An Integrated General Practice And Pharmacy-based Intervention To Promote The Prescription And Use Of Appropriate Preventive Medications Among Individuals At High Cardiovascular Risk.
Funder
National Health and Medical Research Council
Funding Amount
$2,380,071.00
Summary
We will conduct a randomised controlled trial that combines three methods to reduce risk factors and improve outcomes for people with cardiovascular disease (CVD). The methods include administration of a polypill, a GP-focused point-of-care intervention, and a pharmacy-led intervention to improve commencement and persistence with taking medications. We expect that integrating these three approaches will lead to large reductions in CVD risk factor levels for participants.
IMPROVE - Investigating Medication Re-Purposing To Reduce Risk Of OVarian Cancer And Extend Survival
Funder
National Health and Medical Research Council
Funding Amount
$430,196.00
Summary
Ovarian cancer is the 6th most common cause of cancer death in women and the proportion of women who die from their disease has not improved substantially over time. This large-scale study will use de-identified data from the Pharmaceutical Benefits Scheme, the Australian Cancer Database and the National Death Index to investigate whether medications commonly used for other conditions can help decrease the risk of ovarian cancer developing or improve survival from ovarian cancer after diagnosis.
New Treatments For Malaria Targeting Both The Sexual And Asexual Stages Of The Causative Parasite, Plasmodium Falciparum
Funder
National Health and Medical Research Council
Funding Amount
$731,155.00
Summary
We have discovered a potent antimalarial compound class. In this research plan we will improve their metabolic stability such that we can progress them as potential oral cures for malaria. We will also elucidate their mechanism of action and this will aid therapeutic development.
A Pharmacological Targeting Approach Implementing Albumin As A Carrier Of A Novel Chemotherapeutic
Funder
National Health and Medical Research Council
Funding Amount
$560,659.00
Summary
New drugs for cancer therapy are essential to develop that overcome resistance to standard chemotherapeutics. We have developed potent anti-cancer chelators that bind to the abundant plasma protein, albumin. Our studies showed increased tumour cell uptake of the chelator, Dp44mT, mediated by albumin. We will elucidate the mechanisms of their albumin-mediated uptake, with the aim to implement albumin nanoparticles as carriers of novel chelators to selectively target tumours.
Improving Outcomes For People With Depression In Community Settings: A Cluster RCT
Funder
National Health and Medical Research Council
Funding Amount
$803,554.00
Summary
Depression affects 350 million people worldwide. Given the pivotal role of primary care in the management of depression, effective strategies are needed to assist GPs in the delivery of patient-centred depression care. This study will test the effectiveness of providing GPs with education; as well as feedback about patients’ self-reported depressive scores using a standardised instrument and perceived need and preferences for help. This cluster RCT will be the first Australian trial of its kind.
Pharmacological Targeting Of Integrated Oncogenic And Tumour Suppressive Pathways Using Novel Therapeutics.
Funder
National Health and Medical Research Council
Funding Amount
$510,953.00
Summary
We will investigate NDRG1, a novel molecular target that has been demonstrated to inhibit the progression of numerous cancers. We aim to better understand the underlying function of NDRG1 in pancreatic cancer and how we can potentially target this gene with novel therapeutics being developed in our lab. We hope that this new approach will lead to promising treatments and a better outcome for those suffering from pancreatic cancer.
Determining The Impacts Of Epigenetic Modifying Drugs On Germline Programming And Offspring Health
Funder
National Health and Medical Research Council
Funding Amount
$863,918.00
Summary
New drugs have been developed that inhibit specific enzymes that regulate epigenetic pathways in cells. These pathways significantly affect growth and development in offspring and may represent a risk to future children of patients taking the drug. This project will determine these risks and provide data for developing clinical guidelines for safe use of the drugs.
Dissecting The TMPRSS6 Regulation Of Iron Homeostasis
Funder
National Health and Medical Research Council
Funding Amount
$613,311.00
Summary
Iron overload and anaemia are two of the most significant health problems affecting humans. Understanding how the body regulates iron levels is key to our understanding of these disorders and to the future development of new therapies. This research is aimed at understanding how a hormone produced in the liver called hepcidin that maintains iron balance is regulated. This research may lead to novel therapies aimed at correcting the iron balance in conditions of iron overload or anaemia
Social And Cultural Resilience And Emotional Wellbeing Of Aboriginal Mothers In Prison (SCREAM)
Funder
National Health and Medical Research Council
Funding Amount
$925,847.00
Summary
The increasing imprisonment of Aboriginal women is a major public health issue affecting Aboriginal communities. One way in which the burden of disease and cycle of incarceration within families can be addressed is by improving health outcomes for incarcerated Aboriginal mothers and female carers. This mixed-methods study uses appropriate health measures, narrative data and action research to identify culturally safe models of health care for delivery in prisons and on re-integration to the comm ....The increasing imprisonment of Aboriginal women is a major public health issue affecting Aboriginal communities. One way in which the burden of disease and cycle of incarceration within families can be addressed is by improving health outcomes for incarcerated Aboriginal mothers and female carers. This mixed-methods study uses appropriate health measures, narrative data and action research to identify culturally safe models of health care for delivery in prisons and on re-integration to the community.Read moreRead less
Implementation And Sustainability Of Non-surgical Intervention For Dental Caries In General Dental Practice
Funder
National Health and Medical Research Council
Funding Amount
$390,388.00
Summary
Dentists in NSW and the ACT used new protocols to stop the spread of tooth decay. Many decayed teeth were then remineralised without the use of injections or drilling and filling. The process by which the dentists reorganised their practices to implement the protocols and how they explained them to their patients and practice staff will now be investigated to discover how best to promote their use Australia-wide. The sustainability and cost-effectiveness of this type of care will be measured.