Molecular foundations for essential fine tuning of regulatory signals in healthy heart function. This project addresses the important question of how heart muscle contraction is regulated through studies of the dynamic molecular assemblies that constitute muscle. The structural data obtained will provide a critical foundation for medical researchers investigating genetically-linked heart disease.
Discovery Early Career Researcher Award - Grant ID: DE120102556
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The influence of crosstalk between protein post-translational modifications on the propagation of molecular signals. The ability of a cell to respond appropriately to its surroundings is a result of interactions between proteins and chemical modifiers termed post-translational modifications (PTM). This project will show how PTM interactions (competition/ cooperation) influence cellular outcomes in response to changes in the environment.