Mechanism Of Anoxic Iron Acquisition In Pathogenic Bacteria
Funder
National Health and Medical Research Council
Funding Amount
$536,280.00
Summary
All organisms require iron for their survival, including all bacterial species. Bacterial pathogens growing in anaerobic environments, such as in our gut, gum, or tissue, sequester iron through the divalent iron transporter FeoB. We aim to divulge the mechanism of iron transport through FeoB by structural and functional studies, and thus provide a scaffold for a non-conventional antimicrobial target.
Characterising The Beta-catenin Nuclear Targeting Pathway In Cancer
Funder
National Health and Medical Research Council
Funding Amount
$485,081.00
Summary
Bowel cancer is caused by inherited gene mutations that cause build-up of beta-catenin protein in the cell nucleus. Bowel cancer is the second largest cause of cancer deaths in Australia. We aim to study the mechanisms controlling beta-catenin accumulation in the nucleus. We will characterise new signalling pathways that control movement and activity of beta-catenin in the nucleus. This will yield insights into the role of beta-catenin in cancer and possible targets for therapy.
Structural And Functional Studies On RNA Nuclear Retention Mediated By Paraspeckles: A Novel Gene Regulation
Funder
National Health and Medical Research Council
Funding Amount
$290,978.00
Summary
Dynamic interactions between proteins and nucleic acids are essential process in gene regulation, where aberrant regulation leads to various diseases including cancers. The project aims to examine the interactions between paraspeckle proteins and nucleic acid molecules via determination of the structures of protein-nucleic acid complexes at the atomic level. The results will provide a better understanding of a recently discovered gene regulation mechanism and a basis for new gene therapy.
A Study To Investigate Alternative Regimens For Pneumococcal Vaccination Of Infants In A Developing Country
Funder
National Health and Medical Research Council
Funding Amount
$1,622,210.00
Summary
Streptococcus pneumoniae (Pnc) is the leading vaccine preventable cause of serious infection in infants. The current Pnc conjugate vaccine is very expensive (approximately USD $200-infant) so it is unlikely to be affordable for most developing countries. Moreover, as health care access in developing countries may be episodic and unreliable, many children do not receive either complete or timely vaccine courses. Therefore, it is important to investigate affordable and flexible ways to deliver thi ....Streptococcus pneumoniae (Pnc) is the leading vaccine preventable cause of serious infection in infants. The current Pnc conjugate vaccine is very expensive (approximately USD $200-infant) so it is unlikely to be affordable for most developing countries. Moreover, as health care access in developing countries may be episodic and unreliable, many children do not receive either complete or timely vaccine courses. Therefore, it is important to investigate affordable and flexible ways to deliver this vaccine, which are safe and effective. A recent WHO-GAVI meeting to address impediments to the introduction of these vaccines in developing countries recognized the need to evaluate other regimens of Pnc conjugate vaccine as an important research priority. This study has been deliberately formulated with that need in mind. The site for this research is Fiji. Although health services are good, Pnc disease, particularly pneumonia, remains the commonest cause of childhood morbidity and mortality. Fiji has good vaccine coverage and was the first Pacific country to introduce Hib vaccine. The arrival of the new, expensive Pnc conjugate vaccine presents a dilemma for Fiji and many similar countries. The expense of this vaccine would consume a large portion of the health budget. This study has two components: 1. A Phase 2 immunogenicity study (involving 750 infants) to evaluate regimens using reduced numbers of doses of Pnc conjugate vaccine, and using timing of dosing and combinations with the Pnc polysaccharide (PS) vaccine that may be more suited to the epidemiology of Pnc disease in developing countries. 2. An epidemiological study will measure the burden of invasive Pnc disease and pneumonia in Fiji. This will be part of a global effort to address these issues, and will be used to develop rapid assessment tools for these diseases in developing countries. We will seek cofounding for this component.Read moreRead less
Optimising Radiation Therapy Delivery For Cancer Patients Using Daily Image Guidance To Maximize Cure And Reduce Normal Tissue Side Effects
Funder
National Health and Medical Research Council
Funding Amount
$510,968.00
Summary
When using radiotherapy to kill tumours, the radiation beams need to be targeted at the tumour, plus a margin of error around it to ensure that it receives sufficient dose despite uncertainties in its exact location relative to reference points used for beam alignment. Advanced statistical modelling techniques applied to data collected from patients will be used to determine the optimal margin width for individual patients to maximise cancer cure while minimising normal tissue side effects.
Neutral hydrogen and galaxy assembly in the distant Universe. This research will produce a snapshot of hydrogen gas in the Universe 6-7 billion years ago. These results, together with galaxy formation models, will tell us how galaxies are assembled to make the beautiful spirals we see today. This project is only possible because of rapid advances in programmable chip technology, part of the massive increase in the speed and complexity of integrated circuit devices.
Our Galaxy: the last hundred million years. Star formation and evolution are the fundamental processes which energize a galaxy and recycle the interstellar medium. In our Galaxy, we have the opportunity to study these processes in great detail. This project uses sensitive radio continuum images from the Molonglo Observatory Synthesis Telescope to discover how this energizing and enrichment occurs. We will use innovative machine learning techniques to identify a potentially new population of Gala ....Our Galaxy: the last hundred million years. Star formation and evolution are the fundamental processes which energize a galaxy and recycle the interstellar medium. In our Galaxy, we have the opportunity to study these processes in great detail. This project uses sensitive radio continuum images from the Molonglo Observatory Synthesis Telescope to discover how this energizing and enrichment occurs. We will use innovative machine learning techniques to identify a potentially new population of Galactic sources and to patrol a new domain in source variability.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0238884
Funder
Australian Research Council
Funding Amount
$220,000.00
Summary
Development of the CANGAROO III Very High Energy Gamma-ray telescope. This international project will explore the only part of the electromagnetic spectrum yet to be subjected to detailed astronomical study. CANGAROO III will span the energy range from ~100GeV to >10TeV, expanding upwards the range of satellite observations, and downwards the range accessible from previous ground-based systems. Gamma-ray observations have opened a new window on the universe and it is clear that there is much to ....Development of the CANGAROO III Very High Energy Gamma-ray telescope. This international project will explore the only part of the electromagnetic spectrum yet to be subjected to detailed astronomical study. CANGAROO III will span the energy range from ~100GeV to >10TeV, expanding upwards the range of satellite observations, and downwards the range accessible from previous ground-based systems. Gamma-ray observations have opened a new window on the universe and it is clear that there is much to be discovered with this new instrument. This project will provide an Australian infrastructure contribution to support the multi-million dollar contribution of our Japanese partners, and thus provide Australian access to a key astrophysical field at very modest cost.Read moreRead less
Low Cost High Precision Radiotherapy: A Synergistic Framework For Tumour Tracking During Treatment
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Advances in technology have enabled radiotherapy to become more sophisticated and more efficient at treating cancer. Yet, despite its sophistication, today radiotherapy suffers from a major problem: whilst we routinely image patients prior to treatment, no anatomical information is available during treatment. This project aims to solve this problem by making use of a number of sensors that are already available in a radiotherapy to track the tumours positions during treatment, when it counts.