Powder blending for dry powder inhalers: a new approach for direct control of powder structure. Over 80 per cent of pharmaceutical products involve the processing of powders. This project will generate new knowledge of how to assemble fine and cohesive particles into the structure required for dry powder inhaler products, leading to the development of new low-cost medicines in Australia and the Asia Pacific region.
Granulation of hydrophobic powders: design and control of granule structure. This unique project will further enhance Australia's established world-class excellence in granulation research, and will assist in setting up a new school of excellence in granulation at Monash University. The innovative use of normally problematic material properties to produce 'designer granules' is a clear example of a 'Frontier Technologies' that can be used to develop 'Advanced Materials' for the next generation o ....Granulation of hydrophobic powders: design and control of granule structure. This unique project will further enhance Australia's established world-class excellence in granulation research, and will assist in setting up a new school of excellence in granulation at Monash University. The innovative use of normally problematic material properties to produce 'designer granules' is a clear example of a 'Frontier Technologies' that can be used to develop 'Advanced Materials' for the next generation of agricultural, food and pharmaceutical industries, particularly for delivery of hydrophobic drugs. The innovative ideas presented in this proposal are expected to provide multiple opportunities for collaboration with national and international research institutions and pharmaceutical companies. Read moreRead less
Unravelling the mechanics of particle deposition at the micro-scale. This project aims to discover the mechanisms responsible for the interactions between aerosol particles and surfaces in a range of air flow conditions. The project expects to transform our understanding of particle deposition through a combination of novel laser-based diagnostic techniques, optical coherence tomography, and state of the art particle formulation methodologies. Expected outcomes of the project include delivery of ....Unravelling the mechanics of particle deposition at the micro-scale. This project aims to discover the mechanisms responsible for the interactions between aerosol particles and surfaces in a range of air flow conditions. The project expects to transform our understanding of particle deposition through a combination of novel laser-based diagnostic techniques, optical coherence tomography, and state of the art particle formulation methodologies. Expected outcomes of the project include delivery of new methods to optimise particle deposition, development of tunable powder formulations, as well as definition of particle-surface interaction mechanisms in flows. The project should provide significant benefits to particle systems for applications ranging from additive manufacturing to aerosol delivery.Read moreRead less
Jet breakup of emulsions for the production of designer microparticulate drug delivery systems. Drug delivery systems are an important and growing part of the pharmaceutical and biotechnology market. The growth is estimated to be at 23% p.a. and is tied to the requirements for more precise and complex delivery profiles by highly potent drugs or vaccines (bioactives). To achieve the required level of control and precision, improved encapsulation technologies are needed to produce particles of a p ....Jet breakup of emulsions for the production of designer microparticulate drug delivery systems. Drug delivery systems are an important and growing part of the pharmaceutical and biotechnology market. The growth is estimated to be at 23% p.a. and is tied to the requirements for more precise and complex delivery profiles by highly potent drugs or vaccines (bioactives). To achieve the required level of control and precision, improved encapsulation technologies are needed to produce particles of a precise size and narrow size distribution. This project aims to develop an innovative technology for the production of superior uniformly sized particulate drug delivery systems for the delivery of the "next generation" bioactives.Read moreRead less
Developing novel aerosol inhalers for pulmonary drug delivery from the fundamental understanding of powder dispersion mechanisms. The project seeks to understand how powder aerosol inhalers can be significantly improved. The outcome will provide therapeutic benefits to the Australian community for better treatment of respiratory diseases and facilitate environmentally friendly technology since these inhalers do not require any harmful organic solvents to operate.
Environmentally Sustainable Solvents for Natural Pharmaceutical Extraction Processes. Australia supplies 25 per cent of the world's pain relieving medicinal opiates which contributes to a $200 million export industry for Australia. The active pharmaceutical ingredients are extracted and purified at GlaxoSmithKline’s (GSK) Port Fairy processing plant using a solvent extraction based process. Together with GSK the project team aim to examine the use of environmentally sustainable bio-derived natur ....Environmentally Sustainable Solvents for Natural Pharmaceutical Extraction Processes. Australia supplies 25 per cent of the world's pain relieving medicinal opiates which contributes to a $200 million export industry for Australia. The active pharmaceutical ingredients are extracted and purified at GlaxoSmithKline’s (GSK) Port Fairy processing plant using a solvent extraction based process. Together with GSK the project team aim to examine the use of environmentally sustainable bio-derived natural solvents to replace the volatile organic compound (VOC) fossil fuels based solvents used in the current process. Due to environmental and health concerns associated with VOCs the development of alternative solvents will be of great benefit to not only GSK but a range of other processing industries that also use VOC based solvent extraction processes.Read moreRead less
Multi-drug dry powder inhalation systems for the effective treatment of chronic obstructive pulmonary disease. Utilising a combination of particle engineering, computer modeling, rapid prototyping and high-speed 3D imaging this project will develop a novel approach to treat chronic obstructive pulmonary disease. A multi-drug particle system whose surface is independent of the drugs incorporated will be optimised in a novel high efficiency inhalation device.
The Development of New Carrier Technologies for Spray-Dried Fruit Extracts. This project aims to develop new carrier techniques for spray drying fruit extracts based on the use of natural fibres, with the aim of overcoming a key problem in the operation of spray dryers for producing powders, the deposition of particles on walls. Carriers are non-sticky materials that effectively dilute the stickiness of any materials. The significance is that it will use waste products from fruit processing (th ....The Development of New Carrier Technologies for Spray-Dried Fruit Extracts. This project aims to develop new carrier techniques for spray drying fruit extracts based on the use of natural fibres, with the aim of overcoming a key problem in the operation of spray dryers for producing powders, the deposition of particles on walls. Carriers are non-sticky materials that effectively dilute the stickiness of any materials. The significance is that it will use waste products from fruit processing (the fibres from skins) to overcome this problem, and it will also be possible to dry sticky materials using material from the fruit itself, rather than additives such as maltodextrin.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0238094
Funder
Australian Research Council
Funding Amount
$197,000.00
Summary
Fine and Ultrafine Particle - Characterisation and Research Facility. The proposed grant aims to establish an integrated facility for characterising and researching fine and ultrafine particles. It will serve various research groups of three collaborating universities. Current facilities are limited to characterisation of liquid-borne particles down to 10 nm size. To extend the groups research interests into aerosols and nanoparticles the facilities requested in this grant are essential. Equipme ....Fine and Ultrafine Particle - Characterisation and Research Facility. The proposed grant aims to establish an integrated facility for characterising and researching fine and ultrafine particles. It will serve various research groups of three collaborating universities. Current facilities are limited to characterisation of liquid-borne particles down to 10 nm size. To extend the groups research interests into aerosols and nanoparticles the facilities requested in this grant are essential. Equipment critical for research into catalytic processes is also requested. Integration of the groups will create a force that institutions and industries,nation-wide, can turn to when the need for competent analytical and research solutions for particles and catalysis arises.Read moreRead less
Engineering the next generation of scaffolds. Engineering the next generation of scaffolds. This project aims to develop high efficiency quantum dots based on carbon nanomaterials, integrated with scaffolds and viable tissue cells, which can be used to develop smart implants with monitoring capabilities to reduce patient trauma and expenses. In certain cases, more than 50% of medical implants fail. Improving effective intervention is urgently needed, particularly monitoring of implants and early ....Engineering the next generation of scaffolds. Engineering the next generation of scaffolds. This project aims to develop high efficiency quantum dots based on carbon nanomaterials, integrated with scaffolds and viable tissue cells, which can be used to develop smart implants with monitoring capabilities to reduce patient trauma and expenses. In certain cases, more than 50% of medical implants fail. Improving effective intervention is urgently needed, particularly monitoring of implants and early diagnosis to prevent rejections and adverse reactions. Current methods are inefficient, expensive, and induce toxicity. A non-toxic and non-invasive method to monitor the progress of tissue regeneration and wound healing is expected to place Australia at the forefront of developing implants.Read moreRead less