tools available to the biotechology sector and will see a corresponding improvement in our understanding of a wide range of disease states.Read moreRead less
Precipitation-groundwater interactions over eastern Australia: climate change impacts at multiple scales. Most surface water in the Murray-Darling Basin is used for agricultural activity, and groundwater extraction is accelerating. We cannot yet predict how these water resources will be affected by climate change, partly because Australian climate models do not represent key interactions between small and large scale rainfall changes, and interactions between ground water, the land surface and t ....Precipitation-groundwater interactions over eastern Australia: climate change impacts at multiple scales. Most surface water in the Murray-Darling Basin is used for agricultural activity, and groundwater extraction is accelerating. We cannot yet predict how these water resources will be affected by climate change, partly because Australian climate models do not represent key interactions between small and large scale rainfall changes, and interactions between ground water, the land surface and the atmosphere. This project will produce the first climate simulations that explicitly include these interactions. This will allow a better understanding of future changes to groundwater resources. This understanding will help us plan ahead, and enable new research to help Australia maintain food security in an uncertain future.Read moreRead less
Supporting early science from the Murchison Widefield Array - a Square Kilometre Array (SKA) pathfinder telescope. The Murchison Widefield Array (MWA) is likely to be the first operational pathfinder for the $2.5 billion Square Kilometre Array (SKA) on one of the two candidate SKA sites - the Murchison Radioastronomy Observatory (MRO) in Western Australia. The MWA will therefore generate large volumes of scientific data before 2012, the expected date of the international decision that will dete ....Supporting early science from the Murchison Widefield Array - a Square Kilometre Array (SKA) pathfinder telescope. The Murchison Widefield Array (MWA) is likely to be the first operational pathfinder for the $2.5 billion Square Kilometre Array (SKA) on one of the two candidate SKA sites - the Murchison Radioastronomy Observatory (MRO) in Western Australia. The MWA will therefore generate large volumes of scientific data before 2012, the expected date of the international decision that will determine whether Australia or South Africa is to host the SKA. The early science results from the MWA will showcase the excellence of the Australian site for radio astronomy and play a significant strategic role in Australia's bid to attract the SKA, as an international mega-science project to Australia, with its benefits to Australian science, industry and society.Read moreRead less
Supporting early science from the Murchison Widefield Array - a Square Kilometre Array (SKA) pathfinder telescope. The Murchison Widefield Array (MWA) is likely to be the first operational pathfinder for the $2.5 billion Square Kilometre Array (SKA) on one of the two candidate SKA sites - the Murchison Radioastronomy Observatory (MRO) in Western Australia. The MWA will therefore generate large volumes of scientific data before 2012, the expected date of the international decision that will dete ....Supporting early science from the Murchison Widefield Array - a Square Kilometre Array (SKA) pathfinder telescope. The Murchison Widefield Array (MWA) is likely to be the first operational pathfinder for the $2.5 billion Square Kilometre Array (SKA) on one of the two candidate SKA sites - the Murchison Radioastronomy Observatory (MRO) in Western Australia. The MWA will therefore generate large volumes of scientific data before 2012, the expected date of the international decision that will determine whether Australia or South Africa is to host the SKA. The early science results from the MWA will showcase the excellence of the Australian site for radio astronomy and play a significant strategic role in Australia's bid to attract the SKA, as an international mega-science project to Australia, with its benefits to Australian science, industry and society.Read moreRead less
Towards operational monitoring of key climate parameters from synthetic aperture radar. Agricultural productivity is a major contributor to the Australian economy, but is experiencing significant stress in response to climate change. Moreover, soil moisture controls vegetation dynamics that contribute to carbon storage, atmospheric processes leading to severe weather, and runoff generation processes leading to floods and runoff yield from urban water storage catchments. Consequently, high reso ....Towards operational monitoring of key climate parameters from synthetic aperture radar. Agricultural productivity is a major contributor to the Australian economy, but is experiencing significant stress in response to climate change. Moreover, soil moisture controls vegetation dynamics that contribute to carbon storage, atmospheric processes leading to severe weather, and runoff generation processes leading to floods and runoff yield from urban water storage catchments. Consequently, high resolution time-series information on soil moisture and vegetation status from space represents a powerful tool for understanding climate change impacts on Australia. It is therefore imperative that products be developed specifically for the Australian environment to take full advantage of radar data from satellites.Read moreRead less