Engaging ethnic minority and majority blood donors in donor recruitment. Word-of-mouth is a potentially powerful way to recruit blood donors. Talking about donation increases awareness, trust, commitment and positive feelings about donating, particularly in ethnic minority groups. However, donors seldom tell others about donating. This project aims to determine how to motivate blood donors to recruit new donors using word-of-mouth, through research comprising co-design, surveys, and experiments. ....Engaging ethnic minority and majority blood donors in donor recruitment. Word-of-mouth is a potentially powerful way to recruit blood donors. Talking about donation increases awareness, trust, commitment and positive feelings about donating, particularly in ethnic minority groups. However, donors seldom tell others about donating. This project aims to determine how to motivate blood donors to recruit new donors using word-of-mouth, through research comprising co-design, surveys, and experiments. This project will generate new knowledge of how to encourage effective word-of-mouth for pro-social behaviours. Expected outcomes include producing culturally relevant, validated resources that will significantly benefit Australia by encouraging effective conversations to promote blood donation in all communities.Read moreRead less
Economic impacts of disease on older workers: Costs to government and individuals and opportunities for intervention. With an ageing workforce, Australia is at risk of having an inadequate workforce to ensure economic growth and to maintain sufficient taxation revenue to support future needs.
This project will provide fill substantial gaps in the Australian evidence the health conditions that keep older workers out of the labour market and that diminish their own immediate and long-term livi ....Economic impacts of disease on older workers: Costs to government and individuals and opportunities for intervention. With an ageing workforce, Australia is at risk of having an inadequate workforce to ensure economic growth and to maintain sufficient taxation revenue to support future needs.
This project will provide fill substantial gaps in the Australian evidence the health conditions that keep older workers out of the labour market and that diminish their own immediate and long-term livings standards and reduce funds available to government. We will address one of the most significant issues resulting fundamental changes to the demography of the Australian labour market and one is regularly raised by the Prime Minister and Treasurer in their speeches following the Intergenerational Report.Read moreRead less
A NOVEL MOUSE MODEL TO INVESTIGATE THE MECHANISMS OF VIRUS-INDUCED ARTHRITIS
Funder
National Health and Medical Research Council
Funding Amount
$336,000.00
Summary
We have developed a novel animal model by which to study arthritic disease caused by insect-transmitted viruses known as arboviruses. The existence of this model and novel reagents provides an excellent opportunity to further explore the basic mechanisms of infectious disease in a complete functioning animal, rather than specific cultured cells. The study will use modern approaches in molecular and cellular biology to achieve this goal. The production by our immune systems of soluble mediators ( ....We have developed a novel animal model by which to study arthritic disease caused by insect-transmitted viruses known as arboviruses. The existence of this model and novel reagents provides an excellent opportunity to further explore the basic mechanisms of infectious disease in a complete functioning animal, rather than specific cultured cells. The study will use modern approaches in molecular and cellular biology to achieve this goal. The production by our immune systems of soluble mediators (cytokines-chemokines) and antibodies is an overwhelming positive aspect of our physiological response to infection by microbes. Protection from disease by these immune compounds can happen naturally, or the body's ability to produce these factors can be exploited to our benefit via the administration of vaccines. However, these factors can also be detrimental to the host contributing to severe disease. For instance, work performed almost 40 years ago showed for the first time that under particular conditions, antibodies against viruses can enhance infection, instead of inhibiting infection as normally seen. In the intervening years work by scientists all over the world has associated antibody-dependent enhancement (ADE) of infection to many types of viruses; ADE is even thought to be a risk factor to serious disease with dengue virus, and has been shown in vitro for the AIDS virus and Ebola virus. We have recently discovered a molecular mechanism which explains how antibody enhances viral infection in vitro. In studies on immune cells infected with Ross River Virus (RRV) we found that infection helped by antibody resulted in the specific disruption to the production of cellular chemicals which are toxic to viruses. Are these mechanisms of antibody-enhanced infection also found in animals? Will such mode of infection cause enhanced disease and tissue pathology (arthritis) in animals?Read moreRead less
Social Impact and Connection Outcomes Associated with Community Sport. Outcomes of social connection from community sport are widely touted and supported to exist. However, we know little about how social infrastructure actually delivers these benefits. It is difficult to understand and develop practices that organisations can use to maximise the outcomes of sport participation. This research aims to investigate how social infrastructure delivers social connection outcomes associated with commun ....Social Impact and Connection Outcomes Associated with Community Sport. Outcomes of social connection from community sport are widely touted and supported to exist. However, we know little about how social infrastructure actually delivers these benefits. It is difficult to understand and develop practices that organisations can use to maximise the outcomes of sport participation. This research aims to investigate how social infrastructure delivers social connection outcomes associated with community sport. Expected outcomes include novel practice based tools and guidance for community groups to enhance social connection outcomes and new understanding about the role of social infrastructure in enhancing community connection. Improved social connection is expected to improve resilience and community wellbeing.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560758
Funder
Australian Research Council
Funding Amount
$187,000.00
Summary
Dynamics at Interfaces: a facility for the characterisation of the dynamics of structural reorganisation and adsorption at interfaces. Controlling the flow, stability, and general performance of finely dispersed materials is important in a great number of industries from cosmetics to minerals purification. These properties are often controlled by the addition of material that forms a film at the interface between the dispersed material and the solvent. We seek to develop a facility that will ena ....Dynamics at Interfaces: a facility for the characterisation of the dynamics of structural reorganisation and adsorption at interfaces. Controlling the flow, stability, and general performance of finely dispersed materials is important in a great number of industries from cosmetics to minerals purification. These properties are often controlled by the addition of material that forms a film at the interface between the dispersed material and the solvent. We seek to develop a facility that will enable the properties of this film to be characterized, in particular the rate at which the film responds to mechanical and chemical changes. With this knowledge we hope to relate the nanoscopic properties of the adsorbed film to macroscopic properties of the dispersion and be able to tune the structure of the surface film, in order to control the bulk properties of complex fluids.Read moreRead less
Belonging and sexual citizenship among gender and sexual minority youth. In the context of well-documented threats to the mental health and well-being of minority young people, this project will examine the experiences of two different generations of gender and sexual minority youth growing up in Australia, and the sources of support they have found most useful. Innovative contextual analysis will involve documentary and archival research alongside individual and group interviews. Through a focu ....Belonging and sexual citizenship among gender and sexual minority youth. In the context of well-documented threats to the mental health and well-being of minority young people, this project will examine the experiences of two different generations of gender and sexual minority youth growing up in Australia, and the sources of support they have found most useful. Innovative contextual analysis will involve documentary and archival research alongside individual and group interviews. Through a focus on the promotion of well-being and participatory citizenship in a rapidly changing social world, the findings aim to contribute new theory concerning transitions from youth to adulthood, improved methodology for the study of marginal and sometimes hard-to-reach populations, and better quality policy and practice.Read moreRead less
Molecules as probes of the interstellar medium. It is one of the greatest challenges in Nature is to remotely identify what is in space. Interstellar molecules are identified by their spectra, but many features in these spectra are unknown, implying that there are many more molecules in space than we know about. With a stronger understanding of space chemistry, we could predict what should be there and verify it in the lab. Conversely, identification of these features will provide the tools to u ....Molecules as probes of the interstellar medium. It is one of the greatest challenges in Nature is to remotely identify what is in space. Interstellar molecules are identified by their spectra, but many features in these spectra are unknown, implying that there are many more molecules in space than we know about. With a stronger understanding of space chemistry, we could predict what should be there and verify it in the lab. Conversely, identification of these features will provide the tools to understand interstellar chemistry. In this project we combine skills in spectroscopy and astronomy to make these molecules in the laboratory, measure their spectra and thereby identify unknown molecules in space.Read moreRead less
Realistic models of permeation in ion channels. Ion channels are formed by proteins in cell membranes and provide pathways for fast and controlled flow of selected ions. This activity generates action potentials in nerves and muscles that forms the basis of all movement, sensation and thought processes. Recent determination of the crystal structure of channel proteins has enabled construction of models that can relate channel function to its structure--necessary for understanding their operati ....Realistic models of permeation in ion channels. Ion channels are formed by proteins in cell membranes and provide pathways for fast and controlled flow of selected ions. This activity generates action potentials in nerves and muscles that forms the basis of all movement, sensation and thought processes. Recent determination of the crystal structure of channel proteins has enabled construction of models that can relate channel function to its structure--necessary for understanding their operation and seeking cures for diseases caused by their malfunction. This project aims to develop accurate ion-protein-water interactions for permeation models based on stochastic and molecular dynamics simulations using both classical and quantum mechanical methods.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100177
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Advanced electron paramagnetic resonance (EPR) facilities for chemical, biological and materials sciences. New instrumentation to advance national research in hydrogen fuel generation from renewable sources, new generation photo-voltaic technologies, novel polymer and other chemical materials and advanced computing systems will be provided by this project. A new high sensitivity electron paramagnetic resonance facility, located at the Australian National University, will serve researchers in the ....Advanced electron paramagnetic resonance (EPR) facilities for chemical, biological and materials sciences. New instrumentation to advance national research in hydrogen fuel generation from renewable sources, new generation photo-voltaic technologies, novel polymer and other chemical materials and advanced computing systems will be provided by this project. A new high sensitivity electron paramagnetic resonance facility, located at the Australian National University, will serve researchers in the ACT region devoted to the broad range of activities summarised above. A particular focus involves novel, biologically inspired energy systems and high efficiency solar cell technology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100004
Funder
Australian Research Council
Funding Amount
$762,800.00
Summary
Ultrafast Infrared Spectroscopy Facility. The Ultrafast Infrared Spectroscopy Facility will provide a suite of techniques spanning the visible to mid-infrared spectral regions, on time scales corresponding to the emission of light, and energy conversion in low energy advanced functional materials. Research performed with this equipment will include photonic and thermal energy conversion; nanophotonics; quantum technologies and new infrared functional materials. This facility will enhance capacit ....Ultrafast Infrared Spectroscopy Facility. The Ultrafast Infrared Spectroscopy Facility will provide a suite of techniques spanning the visible to mid-infrared spectral regions, on time scales corresponding to the emission of light, and energy conversion in low energy advanced functional materials. Research performed with this equipment will include photonic and thermal energy conversion; nanophotonics; quantum technologies and new infrared functional materials. This facility will enhance capacity in probing new materials and devices in the near and mid-infrared regions, and will increase institutional and cross-disciplinary research collaboration.Read moreRead less