Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
Inhibition Of IFN-?/? By Human Metapneumovirus And The Induction Of Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$605,251.00
Summary
The newly isolated human metapneumovirus (hMPV) causes significant respiratory illness in infants, young children and the elderly. The virus can persist long-term and may predispose individuals to chronic lung disease. This proposal aims to determine the mechanisms by which hMPV infection causes respiratory disease, with a view to improving treatments and preventing disease.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Discovery Early Career Researcher Award - Grant ID: DE140101770
Funder
Australian Research Council
Funding Amount
$327,841.00
Summary
Secularism and Philosophy: The Challenge of Spinozism. With the resurgence of religious conflict throughout the world, the question of secularism has acquired renewed importance. Nowhere has the plausibility of a secular worldview been more rigorously debated than within the history of philosophy, and no philosopher has aroused more controversy on this subject than Benedict de Spinoza (1632-1677). This project will result in the first history of Spinozism's pivotal role in the history of secular ....Secularism and Philosophy: The Challenge of Spinozism. With the resurgence of religious conflict throughout the world, the question of secularism has acquired renewed importance. Nowhere has the plausibility of a secular worldview been more rigorously debated than within the history of philosophy, and no philosopher has aroused more controversy on this subject than Benedict de Spinoza (1632-1677). This project will result in the first history of Spinozism's pivotal role in the history of secularism, focusing on three distinct episodes of philosophical conflict generated by Spinoza's thought from the late eighteenth century to the present. The study will make clear that secularism is not simply a social and political phenomenon, but a philosophical conundrum, thus far irresolvable.Read moreRead less
Plant use at the dawn of agriculture in central Anatolia. The project will increase collaboration with researchers in the UK, and Turkish archaeological authorities. It will refine our understanding of the process, rate and direction of agricultural origins in Western Asia and improve Australia's profile in origins of agriculture research. It will increase Australia's knowledge base about other regions and help to consolidate and promote archaeobotany/archaeological science in Australia's resear ....Plant use at the dawn of agriculture in central Anatolia. The project will increase collaboration with researchers in the UK, and Turkish archaeological authorities. It will refine our understanding of the process, rate and direction of agricultural origins in Western Asia and improve Australia's profile in origins of agriculture research. It will increase Australia's knowledge base about other regions and help to consolidate and promote archaeobotany/archaeological science in Australia's research community.Read moreRead less
Pro-Fluorescent Aryl Nitroxides: New Probes for Polymer Lifetime and Kinetics Research. Internal aryl rings present in novel probes developed for this project impart fluorescence which is efficiently and internally quenched by the presence of a paramagnetic nitroxide group. Scavenging of radicals by the nitroxide however "switches on" the fluorescence and this enables powerful new fluorescence-based detection levels for the technique of nitroxide free radical scavenging. Such sensitivity is a ....Pro-Fluorescent Aryl Nitroxides: New Probes for Polymer Lifetime and Kinetics Research. Internal aryl rings present in novel probes developed for this project impart fluorescence which is efficiently and internally quenched by the presence of a paramagnetic nitroxide group. Scavenging of radicals by the nitroxide however "switches on" the fluorescence and this enables powerful new fluorescence-based detection levels for the technique of nitroxide free radical scavenging. Such sensitivity is applicable to polymerization kinetics studies, as well as providing new means for the determination of materials lifetimes. The development of pro-fluorescent markers as indicators for polymer degradation would be a significant outcome for materials where component failure has a major negative impact.Read moreRead less
Non-equilibrium material phases. This project aims to synthesise and characterise exotic materials produced in the laboratory under conditions that replicate those inside planets and stars. Highly non-equilibrium processing methods are needed to find entirely new material forms of elements and compounds created under extreme pressure and temperature. The project will use its laser-based synthesis method to explore and understand the non-equilibrium pathways and develop new materials. Understandi ....Non-equilibrium material phases. This project aims to synthesise and characterise exotic materials produced in the laboratory under conditions that replicate those inside planets and stars. Highly non-equilibrium processing methods are needed to find entirely new material forms of elements and compounds created under extreme pressure and temperature. The project will use its laser-based synthesis method to explore and understand the non-equilibrium pathways and develop new materials. Understanding how these materials form could lead to the next materials revolution. This research will lead to materials that industry sectors can exploit for commercial benefits.Read moreRead less
Improved Indigenous population projections for policy and planning. This project will use a range of methods to understand the population dynamics of the Australian Aboriginal and Torres Strait Islander (Indigenous) population. This information will allow policy makers to plan and target resources and help Indigenous organisations understand what is happening to the population in their communities.