Polymer nanoobjects functionalized by polymer brushes: preparation, organization and integration in devices. The proposed project targets the collaboration between two leading research teams. The University of Marburg is leading in the area of the preparation of nanoobjects, while the research team at CAMD (UNSW) focuses on the preparation of well-controlled polymer structures via RAFT polymerisation. The combined strength of both groups seeks to improve the properties of nanodevices by the atta ....Polymer nanoobjects functionalized by polymer brushes: preparation, organization and integration in devices. The proposed project targets the collaboration between two leading research teams. The University of Marburg is leading in the area of the preparation of nanoobjects, while the research team at CAMD (UNSW) focuses on the preparation of well-controlled polymer structures via RAFT polymerisation. The combined strength of both groups seeks to improve the properties of nanodevices by the attachment of well-defined polymer layers. We expect therefore an optimum scientific output with both groups focusing on their research potency next to being able to access new knowledge. The visit to the German research group enables the Australian researchers access to a leading team in nanotechnology.Read moreRead less
Living Free Radical Polymerization for Nano Technology Applications. The proposed linkage project centres on a series of core projects from both the Australian and German collaborators. These core projects range from the synthesis of multifunctional nano- and micro-sphere particles, block copolymer systems used as efficient vehicles for drug delivery purposes to polymer brushes for nano-wires. The collaborating teams will carry out joint research tasks in the above mentioned fields via the excha ....Living Free Radical Polymerization for Nano Technology Applications. The proposed linkage project centres on a series of core projects from both the Australian and German collaborators. These core projects range from the synthesis of multifunctional nano- and micro-sphere particles, block copolymer systems used as efficient vehicles for drug delivery purposes to polymer brushes for nano-wires. The collaborating teams will carry out joint research tasks in the above mentioned fields via the exchange of the CIs and PhD students. The project is planned for a duration of three years to ensure an in-depth approach to the proposed projects.Read moreRead less
Biodegradable polymeric microparticles for targeted delivery. The use of microparticles with tuneable physicochemical properties and loading characteristics is of interest in the fields of biomaterials, drug delivery and imaging. Such engineered particles are likely to address problems associated with conventional drugs and drug carriers, including poor disease site selectivity, polymer toxicity, non-biodegradability and free diffusion of drugs throughout the body. These microparticles may provi ....Biodegradable polymeric microparticles for targeted delivery. The use of microparticles with tuneable physicochemical properties and loading characteristics is of interest in the fields of biomaterials, drug delivery and imaging. Such engineered particles are likely to address problems associated with conventional drugs and drug carriers, including poor disease site selectivity, polymer toxicity, non-biodegradability and free diffusion of drugs throughout the body. These microparticles may provide direct advantages to society, including minimally invasive and fast in-vivo diagnostics, localised delivery of drugs and therapeutic agents with increased bioavailability, patient acceptability and reduced healthcare costs.Read moreRead less
Polyaniline Nanofibre Systems. Advanced materials such as the conducting polymer and applications of these materials at the nanoscale and up is clearly a cutting edge area of international interest. Development of readily processable nano systems has been a challenge with a clear scientific and commercial benefit. This proposal will bring linkages to Australia with the world leader in the field, Professor Kaner -UCLA, on the synthesis of polyaniline nanofibres and associated photowelding process ....Polyaniline Nanofibre Systems. Advanced materials such as the conducting polymer and applications of these materials at the nanoscale and up is clearly a cutting edge area of international interest. Development of readily processable nano systems has been a challenge with a clear scientific and commercial benefit. This proposal will bring linkages to Australia with the world leader in the field, Professor Kaner -UCLA, on the synthesis of polyaniline nanofibres and associated photowelding processes. The opportunities to Australia and the USA will be to expand the potential utility of such systems, which without such interactions would permit others to take a stake hold in this emergent and potentially lucrative technology.Read moreRead less
Development of Novel Detergents for Green Solvent Systems and Their Self-Assembly into Nanostructures. Successful outcomes from this collaborative project will lead to the development of new commercially viable green solvent systems for the chemical industry, e.g. dry cleaning. This has the potential to impact the community on the economic and environmental level, by significantly reducing the costs of current green solvent systems, resulting in greater likelihood of conventional toxic solvent ....Development of Novel Detergents for Green Solvent Systems and Their Self-Assembly into Nanostructures. Successful outcomes from this collaborative project will lead to the development of new commercially viable green solvent systems for the chemical industry, e.g. dry cleaning. This has the potential to impact the community on the economic and environmental level, by significantly reducing the costs of current green solvent systems, resulting in greater likelihood of conventional toxic solvents being replaced. The project will also expand the training of junior and early career scientists by allowing them to work in overseas laboratories.Read moreRead less
Advanced nanoparticle stabilisation and functionalisation: small particles with huge potential. Australia is strongly investing in nanotechnology and through the governments priority goals 'Frontier Technologies for Building and Transforming Australian Industries' it has been recognised as an important area for investment. This proposal will help develop an internationally recognised nano-industry. It is envisaged that the particles made during this work will have direct implications for the pub ....Advanced nanoparticle stabilisation and functionalisation: small particles with huge potential. Australia is strongly investing in nanotechnology and through the governments priority goals 'Frontier Technologies for Building and Transforming Australian Industries' it has been recognised as an important area for investment. This proposal will help develop an internationally recognised nano-industry. It is envisaged that the particles made during this work will have direct implications for the public - creating a new class of medical diagnostic particles with better resolution and specificity. These particles have the potential to diagnose patients more precisely and at an earlier stage than is currently available. Additionally, these particles could be designed to load drugs and hence could be used to treat diseases such as cancer.Read moreRead less
Reversible Addition Fragmentation Chain Transfer (RAFT) Free Radical Copolymerizations of Various Monomers. The proposed project will investigate the structure and properties of statistical copolymers prepared via living free radical polymerization. We will study the characteristics of a wide variety of Reversible Addition Fragmentation Chain Transfer (RAFT) copolymerizations using a range of monomers, including those interesting for biomedical and material science applications. We expect to gai ....Reversible Addition Fragmentation Chain Transfer (RAFT) Free Radical Copolymerizations of Various Monomers. The proposed project will investigate the structure and properties of statistical copolymers prepared via living free radical polymerization. We will study the characteristics of a wide variety of Reversible Addition Fragmentation Chain Transfer (RAFT) copolymerizations using a range of monomers, including those interesting for biomedical and material science applications. We expect to gain a deeper understanding of the influence of the RAFT process on the kinetics and mechanism of copolymerization and the properties of the resulting polymers in order to tailor specific polymer materials for biomedial applications.Read moreRead less
Synthesis and Characterization of Novel Hybrid star polymers grown from carbohydrate clusters. The aim of the project is to make complex polymer architectures based on stars grown from sugar clusters. The star molecules are expected to have unique properties for transporting guest molecules in drug delivery systems. The outcome will be the development of totally biodegradable, non-toxic cluster/star structures capable of complexing to drugs. This is the first attempt to utilise these clusters ....Synthesis and Characterization of Novel Hybrid star polymers grown from carbohydrate clusters. The aim of the project is to make complex polymer architectures based on stars grown from sugar clusters. The star molecules are expected to have unique properties for transporting guest molecules in drug delivery systems. The outcome will be the development of totally biodegradable, non-toxic cluster/star structures capable of complexing to drugs. This is the first attempt to utilise these clusters, with sugar-based vinyl monomers for star synthesis.Read moreRead less
Conformationally constrained and immobilized beta-peptides. The research builds on world-class expertise in Australia (particularly Adelaide) in proteomics to provide a basis for fundamental advances in chemistry that will underpin the development of new pharmaceuticals and smart materials, and future technologies and industries. We create a mix of research at the interface of disciplines within academia and industry, with linkages to the very best international researchers and centres. A new cr ....Conformationally constrained and immobilized beta-peptides. The research builds on world-class expertise in Australia (particularly Adelaide) in proteomics to provide a basis for fundamental advances in chemistry that will underpin the development of new pharmaceuticals and smart materials, and future technologies and industries. We create a mix of research at the interface of disciplines within academia and industry, with linkages to the very best international researchers and centres. A new critical mass of expertise in a number of advancing areas of chemistry, biology, and materials science will be introduced to Australia. This will enhance existing strengths and opportunities in proteomics and biomedical research for the treatment of disease.Read moreRead less
IMPROVED PROPERTIES BY CONTROL OF NANOMETRE AND MOLECULAR STRUCTURE OF CROSSLINKED POLYMERS. This French - Australian collaboration seeks to develop new composite, nanostructured thermosetting materials by control of molecular architecture and phase morphology, and by the incorporation of a range of nanoparticles into crosslinking systems. Such composites are increasingly required in high value industries such as electronics, aerospace and automotive. The project seeks to extend and develop the ....IMPROVED PROPERTIES BY CONTROL OF NANOMETRE AND MOLECULAR STRUCTURE OF CROSSLINKED POLYMERS. This French - Australian collaboration seeks to develop new composite, nanostructured thermosetting materials by control of molecular architecture and phase morphology, and by the incorporation of a range of nanoparticles into crosslinking systems. Such composites are increasingly required in high value industries such as electronics, aerospace and automotive. The project seeks to extend and develop the current successful and productive interaction between the researchers. As well as producing nanomaterials, the participants have extensive, complementary expertise in characterization at the molecular and nanoscale - crucial if the behaviour of these new materials is to be understood, controlled and further new materials rationally designed.Read moreRead less