Antagonist Of Corticotrophin Releasing Hormone As Therapeutic Agents For The Prevention Of Premature Birth In Humans
Funder
National Health and Medical Research Council
Funding Amount
$376,650.00
Summary
In developed countries the most common cause of the death of a newborn baby is premature delivery. Pre-term delivery remains the greatest cause of neonatal mortality in the western world and a major consumer of health dollars (approx. $5-7B per year in the US alone). However, a delay in the onset of labour from 20 to 25 weeks has been shown to result in a 55% greater probability of infant survival (550 fewer deaths per 1000). This project will allow: The development of new drugs that will allow ....In developed countries the most common cause of the death of a newborn baby is premature delivery. Pre-term delivery remains the greatest cause of neonatal mortality in the western world and a major consumer of health dollars (approx. $5-7B per year in the US alone). However, a delay in the onset of labour from 20 to 25 weeks has been shown to result in a 55% greater probability of infant survival (550 fewer deaths per 1000). This project will allow: The development of new drugs that will allow the extension of pregnancy term The development of protocols that will in turn reduce neonatal mortality. Additionally we believe that these new agents will be useful in preventing the onset of labour after fetal surgery. Currently there are no effective treatments capable of substantially changing delivery dates. Available therapeutics delay the onset of labour, at best, 24 hours. However, recent exciting results from our laboratories show that rising concentrations of the placental peptide Corticotrophin Releasing Hormone (CRH) are associated with the onset of labour. Further, we have also delayed the onset of labour in pregnant sheep by infusing a relatively insoluble CRH antagonist into the sheep fetus. Labour commenced ONLY AFTER the drug was withdrawn from the mother. This project builds upon an interdisciplinary team: medicinal chemists, molecular modellers, pharmacologists and endocrinologists, to further develop an exciting Australian discovery. Successful completeion of this research will, for the first time, allow the control of pregnancy duration MAXIMISING the benefits to mother and child, reducing mortality and later life morbidities typically associated with premature birth.Read moreRead less
Celebrate. Remember. Fight Back. Episodic Volunteering for Non-Profits. This project seeks to improve the policy and practice of volunteer involvement in the non-profit sector. Non-profit organisations rely on volunteers, and their capacity to deliver vital community services is threatened by the decrease in long-term, continuous volunteering and increase in episodic (short-term, flexible) volunteering. The interdisciplinary project aims to use mixed methods (qualitative interviews and quantitat ....Celebrate. Remember. Fight Back. Episodic Volunteering for Non-Profits. This project seeks to improve the policy and practice of volunteer involvement in the non-profit sector. Non-profit organisations rely on volunteers, and their capacity to deliver vital community services is threatened by the decrease in long-term, continuous volunteering and increase in episodic (short-term, flexible) volunteering. The interdisciplinary project aims to use mixed methods (qualitative interviews and quantitative surveys) and multiple perspectives (volunteers and staff who manage them) to develop an episodic volunteering definition; to explore the economic and social impact of episodic volunteering, and to develop a theoretical model of volunteer retention. The findings are intended to provide an evidence base and recommendations for non-profit sector policy and practice.Read moreRead less
Markets, migration and the work of care in Australia. The objective of this project is to strengthen the conceptual foundations for social policy in the critical domains of aged care and child care. Projected child care and aged care labour shortages and shifts in government policy towards consumer-directed provision, including in-home care, have intensified calls for increased care migration in Australia. Yet the links between care markets and migration, and their consequences for the provision ....Markets, migration and the work of care in Australia. The objective of this project is to strengthen the conceptual foundations for social policy in the critical domains of aged care and child care. Projected child care and aged care labour shortages and shifts in government policy towards consumer-directed provision, including in-home care, have intensified calls for increased care migration in Australia. Yet the links between care markets and migration, and their consequences for the provision of care and the care workforce are poorly understood in the Australian context. The project aims to explain the links between care policies, employment regulation and migration in cross-national perspective, generating new analytical insights and strengthening the evidence base for policy.Read moreRead less
Increasing innovation and flexibility in social service delivery. This project will use a comparative methodology to investigate how contracted social services require careful regulation to ensure service effectiveness and improved organisational capacity. The outcome will include a practice model for understanding the relationship between regulation, contract structure and forms of service delivery innovation.
Lost in Transition: supporting young people with complex support needs. This project seeks to improve the lives of young people with complex support needs who experience overlapping forms of disadvantage. It intends to investigate how best to support their frequent transitions between services, institutions and care environments. These transitions are particularly problematic for this group, and if poorly supported, have significant social and economic costs. The project aims to analyse early li ....Lost in Transition: supporting young people with complex support needs. This project seeks to improve the lives of young people with complex support needs who experience overlapping forms of disadvantage. It intends to investigate how best to support their frequent transitions between services, institutions and care environments. These transitions are particularly problematic for this group, and if poorly supported, have significant social and economic costs. The project aims to analyse early life transitions and the supports available and to suggest best practice for transition support and a framework for how to track transitions using existing data. Intended outcomes will inform policy and practice in how best to invest in supports for young people with complex needs as they make multiple transitions.Read moreRead less
Job quality and care quality in aged care. The project aims to investigate how job quality and the quality of care are linked in residential and community-based aged care services. Population ageing and fewer informal carers place pressure on aged care provision across the OECD There is little understanding, at either the policy or workplace levels, of how the quality of aged care jobs affects the viability and quality of that provision. The project expects to improve knowledge about how job qua ....Job quality and care quality in aged care. The project aims to investigate how job quality and the quality of care are linked in residential and community-based aged care services. Population ageing and fewer informal carers place pressure on aged care provision across the OECD There is little understanding, at either the policy or workplace levels, of how the quality of aged care jobs affects the viability and quality of that provision. The project expects to improve knowledge about how job quality affects aged care quality; and identify care markets, policy regimes and work organisation that best support sustainable quality aged care.Read moreRead less
Improving contact between children in out-of-home care and their birth parents: developing and trialling a contact intervention. There is little evidence on how to best manage contact between the 37,648 children in care nationally and their birth parents. The aim of this project is to develop and trial a new model of contact which will reduce distress, improve children's relationships with their birth parents and increase successful reunifications in the long term.
Effective Decision Making Support for People with Cognitive Disability. This project aims to produce and test evidence-based education resources that boost the ability of supporters of people with cognitive disability to put the supported person’s own desires and values at the centre of decisions, as required by treaty obligations and best practice. The project aims to develop innovative education resources, and to then investigate the impact of the resources on the practices of decision-making ....Effective Decision Making Support for People with Cognitive Disability. This project aims to produce and test evidence-based education resources that boost the ability of supporters of people with cognitive disability to put the supported person’s own desires and values at the centre of decisions, as required by treaty obligations and best practice. The project aims to develop innovative education resources, and to then investigate the impact of the resources on the practices of decision-making supporters and the person being supported in a randomised control trial in three jurisdictions. The anticipated outcome is a demonstrably effective capacity-building tool, able to cater for all types of cognitive disabilities and the full spectrum of support contexts from guardianship to informal support.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100390
Funder
Australian Research Council
Funding Amount
$392,371.00
Summary
Urban inequality: The initiation and preservation of spatial privilege in Australia's elite suburbs. Increased spatial inequality in Australian cities since the 1970s has seen rising wealth in the wealthiest suburbs and increased poverty in the poorest. Investigating the drivers of such polarisation, this project will innovate by focusing on the wealthiest suburbs of Sydney and Melbourne. It will measure inequalities in access to services and investigate how affluent communities mobilise their f ....Urban inequality: The initiation and preservation of spatial privilege in Australia's elite suburbs. Increased spatial inequality in Australian cities since the 1970s has seen rising wealth in the wealthiest suburbs and increased poverty in the poorest. Investigating the drivers of such polarisation, this project will innovate by focusing on the wealthiest suburbs of Sydney and Melbourne. It will measure inequalities in access to services and investigate how affluent communities mobilise their financial means, family and social networks and negotiation skills to draw in investment in infrastructure and services. This project’s results will advance international analytical knowledge of urban dynamics and will inform planning and policy strategies to achieve more equitable distribution of services and infrastructure in metropolitan areas.Read moreRead less
Facilitating Capacity Building in the Australian Not-For-Profit Sector through Improved Work Learning. This project aims to investigate how both formal and informal work learning can improve the governance, leadership, and management capacity of not-for-profit organisations (NFPs). The research aims to identify key competencies, and chart the needs, opportunities, preferences, and barriers to develop them on a national scale. Organisational mechanisms under managerial control are further examine ....Facilitating Capacity Building in the Australian Not-For-Profit Sector through Improved Work Learning. This project aims to investigate how both formal and informal work learning can improve the governance, leadership, and management capacity of not-for-profit organisations (NFPs). The research aims to identify key competencies, and chart the needs, opportunities, preferences, and barriers to develop them on a national scale. Organisational mechanisms under managerial control are further examined to understand what facilitates work learning within NFPs. Findings aims to inform theory, practice and policy about professional development and capacity building to enhance NFPs’ ability to make a strong social impact. Outcomes aim to significantly strengthen Australia’s social and economic fabric by building effectiveness within the critical NFP sector.Read moreRead less