Discovery Early Career Researcher Award - Grant ID: DE120101503
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Design of a biologically inspired running and climbing robotic lizard. Watch any movie and it will tell you that robots are the future. The trouble is that recent attempts to build running and climbing robots have had limited success. This project explores locomotion of lizards to improve upon shortfalls in current robotic design, to build biologically inspired robots capable of running and climbing up and down walls.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100206
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
Lattice light sheet microscopy for imaging biology in real space and time. This project aims to establish a Lattice Light-Sheet Microscope (LLSM) Facility, to provide the dedicated computing infrastructure needed for terabyte-scale image acquisition and handling. Lattice light sheet microscopy allows four-dimensional imaging of live biological specimens from individual molecules to small organisms. The microscope images live specimens without phototoxicity or photobleaching, enabling prolonged i ....Lattice light sheet microscopy for imaging biology in real space and time. This project aims to establish a Lattice Light-Sheet Microscope (LLSM) Facility, to provide the dedicated computing infrastructure needed for terabyte-scale image acquisition and handling. Lattice light sheet microscopy allows four-dimensional imaging of live biological specimens from individual molecules to small organisms. The microscope images live specimens without phototoxicity or photobleaching, enabling prolonged imaging of significant physiological or biophysical events. Expected outcomes include high impact discoveries and publications in fundamental research, rapid solutions for industry-focussed projects and opportunities for collaboration, research and development. The imaging is expected to reveal key scientific insights and showcase biology to the public.Read moreRead less
Imaging the foundation of the nervous system. This Project aims to understand the formation of the neural tube; a fundamental tissue structure that generates the brain and the spinal cord. Using interdisciplinary approaches and exploiting recent advances in transgenic and imaging technologies, the Project expects to reveal the complex interplay of molecular, cellular and mechanical processes that direct neural tissue formation and cell fate specification. Outcomes from the Project include knowle ....Imaging the foundation of the nervous system. This Project aims to understand the formation of the neural tube; a fundamental tissue structure that generates the brain and the spinal cord. Using interdisciplinary approaches and exploiting recent advances in transgenic and imaging technologies, the Project expects to reveal the complex interplay of molecular, cellular and mechanical processes that direct neural tissue formation and cell fate specification. Outcomes from the Project include knowledge of previously intractable developmental processes, training of future scientists and development of international collaborations. This should provide enhanced imaging capacity, a higher quality scientific workforce and position Australia at the forefront of developmental biology.
Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100345
Funder
Australian Research Council
Funding Amount
$384,616.00
Summary
Harnessing nanotechnology to unravel extracellular vesicle heterogeneity. This project aims to develop a suite of innovative nanotechnologies to study extracellular vesicles with unprecedented depth of analysis and single particle resolution. This project expects to generate new knowledge in the emerging field of extracellular vesicle (EV) biology, as well as cell biology, using advanced nanofabrication and nanoscopic fluid flows to advance understanding of EV heterogeneity and how phenotypic va ....Harnessing nanotechnology to unravel extracellular vesicle heterogeneity. This project aims to develop a suite of innovative nanotechnologies to study extracellular vesicles with unprecedented depth of analysis and single particle resolution. This project expects to generate new knowledge in the emerging field of extracellular vesicle (EV) biology, as well as cell biology, using advanced nanofabrication and nanoscopic fluid flows to advance understanding of EV heterogeneity and how phenotypic variations affect their role in cellular processes. Expected outcomes include a universal technology platform to study extracellular vesicles and other bioparticles, with potential to deliver valuable intellectual property of commercial interest and economic benefit through technological advancements.Read moreRead less
Gut Absorption of Constrained Peptides for Local and Systemic Targeting. Aims: This project aims to investigate how peptides are absorbed across the intestinal wall and distributed to organs and fluids in a rodent model by combining bio-analysis and pharmacokinetics with high-resolution microscopy and imaging.
Significance: This project expects to generate the most comprehensive survey to date of the pathways and mechanisms of peptide absorption, biodistribution and immune cell targeting, by ....Gut Absorption of Constrained Peptides for Local and Systemic Targeting. Aims: This project aims to investigate how peptides are absorbed across the intestinal wall and distributed to organs and fluids in a rodent model by combining bio-analysis and pharmacokinetics with high-resolution microscopy and imaging.
Significance: This project expects to generate the most comprehensive survey to date of the pathways and mechanisms of peptide absorption, biodistribution and immune cell targeting, by implementing innovative approaches.
Expected Outcomes: Expected outcomes include significant new knowledge and a new multi-disciplinary platform for measuring peptide absorption.
Benefits: This should provide significant benefits by informing the future design of peptides for supplements, therapeutics and carriers. Read moreRead less
Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are inn ....Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are innovative semi-automated nephron visualisation and quantitation tools that enable efficient renal phenotyping. Techniques tailored to widely accessible preclinical research scanners are expected to accelerate research into genetic and environmental factors affecting kidney microstructure in embryonic and post-natal life.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100047
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre for Accelerated Future Crop Development . The Centre will create a new generation of leaders in the implementation of advanced gene and field technologies for the benefit of the Australian agriculture industry. We will build the workforce and foundations that will drive translation of breakthroughs in advanced breeding, phenotyping and genetic technologies into higher-yielding crops. This will increase productivity across the sector and create new markets. Our technical trai ....ARC Training Centre for Accelerated Future Crop Development . The Centre will create a new generation of leaders in the implementation of advanced gene and field technologies for the benefit of the Australian agriculture industry. We will build the workforce and foundations that will drive translation of breakthroughs in advanced breeding, phenotyping and genetic technologies into higher-yielding crops. This will increase productivity across the sector and create new markets. Our technical training programs for graduates, trainees and industry will interface with best evidence-based practices in the wider socio-economic, regulatory and environmental contexts. Coupled with community and stakeholder engagement, the Centre will redefine and secure Australia’s future in agriculture. Read moreRead less