The coldest region on Earth gets even colder. Studying the observable atmospheric indicators of climate change is of national interest and importance. It strengthens the Australia's participation and further recognition in this research area. This project adds to the Australia's contribution to fundamental atmospheric physics and complements work carried out by other Australian researchers. Australian science further benefits from satellite data access and analyses skills. Development of interna ....The coldest region on Earth gets even colder. Studying the observable atmospheric indicators of climate change is of national interest and importance. It strengthens the Australia's participation and further recognition in this research area. This project adds to the Australia's contribution to fundamental atmospheric physics and complements work carried out by other Australian researchers. Australian science further benefits from satellite data access and analyses skills. Development of international collaborations in this research area and involvement in several international satellite projects is important for future national atmospheric and space programs. Postgraduate training in this area provides expertise needed at many Australian organisations. Read moreRead less
Membrane structure and lipid interactions of the pore-forming toxin Equinatoxin II by NMR. The structure of Equinatoxin II, a pore-forming protein, will be determined in model cell membranes using solid-state NMR spectroscopy. The relationship of molecular structure to bioactivity and the nature of the pore-forming mechanism of this toxin will be determined. The results will aid in understanding how toxins lyse cells and could lead to the design of improved antibiotic peptides. Currently the st ....Membrane structure and lipid interactions of the pore-forming toxin Equinatoxin II by NMR. The structure of Equinatoxin II, a pore-forming protein, will be determined in model cell membranes using solid-state NMR spectroscopy. The relationship of molecular structure to bioactivity and the nature of the pore-forming mechanism of this toxin will be determined. The results will aid in understanding how toxins lyse cells and could lead to the design of improved antibiotic peptides. Currently the structure of membrane proteins are difficult to determine and the newly developed techniques used for the structural determination of this membrane-associated protein will be suitable for studying other membrane proteins and receptors of pharmaceutical importance.Read moreRead less
Optical manipulation of single molecules in nanocontainers and nanotubes. Modern medicine has benefited greatly from technological advances in instrumentation. The ability to probe and manipulate new aspects of biological function often provides unique information that can be used as the basis of new medical treatments. Recent advances in optical instrumentation and biochemical labelling has enabled the study of biological function at the single molecule level. This project proposes to develop n ....Optical manipulation of single molecules in nanocontainers and nanotubes. Modern medicine has benefited greatly from technological advances in instrumentation. The ability to probe and manipulate new aspects of biological function often provides unique information that can be used as the basis of new medical treatments. Recent advances in optical instrumentation and biochemical labelling has enabled the study of biological function at the single molecule level. This project proposes to develop new techniques in single molecule manipulation, to perform studies not easily addressable using current techniques. The proposed research will form the basis of an enabling technology for Australian researchers to make breakthroughs in biomedical research, potentially leading to improvements in healthcare.Read moreRead less
Thin Films of Oxide Ceramics. Aluminium oxide films are used extensively in the Australian industries of Protective & Decorative Coatings (examples include door-knobs and cutting-tools). The industry will be offered a remarkably simple process for preparation of high quality films. In the microelectronic industry, the uses of aluminium oxide films as a dielectric alternative to silicon dioxide has just started to emerge world - wide and this new process would make a dramatic impact with commerci ....Thin Films of Oxide Ceramics. Aluminium oxide films are used extensively in the Australian industries of Protective & Decorative Coatings (examples include door-knobs and cutting-tools). The industry will be offered a remarkably simple process for preparation of high quality films. In the microelectronic industry, the uses of aluminium oxide films as a dielectric alternative to silicon dioxide has just started to emerge world - wide and this new process would make a dramatic impact with commercial benefits for Australia. Read moreRead less
Virtual Star Clusters: The Dynamics and Evolution of Stars and Planets. Most stars are born in star clusters. When stars age
they swell and contract, change composition,
lose mass, and in dense regions they may collide.
Further, about 50% of stars are binary pairs,
and when these swell they can merge or
transfer mass. These effects dramatically
alter the lives of stars and their chemical makeup.
By combining special
purpose computers with newly developed simulation techniques,
we will ....Virtual Star Clusters: The Dynamics and Evolution of Stars and Planets. Most stars are born in star clusters. When stars age
they swell and contract, change composition,
lose mass, and in dense regions they may collide.
Further, about 50% of stars are binary pairs,
and when these swell they can merge or
transfer mass. These effects dramatically
alter the lives of stars and their chemical makeup.
By combining special
purpose computers with newly developed simulation techniques,
we will include all these effects to answer timely
and important astronomical
questions such as: can planets survive life in
a cluster? how do interactions between stars
affect the chemical enrichment of
clusters and galaxies?Read moreRead less
New and computationally feasible methods of constructing efficient and exact confidence limits from count data. Biological and health science data is commonly in the form of counts. The statistical analysis of such data should be (a) efficient i.e. it should not, in effect, throw away valuable data, (b) exact i.e. it should have precisely known statistical properties and (c) computationally feasible. Kabaila and Lloyd (1997-2001) have proposed and analysed a radically new method of confidence li ....New and computationally feasible methods of constructing efficient and exact confidence limits from count data. Biological and health science data is commonly in the form of counts. The statistical analysis of such data should be (a) efficient i.e. it should not, in effect, throw away valuable data, (b) exact i.e. it should have precisely known statistical properties and (c) computationally feasible. Kabaila and Lloyd (1997-2001) have proposed and analysed a radically new method of confidence limit construction which, for the first time, possesses all of these requirements. The purpose of the project is to establish further theoretical support for the new method, to develop efficient computational algorithms and to write easy-to-use computer programs for its practical use.Read moreRead less
Formation of Supermassive Black Holes. One of the most remarkable discoveries in astronomy is the observation that supermassive black holes, weighing as much as a billion suns, are found in the centers of galaxies, including our own Milky Way. Astronomers do not understand how these black holes came to be, or their role in the evolution of galaxies. This Discovery Project will address these issues by analysing data on supermassive black holes from the local and early universes. Black holes fasci ....Formation of Supermassive Black Holes. One of the most remarkable discoveries in astronomy is the observation that supermassive black holes, weighing as much as a billion suns, are found in the centers of galaxies, including our own Milky Way. Astronomers do not understand how these black holes came to be, or their role in the evolution of galaxies. This Discovery Project will address these issues by analysing data on supermassive black holes from the local and early universes. Black holes fascinate students both young and old. This Discovery Project will train a new generation of young Australian astronomers at the leading edge of astrophysics.
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The High Time Resolution Radio Universe. The radio sky is blanketed by charged particles in the interstellar medium that smear impulsive emissions. By constructing a new digital electronic device for the giant Parkes radio telescope we will be able to divide the radio sky up into many thousands of radio "channels", which when searched on a supercomputer, will enable us to peer into the heart of our Galaxy in search of short bursts of emission. This will be the first large-scale search of the Uni ....The High Time Resolution Radio Universe. The radio sky is blanketed by charged particles in the interstellar medium that smear impulsive emissions. By constructing a new digital electronic device for the giant Parkes radio telescope we will be able to divide the radio sky up into many thousands of radio "channels", which when searched on a supercomputer, will enable us to peer into the heart of our Galaxy in search of short bursts of emission. This will be the first large-scale search of the Universe for short bursts of radio emission. The project will pioneer real-time processing of data on a remote supercomputer via a dedicated fibre link. Read moreRead less
Formation and Evolution in the Extragalactic Universe. Understanding the formation and evolution of galaxies, quasars and clusters of galaxies remains one of the key challenges in modern cosmology. We will bring together a wide range of skills to focus on specific aspects of this problem. Major topics we will consider include: how the gas and galaxies in clusters affect one another as they evolve; how quasars are formed and evolve; how ordinary matter and dark matter are distributed in galaxi ....Formation and Evolution in the Extragalactic Universe. Understanding the formation and evolution of galaxies, quasars and clusters of galaxies remains one of the key challenges in modern cosmology. We will bring together a wide range of skills to focus on specific aspects of this problem. Major topics we will consider include: how the gas and galaxies in clusters affect one another as they evolve; how quasars are formed and evolve; how ordinary matter and dark matter are distributed in galaxies and clusters; and finally, when galaxies were formed.Read moreRead less
Cosmological simulations of future radio surveys. Future radio telescopes such as the Square Kilometre Array will create
unprecedented surveys of the Universe. This Project is designed to
increase Australia's expertise in cosmological simulations and analysis,
crucial for performing science with these surveys. It will enable
Australia to influence the scientific design of the Square Kilometre
Array and stimulate the success of its pathfinder telescopes. The
Project will create several o ....Cosmological simulations of future radio surveys. Future radio telescopes such as the Square Kilometre Array will create
unprecedented surveys of the Universe. This Project is designed to
increase Australia's expertise in cosmological simulations and analysis,
crucial for performing science with these surveys. It will enable
Australia to influence the scientific design of the Square Kilometre
Array and stimulate the success of its pathfinder telescopes. The
Project will create several opportunities for PhD projects, producing
training in a broad range of scientific, technical and computational
skills. It will also produce exciting public outreach and
visualizations that will inspire public and media interest in science
and astronomy.Read moreRead less