Environmentally Sustainable Solvents for Natural Pharmaceutical Extraction Processes. Australia supplies 25 per cent of the world's pain relieving medicinal opiates which contributes to a $200 million export industry for Australia. The active pharmaceutical ingredients are extracted and purified at GlaxoSmithKline’s (GSK) Port Fairy processing plant using a solvent extraction based process. Together with GSK the project team aim to examine the use of environmentally sustainable bio-derived natur ....Environmentally Sustainable Solvents for Natural Pharmaceutical Extraction Processes. Australia supplies 25 per cent of the world's pain relieving medicinal opiates which contributes to a $200 million export industry for Australia. The active pharmaceutical ingredients are extracted and purified at GlaxoSmithKline’s (GSK) Port Fairy processing plant using a solvent extraction based process. Together with GSK the project team aim to examine the use of environmentally sustainable bio-derived natural solvents to replace the volatile organic compound (VOC) fossil fuels based solvents used in the current process. Due to environmental and health concerns associated with VOCs the development of alternative solvents will be of great benefit to not only GSK but a range of other processing industries that also use VOC based solvent extraction processes.Read moreRead less
The Development of New Carrier Technologies for Spray-Dried Fruit Extracts. This project aims to develop new carrier techniques for spray drying fruit extracts based on the use of natural fibres, with the aim of overcoming a key problem in the operation of spray dryers for producing powders, the deposition of particles on walls. Carriers are non-sticky materials that effectively dilute the stickiness of any materials. The significance is that it will use waste products from fruit processing (th ....The Development of New Carrier Technologies for Spray-Dried Fruit Extracts. This project aims to develop new carrier techniques for spray drying fruit extracts based on the use of natural fibres, with the aim of overcoming a key problem in the operation of spray dryers for producing powders, the deposition of particles on walls. Carriers are non-sticky materials that effectively dilute the stickiness of any materials. The significance is that it will use waste products from fruit processing (the fibres from skins) to overcome this problem, and it will also be possible to dry sticky materials using material from the fruit itself, rather than additives such as maltodextrin.Read moreRead less
Epitaxial Stacking of Nanoporous Nanosheets for Next-generation Membranes. The project aims to develop high-precision selective membranes which are urgently needed in Australian key industries for solute-solute separation by constructing vertically-aligned and chemically-tailorable nanochannels using two-dimensional porous nanosheets as building blocks. The project expects to generate advanced knowledge in the areas of nanosheet synthesis and functionalisation, membrane design and fabrication, s ....Epitaxial Stacking of Nanoporous Nanosheets for Next-generation Membranes. The project aims to develop high-precision selective membranes which are urgently needed in Australian key industries for solute-solute separation by constructing vertically-aligned and chemically-tailorable nanochannels using two-dimensional porous nanosheets as building blocks. The project expects to generate advanced knowledge in the areas of nanosheet synthesis and functionalisation, membrane design and fabrication, selective transport of solutes and applications. The membranes developed in the project should make existing separation processes more effective and sustainable and advance emerging applications in pharmaceutical, dairy and mining industries, providing significant economic and environmental benefits to Australia.Read moreRead less
Powder blending for dry powder inhalers: a new approach for direct control of powder structure. Over 80 per cent of pharmaceutical products involve the processing of powders. This project will generate new knowledge of how to assemble fine and cohesive particles into the structure required for dry powder inhaler products, leading to the development of new low-cost medicines in Australia and the Asia Pacific region.
A skin-on-a-chip device for investigating wound healing. This project aims to research the mechanism of skin wound healing. It will design a skin-on-a-chip microfluidic device that mimics human skin in vitro. This device will reduce the need for animal studies and assess how active compounds heal wounds. This project will design smart polymers with superior properties for controlled delivery of multiple active compounds in this device and choose the most effective combination of compounds to boo ....A skin-on-a-chip device for investigating wound healing. This project aims to research the mechanism of skin wound healing. It will design a skin-on-a-chip microfluidic device that mimics human skin in vitro. This device will reduce the need for animal studies and assess how active compounds heal wounds. This project will design smart polymers with superior properties for controlled delivery of multiple active compounds in this device and choose the most effective combination of compounds to boost skin healing rate. This knowledge may ultimately be used to develop wound dressings that maximise healing rate for various skin defects such as chronic wounds and decrease health care costs.Read moreRead less
Granulation of hydrophobic powders: design and control of granule structure. This unique project will further enhance Australia's established world-class excellence in granulation research, and will assist in setting up a new school of excellence in granulation at Monash University. The innovative use of normally problematic material properties to produce 'designer granules' is a clear example of a 'Frontier Technologies' that can be used to develop 'Advanced Materials' for the next generation o ....Granulation of hydrophobic powders: design and control of granule structure. This unique project will further enhance Australia's established world-class excellence in granulation research, and will assist in setting up a new school of excellence in granulation at Monash University. The innovative use of normally problematic material properties to produce 'designer granules' is a clear example of a 'Frontier Technologies' that can be used to develop 'Advanced Materials' for the next generation of agricultural, food and pharmaceutical industries, particularly for delivery of hydrophobic drugs. The innovative ideas presented in this proposal are expected to provide multiple opportunities for collaboration with national and international research institutions and pharmaceutical companies. Read moreRead less
Novel inkjet-printed organic solvent nanofiltration membranes. The pharmaceutical industry is one of fastest growing industries in Australia. Manufacturing pharmaceutical products requires the use of hazardous and expensive organic solvents, which are toxic for the environment and expensive to recover due to the energy intensive thermal process required. This project aims to discover and manufacture a novel, low-cost, chemically robust nanomaterial-based membrane using an industry scalable inkje ....Novel inkjet-printed organic solvent nanofiltration membranes. The pharmaceutical industry is one of fastest growing industries in Australia. Manufacturing pharmaceutical products requires the use of hazardous and expensive organic solvents, which are toxic for the environment and expensive to recover due to the energy intensive thermal process required. This project aims to discover and manufacture a novel, low-cost, chemically robust nanomaterial-based membrane using an industry scalable inkjet printing process. The membrane will be resistant to organic solvents while efficiently recovering valuable and hazardous organic solvents with minimum environmental footprint. It will effectively provide for the future growth of the Australian pharmaceutical industry while also having global applications.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101687
Funder
Australian Research Council
Funding Amount
$340,000.00
Summary
Nanostructure Tailoring of Inorganic Membranes by Rapid Thermal Processing. This project aims to produce inorganic membranes with desired nanostructures using a Rapid Thermal Processing (RTP) technique for gas separation applications. The key concept of the research is that the RTP will be able to achieve thin-film membrane layer with a finer microstructure and pore size control without heat stress-induced cracking. RTP aims to deliver superior membrane performance with less than 10 per cent of ....Nanostructure Tailoring of Inorganic Membranes by Rapid Thermal Processing. This project aims to produce inorganic membranes with desired nanostructures using a Rapid Thermal Processing (RTP) technique for gas separation applications. The key concept of the research is that the RTP will be able to achieve thin-film membrane layer with a finer microstructure and pore size control without heat stress-induced cracking. RTP aims to deliver superior membrane performance with less than 10 per cent of the fabrication time compared to normal slow calcination. The outcomes of this new technology aims to make inorganic membranes a commercial reality and maximize the membrane manufacturing capability and productivity of petrochemcial, chemical and clean coal/energy industries.Read moreRead less
Optimising nanofiltration and reverse osmosis filtration processes for water recycling: effects of fouling and chemical cleaning on trace contaminant removal. In Australia, water recycling is considered a principal measure to manage the current ongoing water shortage and to better protect the environment. Membrane filtration processes play important roles in the treatment of reclaimed municipal wastewater. However, there is very limited knowledge regarding the reliability of such processes in re ....Optimising nanofiltration and reverse osmosis filtration processes for water recycling: effects of fouling and chemical cleaning on trace contaminant removal. In Australia, water recycling is considered a principal measure to manage the current ongoing water shortage and to better protect the environment. Membrane filtration processes play important roles in the treatment of reclaimed municipal wastewater. However, there is very limited knowledge regarding the reliability of such processes in removing trace contaminants from recycled water, which may result in unintended health consequences. This research will lead to a comprehensive understanding of the removal process of such contaminants by membrane filtration. Consequently, the likely avenue of risk can be eliminated and the treatment process can be optimised to achieve economic savings and environmental protection.Read moreRead less
Development of smart material for the adsorption of oil spills on roads. The cost of road fuel spills in both Australia and worldwide is enormous. The research objective is to develop an admixture suitable for the absorption/adsorption of fuel and oil from road spills. The material will be designed to be contained within a fabric. The innovation is the application of the admixture in the form of a carpet, which is designed as easily used, non-toxic, recyclable and environmentally friendly. T ....Development of smart material for the adsorption of oil spills on roads. The cost of road fuel spills in both Australia and worldwide is enormous. The research objective is to develop an admixture suitable for the absorption/adsorption of fuel and oil from road spills. The material will be designed to be contained within a fabric. The innovation is the application of the admixture in the form of a carpet, which is designed as easily used, non-toxic, recyclable and environmentally friendly. The application is rapid. The successful development of the material has enormous economic benefits to Australia, providing a new industry with many employees. This new industry has the potential to bring great wealth to Australia.Read moreRead less