A sentinel network for vibration-based termite control. Termite damage is costly and eradication via chemicals is hazardous to environment and health. As termites use vibrations to make foraging decisions and eavesdrop on competitors/predators, it is feasible but not attempted hitherto to detect and control termites using vibrations. A smart sentinel network will be developed to enable timber infrastructure to be continuously monitored for termites and for termites to be repelled using specific ....A sentinel network for vibration-based termite control. Termite damage is costly and eradication via chemicals is hazardous to environment and health. As termites use vibrations to make foraging decisions and eavesdrop on competitors/predators, it is feasible but not attempted hitherto to detect and control termites using vibrations. A smart sentinel network will be developed to enable timber infrastructure to be continuously monitored for termites and for termites to be repelled using specific vibration signals and manipulated structures, with minimal environmental and health impacts. For this network to be efficient and effective, an improved understanding on how vibrations influence termite sociality will be obtained by studying habituation and signal adaptation on collective behaviour.Read moreRead less
Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would p ....Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would play an important role in preventing avian influenza outbreaks, which are currently affecting both developed and developing countries, costing millions of dollars due to the death and culling of infected poultry.Read moreRead less
Multiscale modelling and nondeterministic optimisation for reliable stents. This project aims to study modelling and optimisation for a more reliable design of intravascular stents. Intravascular stents are a class of lifelong micro-devices to support blood vessel for restoring circulation. Despite its remarkable initial outcome, the high rate of long-term mechanical failure remains a major concern. This project will tackle plasticity, fatigue damage and fracture across different length scales. ....Multiscale modelling and nondeterministic optimisation for reliable stents. This project aims to study modelling and optimisation for a more reliable design of intravascular stents. Intravascular stents are a class of lifelong micro-devices to support blood vessel for restoring circulation. Despite its remarkable initial outcome, the high rate of long-term mechanical failure remains a major concern. This project will tackle plasticity, fatigue damage and fracture across different length scales. The proposed optimisation is expected to minimise failure, thereby enhancing the longevity and reliability of stent therapy. This will have significant benefits, such as accommodating variations in stents and service conditions for achieving a long-lasting and reliable therapeutical outcome.Read moreRead less
Individually addressable, active, multipoint electrodes for bio-potential recording and electrical impedance imaging. We will develop non-invasive devices based on biosignal and impedance monitoring. They will be highly portable and based on comfortable electrode patches that can be applied quickly in emergencies. The technology may be used to save lives and reduce disabilities by monitoring strokes and heart attacks and stimulate Australia's biomedical industry.
Discovery Early Career Researcher Award - Grant ID: DE120102451
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Spatial control of nanoporous materials for microfabrication. Treatment of numerous medical conditions will be revolutionised by biomedical devices that can deliver or remove selected molecules in precise locations (for example oxygenation of tissues, release of antitumor agents, toxin neutralisation). New lithographic protocols will be developed to enable the use of nanoporous filters directly for such purposes.
Enhanced brain and muscle signal separation verified by electrical scalp recordings from paralysed awake humans. This project will develop algorithms to separate brain signals from muscle signals in electrical recordings from the scalp. Cleaner brain signal measurement enables improvements in understanding how the brain works, the diagnosis and management of neurological diseases, and the development of brain-controlled devices for very disabled people.
Tissue-like, nonlinearly elastic nanobiomaterials for soft tissue regeneration. The purpose of this project is to advance the discipline of soft tissue engineering and regeneration with novel biomaterials, nanotechnology and novel clinical treatment concepts. The key outcomes include new elastic tissue-like nanobiomaterials, new varieties of medical implants and innovative treatment methodology.
Engineering Processable, Tough Hydrogels with Biological Activity. The project aims to design a new class of tough hydrogels to address issues in engineering complex soft and robust structures. These hydrogels have superior properties compared with current materials as they are biologically active, processable by various manufacturing techniques, elastic and have a capacity for rapid self-recovery that are ideal for soft tissues. Their physical property is tunable by modification of their compos ....Engineering Processable, Tough Hydrogels with Biological Activity. The project aims to design a new class of tough hydrogels to address issues in engineering complex soft and robust structures. These hydrogels have superior properties compared with current materials as they are biologically active, processable by various manufacturing techniques, elastic and have a capacity for rapid self-recovery that are ideal for soft tissues. Their physical property is tunable by modification of their compositions that enable construction of complex seamless structure such as valved conduit with anistropic property. Expected outcomes of this project include new insights into material design, multi-physics modelling, and multi-material additive manufacturing for broad applications in soft robotics and medical implants.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100018
Funder
Australian Research Council
Funding Amount
$362,441.00
Summary
Engineering suspended particle sprays through controlled cavitation. This project aims to use cavitation to engineer particle size in sprays of micronised particles suspended in a propellant, and develop a physical mechanism for this process. Understanding how cavitation affects the size of agglomerates in the liquid phase and droplet size in a spray is critical to developing spray devices that require precise control over the final particle size. This will be achieved through high-resolution op ....Engineering suspended particle sprays through controlled cavitation. This project aims to use cavitation to engineer particle size in sprays of micronised particles suspended in a propellant, and develop a physical mechanism for this process. Understanding how cavitation affects the size of agglomerates in the liquid phase and droplet size in a spray is critical to developing spray devices that require precise control over the final particle size. This will be achieved through high-resolution optical imaging techniques and synchrotron X-ray diagnostics. This project is expected to provide physical insight with applications for inhaled and topical pharmaceutical sprays, and industry spray drying of food products.Read moreRead less
Rapid Pathogen Detection using Super-Sensitive Multiplexing Nanophotonic Probes. Responding to an urgent need to advance rapid molecular diagnostics, this project aims to explore new photonics and biochemistry approaches to DNA recognition. It is anchored on proprietary light-emitting nanodots which have single-molecule sensitivity in conjunction with tunable optical identities. The project aims to develop a multiplexing reagent library of DNA probes to sense trace DNA molecules and to recognise ....Rapid Pathogen Detection using Super-Sensitive Multiplexing Nanophotonic Probes. Responding to an urgent need to advance rapid molecular diagnostics, this project aims to explore new photonics and biochemistry approaches to DNA recognition. It is anchored on proprietary light-emitting nanodots which have single-molecule sensitivity in conjunction with tunable optical identities. The project aims to develop a multiplexing reagent library of DNA probes to sense trace DNA molecules and to recognise multiple pathogens in a single assay. This innovation aims to create a hybrid-Polymerase Chain Reaction (PCR) technology platform for current industry-standard pathogen detection tests. The outcomes of the project aim to enable DNA based pathogen diagnostics within 90 minutes, four times faster than the current tests.Read moreRead less