Discovery Early Career Researcher Award - Grant ID: DE160101394
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Early developmental influences on neocortical organisation. This project seeks to identify the influence of preceding developmental stages on the correct formation of the brain. Development is a sequence of transformations where every stage depends on the outcome of previous stages. The project intends to examine how the early sensory periphery, early-born brain circuits, and intrinsic neuronal interactions affect the subsequent organisation of the cerebral cortex – a mammal-specific brain regio ....Early developmental influences on neocortical organisation. This project seeks to identify the influence of preceding developmental stages on the correct formation of the brain. Development is a sequence of transformations where every stage depends on the outcome of previous stages. The project intends to examine how the early sensory periphery, early-born brain circuits, and intrinsic neuronal interactions affect the subsequent organisation of the cerebral cortex – a mammal-specific brain region responsible for perception, motor planning and cognition. It expects to provide novel mechanistic and conceptual insights into the process of normal brain development and more general biological phenomena, such as development and evolution. It may also provide insights into several genetic and non-genetic causes of brain malformations.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347607
Funder
Australian Research Council
Funding Amount
$306,000.00
Summary
FishWorks - collaborative infrastructure for zebrafish research. Zebrafish have emerged as a powerful and cost-effective animal model for studying development, biology, and disease. FishWorks represents a large-scale co-operative initiative to develop state-of-the-art zebrafish housing, manipulation, genomics and screening infrastructure in Australia. This will both support and further enhance a core group of high quality researchers to engage in cutting-edge research in areas of acknowledged ex ....FishWorks - collaborative infrastructure for zebrafish research. Zebrafish have emerged as a powerful and cost-effective animal model for studying development, biology, and disease. FishWorks represents a large-scale co-operative initiative to develop state-of-the-art zebrafish housing, manipulation, genomics and screening infrastructure in Australia. This will both support and further enhance a core group of high quality researchers to engage in cutting-edge research in areas of acknowledged expertise as well as priority within their respective institutions. In addition, it will facilitate wide-ranging collaborative arrangements to further develop and exploit this research area.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561030
Funder
Australian Research Council
Funding Amount
$441,100.00
Summary
Developmental Imaging Facility. This application seeks to establish a facility to undertake expression profiling in vertebrate tissues on a genomic scale and at the highest resolution. Undertaking large scale projects of this nature requires specialised robotics and dedicated infrastructure for microscopy and tissue preparation. This facility will be the first of its type in Australia will permit researchers to perform genomic scale in situ screens, many as part of large international initiative ....Developmental Imaging Facility. This application seeks to establish a facility to undertake expression profiling in vertebrate tissues on a genomic scale and at the highest resolution. Undertaking large scale projects of this nature requires specialised robotics and dedicated infrastructure for microscopy and tissue preparation. This facility will be the first of its type in Australia will permit researchers to perform genomic scale in situ screens, many as part of large international initiatives in developmental and cellular biology. This large-scale, high-resolution expression profiling infrastructure is required to maintain international competitiveness and will dramatically improve our gene discovery, functional assessment and understanding of vertebrate development.Read moreRead less
Defining the earliest events in lymphatic vasculature formation from veins. Vascular system development is one of the earliest events that occurs in the embryo. The entire lymphatic vascular system forms from the embryo’s early veins. This project aims to define the earliest molecular and cellular changes essential to form an entire second vessel network from just a few precursor cells in the embryo. The project aims to utilise zebrafish and mouse embryos to greatly expand knowledge in the forma ....Defining the earliest events in lymphatic vasculature formation from veins. Vascular system development is one of the earliest events that occurs in the embryo. The entire lymphatic vascular system forms from the embryo’s early veins. This project aims to define the earliest molecular and cellular changes essential to form an entire second vessel network from just a few precursor cells in the embryo. The project aims to utilise zebrafish and mouse embryos to greatly expand knowledge in the formation of this essential vertebrate tissue. Ultimately, this is expected to provide new knowledge in stem and precursor cell differentiation, the evolution of complex organ systems and tissue formation. Outcomes may impact on future biotechnology in the areas of tissues engineering, stem cell differentiation and regeneration.Read moreRead less
The virtual human knee. This project aims to investigate the Virtual Human Knee (VHK) which provides a baseline knowledge about knee mechanics in healthy individuals and a tool for studying knee mechanics in silico. The new knowledge can be used for identifying individuals most at risk for injury, developing solutions for preventing injury and for assessing knee reconstruction and implantation methods. As such, VHK will mitigate the burden of knee injury to Australia and worldwide by progressing ....The virtual human knee. This project aims to investigate the Virtual Human Knee (VHK) which provides a baseline knowledge about knee mechanics in healthy individuals and a tool for studying knee mechanics in silico. The new knowledge can be used for identifying individuals most at risk for injury, developing solutions for preventing injury and for assessing knee reconstruction and implantation methods. As such, VHK will mitigate the burden of knee injury to Australia and worldwide by progressing disciplines including anatomy, bio-mechanics, sport science, rehabilitation, surgery and medical devices.Read moreRead less
Improving the efficiency of bovine oocyte maturation in vitro. For the dairy and beef industries, the hundreds of eggs (oocytes) in a high value cow's ovary that fail to produce a pregnancy are a wasted genetic resource. A key technology to unlocking this resource is in vitro maturation of oocytes, but the process is inefficient. One possible cause is that the current approaches to maturing oocytes in vitro do not adequately mimic the natural process in vivo. We will design new systems to matu ....Improving the efficiency of bovine oocyte maturation in vitro. For the dairy and beef industries, the hundreds of eggs (oocytes) in a high value cow's ovary that fail to produce a pregnancy are a wasted genetic resource. A key technology to unlocking this resource is in vitro maturation of oocytes, but the process is inefficient. One possible cause is that the current approaches to maturing oocytes in vitro do not adequately mimic the natural process in vivo. We will design new systems to mature cow oocytes in vitro by altering the chemical composition of maturation medium, thus improving the efficiency of laboratory embryo production and related technologies.Read moreRead less
A Pragmatic Randomised Clinical Trial Of Nicotine Vaporisers Added To Smoking Cessation Treatment For Priority Populations Living With Comorbidities
Funder
National Health and Medical Research Council
Funding Amount
$1,499,145.00
Summary
Smoking is a leading cause of early death for people with certain health conditions because they are more likely to smoke and are also at greater risk of tobacco-related disease. This clinical trial will test whether encouraging people living with Hepatitis C Virus, people on opiate substitution therapy and people living with HIV who smoke to use nicotine vaporisers long-term, in addition to current smoking cessation treatments, will help them to stay abstinent from smoking.
ARACY/ARC/NHMRC Research Network: Future Generation. Research across a range of disciplines is urgently needed to understand the complexity of pathways contributing to the healthy development of children and young people in modern societies like Australia and to develop effective strategies to improve them. Given our economic prosperity and the level of knowledge about human development, it is profoundly disappointing that many child and youth problems are increasing, creating a crisis in servi ....ARACY/ARC/NHMRC Research Network: Future Generation. Research across a range of disciplines is urgently needed to understand the complexity of pathways contributing to the healthy development of children and young people in modern societies like Australia and to develop effective strategies to improve them. Given our economic prosperity and the level of knowledge about human development, it is profoundly disappointing that many child and youth problems are increasing, creating a crisis in services. This application brings together a highly talented network of researchers to work collaboratively and innovatively with policy makers and those providing services, to enable both new knowledge and implementation of what we already know, to enhance children's futures.Read moreRead less
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revol ....ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revolutionizing diagnosis and therapy in many diseases. The CoE will be the focus of bio-nano research activity in Australia, uniting universities, research agencies, institutes and companies. The expected outcomes are better diagnostic and therapeutic tools designed via an enhanced understanding of the bio-nano-interface.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100057
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
A high-resolution X-ray microtomography system. This project aims to establish a Scanco microCT 50 high resolution X-Ray microtomography system, to non-destructively visualise and quantitatively characterise complex samples, including advanced composites, tissue engineering constructs, biological tissues, minerals and fossils. The non-destructive characterisation of these samples is critical to advance research. The versatile system offers high spatial resolution (down to 500 nm voxel size) and ....A high-resolution X-ray microtomography system. This project aims to establish a Scanco microCT 50 high resolution X-Ray microtomography system, to non-destructively visualise and quantitatively characterise complex samples, including advanced composites, tissue engineering constructs, biological tissues, minerals and fossils. The non-destructive characterisation of these samples is critical to advance research. The versatile system offers high spatial resolution (down to 500 nm voxel size) and large sample size (up to 100 mm diameter). The project will enable progress in advanced composites, additive bio-manufacturing, physiology of biological tissues and palaeontology which will benefit Australian science. Additionally, through commercialisation and the formation of new companies, the project could potentially result in economic and health benefits to the wider Australian population and economy.Read moreRead less