Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This k ....Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This knowledge will reveal how IPO5 controls formation of sperm by revealing what other proteins it binds to and how this affects cell signaling and responses to the environment.
Benefits: This will provide information about potential interventions to control fertility or to repair abnormal cells.
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Inflammation as an early form of maternal-fetal signalling in pregnancy. The project aims to understand the role of inflammatory signalling in marsupial pregnancy. This project is expected to explain why inflammation, a processes normally confined to injury and infection, is a part of reproduction in live-bearing mammals. Outcomes of this project include robust measures of the capacity for, impact of, and evolution of, inflammatory signalling in marsupial pregnancy. The project will provide new ....Inflammation as an early form of maternal-fetal signalling in pregnancy. The project aims to understand the role of inflammatory signalling in marsupial pregnancy. This project is expected to explain why inflammation, a processes normally confined to injury and infection, is a part of reproduction in live-bearing mammals. Outcomes of this project include robust measures of the capacity for, impact of, and evolution of, inflammatory signalling in marsupial pregnancy. The project will provide new knowledge about the unique biology of Australia's marsupial fauna.This project will provide significant benefits, including enhanced capacity for reproduction research in Australia, new international collaborations between Melbourne and Yale, and a new explanation for the puzzling role of inflammation in pregnancy.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100103
Funder
Australian Research Council
Funding Amount
$459,674.00
Summary
Fortifying animal and plant germ cells against proteotoxic stress. Cellular stress is responsible for widespread inefficiencies in plant and animal reproduction. Using high resolution proteomics and cryo-electron microscopy, this project aims to investigate how plant and animal germ cells respond to environmental stresses that are known to disrupt fertility, and assess two novel strategies to decrease the sensitivity of cells to stress. This project is expected to generate new global knowledge i ....Fortifying animal and plant germ cells against proteotoxic stress. Cellular stress is responsible for widespread inefficiencies in plant and animal reproduction. Using high resolution proteomics and cryo-electron microscopy, this project aims to investigate how plant and animal germ cells respond to environmental stresses that are known to disrupt fertility, and assess two novel strategies to decrease the sensitivity of cells to stress. This project is expected to generate new global knowledge in the area of fertility regulation with the potential to improve the tolerance of crop species to heat stress, prevent economic losses and help to secure future food production. Further, this project has the intended benefit of improving the fertility of animal species that suffer from stress-induced infertility.
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The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less
Linking arterial, brain and cognitive integrity in healthy older adults. This project aims to demonstrate that engaging the brain’s prefrontal cortex, an area that is highly sensitive to ageing, can improve the function of arteries that supply blood to this brain region. Using an innovative optical imaging methodology that maps the brain’s regional arterial health, it aims to generate new knowledge about the link between this arterial system and the progressive decline in cognitive control abili ....Linking arterial, brain and cognitive integrity in healthy older adults. This project aims to demonstrate that engaging the brain’s prefrontal cortex, an area that is highly sensitive to ageing, can improve the function of arteries that supply blood to this brain region. Using an innovative optical imaging methodology that maps the brain’s regional arterial health, it aims to generate new knowledge about the link between this arterial system and the progressive decline in cognitive control ability and in prefrontal cortex structure and function in healthy older adults. This interdisciplinary, international collaboration aims to put Australia at the forefront of brain optical imaging methods that may have significant benefits by informing approaches to promote and maintain healthy brain and cognition in old age.Read moreRead less
Ultra-low fouling active surfaces. This project aims to develop chemistries and fabrication approaches through innovative materials evaluation to develop ultra-low fouling active electrode surfaces. Development of ultra-low fouling surfaces will have significant impact in a range of applications where system or device failure is attributed to fouling. The growing field of bionics, where implantable electronic devices interface directly with the nervous system, is one such device. The expected ou ....Ultra-low fouling active surfaces. This project aims to develop chemistries and fabrication approaches through innovative materials evaluation to develop ultra-low fouling active electrode surfaces. Development of ultra-low fouling surfaces will have significant impact in a range of applications where system or device failure is attributed to fouling. The growing field of bionics, where implantable electronic devices interface directly with the nervous system, is one such device. The expected outcomes will be an understanding of the material requirements that lead to the elimination of protein and cell accumulation at surfaces that degrades the performance and lifetime of these implants. The findings will benefit any application where fouling is a problem.Read moreRead less
Assessment of circadian and light interactions in adolescent sleepiness. This project aims to examine the relative contributions of multiple biological clock and sleep factors that may be linked to cognitive function and sleepiness in adolescents. Over 70 per cent of adolescents in Australia experience insufficient sleep. Cross-sectional studies have shown that insufficient sleep and mistimed sleep lead to reduced cognitive function. The project intends to identify specific sleep and circadian m ....Assessment of circadian and light interactions in adolescent sleepiness. This project aims to examine the relative contributions of multiple biological clock and sleep factors that may be linked to cognitive function and sleepiness in adolescents. Over 70 per cent of adolescents in Australia experience insufficient sleep. Cross-sectional studies have shown that insufficient sleep and mistimed sleep lead to reduced cognitive function. The project intends to identify specific sleep and circadian markers that are linked to academic performance, and generate innovative algorithms that predict these associations. The project will provide new knowledge to drive prevention and early intervention programs that use sleep-wake and light exposure information to improve sleep quality.Read moreRead less
Upholding the right to cultural connection for children in care. A positive sense of cultural identity is critical to wellbeing, yet children in out-of-home care often lose their cultural identities and connections. There is little evidence to guide out-of-home care agencies to support a culturally meaningful foster care placement for non-Indigenous culturally and linguistically diverse children. This project tests promising practices identified by the partner organisations and research literatu ....Upholding the right to cultural connection for children in care. A positive sense of cultural identity is critical to wellbeing, yet children in out-of-home care often lose their cultural identities and connections. There is little evidence to guide out-of-home care agencies to support a culturally meaningful foster care placement for non-Indigenous culturally and linguistically diverse children. This project tests promising practices identified by the partner organisations and research literature to produce an exemplary model of cultural care, with input from children, carers and birth families. Trial implementation in the partner organisations will inform guidelines and recommendations so that the model can inform policy and practice in out-of-home care across Australia.
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ARC Centre of Excellence in Population Ageing Research. This Centre intends to generate crucial knowledge to inform social and economic responses to population ageing, one of the most important issues of the 21st century. Population ageing exerts unprecedented pressures on social norms and policy institutions, both in Australia and around the world. Leading researchers from a range of disciplines will undertake multidisciplinary research to help governments, businesses, and consumers prepare for ....ARC Centre of Excellence in Population Ageing Research. This Centre intends to generate crucial knowledge to inform social and economic responses to population ageing, one of the most important issues of the 21st century. Population ageing exerts unprecedented pressures on social norms and policy institutions, both in Australia and around the world. Leading researchers from a range of disciplines will undertake multidisciplinary research to help governments, businesses, and consumers prepare for and make better decisions for an ageing world, with consequent social and economic benefits for families and communities expected to flow to Australia, the Asian region and the world.Read moreRead less