Assessing The Impact Of A Multi-component Intervention To Improve Dietary Intake Of Indigenous Australian Children And Their Families Living In Remote Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,455,043.00
Summary
Sugar-sweetened beverage consumption seems to contribute to obesity and diabetes. We aim to test the impact of multi-component intervention including a school-based nutrition education program combining high levels of parental involvement plus a supportive environment to reduce sugar-sweetened beverage consumption and improve healthy eating among Indigenous Australian children and their families living in remote communities.
Adding An Electronic-cigarette To Standard Behavioural Treatment For Low-socioeconomic Status Smokers: A Randomised Trial.
Funder
National Health and Medical Research Council
Funding Amount
$1,381,127.00
Summary
Behavioural and pharmacological approaches to smoking cessation are effective at helping people to quit but long-term quit rates remain low, especially among low-SES Australians. The electronic cigarette may complement current treatment approaches. We will conduct a large-scale trial to determine if “e-cigarettes” can improve on the efficacy of existing treatments. The findings would have immediate practical implications that could reduce the preventable deaths of many tobacco smokers.
School Versus Community-based Albendazole Deworming For Control Of Soil Transmitted Helminths In School-age Children In The Philippines – A Cluster Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,336,408.00
Summary
Intestinal parasites are a global health problem. The World Health Organization recommends regular distribution of deworming drugs, targeting school aged children. This is effective for the children receiving the drugs but does not have an impact in the wider community. We aim to determine the best strategy for delivery of deworming drugs, to achieve the maximum benefit both for children and wider community, by directly comparing the benefits of a school-targeted vs a community-mass approach.
IMPROVE - Investigating Medication Re-Purposing To Reduce Risk Of OVarian Cancer And Extend Survival
Funder
National Health and Medical Research Council
Funding Amount
$430,196.00
Summary
Ovarian cancer is the 6th most common cause of cancer death in women and the proportion of women who die from their disease has not improved substantially over time. This large-scale study will use de-identified data from the Pharmaceutical Benefits Scheme, the Australian Cancer Database and the National Death Index to investigate whether medications commonly used for other conditions can help decrease the risk of ovarian cancer developing or improve survival from ovarian cancer after diagnosis.
Improving School Transition By Improving Child Sleep: A Translational Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$745,827.00
Summary
A successful transition to school sets a child on a path for life. A poor transition can lead to early drop out, poor peer relationships and poor emotional skills. In 2008/09, we found that a brief sleep intervention for children improved key determinants of a successful transition including social-emotional functioning and parent mental health. We now plan to see if the same intervention, delivered by school nurses, can have a similar effect.
Community Action For Smoking Cessation In Remote Aboriginal Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,162,650.00
Summary
Smoking rates halved in Australia over the past 30 years to below 20% in 2004. However, Indigenous Australians continued to smoke at more than double this rate. In remote Aboriginal communities in the NT's 'Top End', over two-thirds of the population smoke. Smoking tobacco causes the greatest burden of disease for Australians generally. For Indigenous Australians, it is the single most important reversible risk factor for morbidity and premature mortality. With no sign of reduction in smoking le ....Smoking rates halved in Australia over the past 30 years to below 20% in 2004. However, Indigenous Australians continued to smoke at more than double this rate. In remote Aboriginal communities in the NT's 'Top End', over two-thirds of the population smoke. Smoking tobacco causes the greatest burden of disease for Australians generally. For Indigenous Australians, it is the single most important reversible risk factor for morbidity and premature mortality. With no sign of reduction in smoking levels, Indigenous Australians remain at greater risk of hospitalisations or death from many tobacco-related illnesses. Smoking in Australia was reduced through individually-oriented measures, public education and supply control. These strategies have either not been tried or have not been adequately studied in Aboriginal communities. Effective interventions could provide major health gains for Aboriginal Australians and reduce health costs. The intervention we propose will be based on an agreement whereby four remote communities in the 'Top End' will make a pact with the researchers to jointly try to reduce tobacco smoking using community-wide mobilisation, training and education. The intervention with have multiple components. We will not evaluate each component separately. The effect of the whole intervention on smoking will be assessed. Tobacco sales for the whole community in these small isolated localities, a sensitive and reliable measure, should decline if the intervention works. Tobacco smokers will be assessed before the intervention in each community and followed up twice to assess quit rates. Quit rates should go up. Five years are needed for the study because smoking behaviour change does not happen quickly or at peoples' first attempt. With staggered implementation of the intervention, i.e. not starting in all communities at once, reductions in smoking in more than one community will make us confident that the intervention worked.Read moreRead less
New Treatments For Malaria Targeting Both The Sexual And Asexual Stages Of The Causative Parasite, Plasmodium Falciparum
Funder
National Health and Medical Research Council
Funding Amount
$731,155.00
Summary
We have discovered a potent antimalarial compound class. In this research plan we will improve their metabolic stability such that we can progress them as potential oral cures for malaria. We will also elucidate their mechanism of action and this will aid therapeutic development.
A Pharmacological Targeting Approach Implementing Albumin As A Carrier Of A Novel Chemotherapeutic
Funder
National Health and Medical Research Council
Funding Amount
$560,659.00
Summary
New drugs for cancer therapy are essential to develop that overcome resistance to standard chemotherapeutics. We have developed potent anti-cancer chelators that bind to the abundant plasma protein, albumin. Our studies showed increased tumour cell uptake of the chelator, Dp44mT, mediated by albumin. We will elucidate the mechanisms of their albumin-mediated uptake, with the aim to implement albumin nanoparticles as carriers of novel chelators to selectively target tumours.
The Effectiveness Of A Comprehensive ‘universal’ And ‘targeted’ Intervention To Prevent Substance Use And Related Harms In Adolescents: The CAP Project
Funder
National Health and Medical Research Council
Funding Amount
$755,906.00
Summary
Alcohol and other drug use are common amongst Australian adolescents and the disability associated with this use is considerable. Prevention is clearly needed, yet we have few models of well implemented prevention programs that are effective in maximisising prevention outcomes.The current proposal addresses this gap by evaluating a novel approach to preventing substance use and related harms in adolescents by combining effective 'universal' and 'targeted' school-based prevention programs in a su ....Alcohol and other drug use are common amongst Australian adolescents and the disability associated with this use is considerable. Prevention is clearly needed, yet we have few models of well implemented prevention programs that are effective in maximisising prevention outcomes.The current proposal addresses this gap by evaluating a novel approach to preventing substance use and related harms in adolescents by combining effective 'universal' and 'targeted' school-based prevention programs in a sustainable delivery platform.Read moreRead less
Improving Outcomes For People With Depression In Community Settings: A Cluster RCT
Funder
National Health and Medical Research Council
Funding Amount
$803,554.00
Summary
Depression affects 350 million people worldwide. Given the pivotal role of primary care in the management of depression, effective strategies are needed to assist GPs in the delivery of patient-centred depression care. This study will test the effectiveness of providing GPs with education; as well as feedback about patients’ self-reported depressive scores using a standardised instrument and perceived need and preferences for help. This cluster RCT will be the first Australian trial of its kind.