A thermodynamic pathway to intracellular delivery. Cells transmit information through molecules. By delivering foreign molecules into cells, such as DNA and proteins, it is possible to engineer and reprogram cells just like a computer. This proposal aims to develop a novel microfluidic device for intracellular delivery. The device will work by exposing cells to rapid thermal shock to generate transient disruptions in cell membranes and thereby enable influx of foreign molecules into cells. To un ....A thermodynamic pathway to intracellular delivery. Cells transmit information through molecules. By delivering foreign molecules into cells, such as DNA and proteins, it is possible to engineer and reprogram cells just like a computer. This proposal aims to develop a novel microfluidic device for intracellular delivery. The device will work by exposing cells to rapid thermal shock to generate transient disruptions in cell membranes and thereby enable influx of foreign molecules into cells. To understand how the method can be optimized, the thermodynamic pathway of membrane disruption will be investigated at a single cell level. The methods and insights arising from this project could eventually lead to novel, patentable and lower-cost health technologies.Read moreRead less
Electric field effects on cochlear tissues. The project aims to solve the underlying biology of how electricity flows through the cochlear tissues, where and how electrical stimulation excites the auditory neurons, and what the effects of sustained electrical stimulation are on the nerve fibre growth and function. The research aims to show how electric fields can be controlled in the cochlea, and how auditory nerve fibres are affected at the cellular and molecular level. The long-term aim is to ....Electric field effects on cochlear tissues. The project aims to solve the underlying biology of how electricity flows through the cochlear tissues, where and how electrical stimulation excites the auditory neurons, and what the effects of sustained electrical stimulation are on the nerve fibre growth and function. The research aims to show how electric fields can be controlled in the cochlea, and how auditory nerve fibres are affected at the cellular and molecular level. The long-term aim is to utilise these findings to improve the control of neuronal excitability, for development of interfaces with the nervous system.Read moreRead less
Femoral microarchitecture, strength and locomotion in adult people. This project aims at unravelling the load bearing capacity of human femora microarchitecture. The project will quantify the relationship between geometry, microarchitecture, strain and strength in adult people during normal and accidental motor tasks using micro-computed-tomography images, motion data, supercomputing technology and multivariate statistic. It will benefit the design of novel implantable devices, enhance exercise ....Femoral microarchitecture, strength and locomotion in adult people. This project aims at unravelling the load bearing capacity of human femora microarchitecture. The project will quantify the relationship between geometry, microarchitecture, strain and strength in adult people during normal and accidental motor tasks using micro-computed-tomography images, motion data, supercomputing technology and multivariate statistic. It will benefit the design of novel implantable devices, enhance exercise therapies and diagnostic techniques for promoting hip strength. The project will contribute to the engineering of biological tissue and the development of high-strength and light-weight bio-inspired materials.Read moreRead less
Spatio-temporal activation of genes in cells and mice. This project aims to develop novel genetic methods and instrumentation for the local, rapid and reversible activation of genes in cells and mice. This project expects to generate highly innovative light- and sound-based technologies that will permit to study living systems on the gene-level with unprecedented precision. Expected outcomes include new research and technology capacity to broadly address fundamental biological questions and to c ....Spatio-temporal activation of genes in cells and mice. This project aims to develop novel genetic methods and instrumentation for the local, rapid and reversible activation of genes in cells and mice. This project expects to generate highly innovative light- and sound-based technologies that will permit to study living systems on the gene-level with unprecedented precision. Expected outcomes include new research and technology capacity to broadly address fundamental biological questions and to create new applied processes. This project intends to provide significant benefits, such as enhanced knowledge generation, multidisciplinary training opportunities and patentable technologies.Read moreRead less
Nonlinear viscoelastic properties of paediatric soft tissues throughout development. This project will determine how the soft tissues of the human body change during normal development, and how these changes affect their response to mechanical forces. This data will be useful for understanding childhood injury mechanisms, and how diseases affect children's soft tissues.
Understanding self-organising tissues. This project will discover how an organ can form from a mixture of component cells by 'self-organisation'. Understanding of how this can occur, could potentially be applied to the bioengineering of organs from component cells.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100174
Funder
Australian Research Council
Funding Amount
$800,000.00
Summary
Innovative synchrotron science - program for access to the Australian National Beamline Facility and cutting-edge beamlines at international synchrotrons. Synchrotron science dramatically affects the community through the innovative scientific, engineering and medical research outcomes it produces. This program for access to synchrotron beamlines is aimed at enhancing Australia's high international standing in synchrotron science and will have many flow-on effects in areas such as health and ind ....Innovative synchrotron science - program for access to the Australian National Beamline Facility and cutting-edge beamlines at international synchrotrons. Synchrotron science dramatically affects the community through the innovative scientific, engineering and medical research outcomes it produces. This program for access to synchrotron beamlines is aimed at enhancing Australia's high international standing in synchrotron science and will have many flow-on effects in areas such as health and industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100003
Funder
Australian Research Council
Funding Amount
$318,900.00
Summary
Vector network analyser suite for advanced terahertz materials and devices. This project aims to establish terahertz measurement capabilities to further Australia's strength and momentum in terahertz research. This will comprise of two terahertz extension modules, working with a dedicated vector-network analyser, and high-precision probes and probe station. The project will enable point-feeding, monochromatic, coherent, and fine spectral-resolution measurement at an atmospheric window of 220-330 ....Vector network analyser suite for advanced terahertz materials and devices. This project aims to establish terahertz measurement capabilities to further Australia's strength and momentum in terahertz research. This will comprise of two terahertz extension modules, working with a dedicated vector-network analyser, and high-precision probes and probe station. The project will enable point-feeding, monochromatic, coherent, and fine spectral-resolution measurement at an atmospheric window of 220-330 GHz. The capabilities are essential for development of two-dimensional materials, active components, waveguides, and antennas towards a common goal of efficient integrated terahertz devices and systems. The project will serve emerging terahertz applications including standoff imaging and short-range high-speed data transmission. This will have broad impact in the areas of surveillance, biomedicine, security, and public safety and well-being.Read moreRead less
Engineering high-efficiency all-dielectric antennas for terahertz channels. This project aims to create unconventional antenna platforms to support terahertz links. The project expects to deliver high-efficiency, high-gain dielectric resonator antennas and dielectric rod antenna arrays fed by dielectric wave-guides. The expected outcomes of this project will build critical components for future terahertz communication infrastructure. These antennas will support demands in point-to-point wireless ....Engineering high-efficiency all-dielectric antennas for terahertz channels. This project aims to create unconventional antenna platforms to support terahertz links. The project expects to deliver high-efficiency, high-gain dielectric resonator antennas and dielectric rod antenna arrays fed by dielectric wave-guides. The expected outcomes of this project will build critical components for future terahertz communication infrastructure. These antennas will support demands in point-to-point wireless transmission between mobile base stations, within data centres, and at information kiosks.Read moreRead less
Wideband Strongly-Truncated Composite Cavity-Resonator Antennas. A rapidly growing demand for fast wireless services calls for wideband communication systems with wideband antennas, which are compact, aesthetically appealing and inexpensive, yet have good performance. With novel concepts, this project aims to produce a new class of antennas that deliver impressive performance (bandwidth and gain) while taking up a dramatically reduced area in a way that was impossible before, increasing a figure ....Wideband Strongly-Truncated Composite Cavity-Resonator Antennas. A rapidly growing demand for fast wireless services calls for wideband communication systems with wideband antennas, which are compact, aesthetically appealing and inexpensive, yet have good performance. With novel concepts, this project aims to produce a new class of antennas that deliver impressive performance (bandwidth and gain) while taking up a dramatically reduced area in a way that was impossible before, increasing a figure-of-merit to up to seven times the state-of-the-art. Their planar geometry and simplicity lead to low cost. This is expected to create new knowledge, design methods and examples, prototypes, test results and guidelines required to design, optimise and make these versatile antennas for emerging robust broadband wireless systems.Read moreRead less