Plasticity in placental vasculature and the evolution of viviparity in lizards. This cross-disciplinary research will provide thorough understanding of the reproductive physiology of animals with different forms of reproduction, information critical for conservation and management of Australia's biodiversity. Australia's unique reptiles provide the best animal system in the world for research in this area. Our research on maternal-embryonic interactions in this animal model has direct implicatio ....Plasticity in placental vasculature and the evolution of viviparity in lizards. This cross-disciplinary research will provide thorough understanding of the reproductive physiology of animals with different forms of reproduction, information critical for conservation and management of Australia's biodiversity. Australia's unique reptiles provide the best animal system in the world for research in this area. Our research on maternal-embryonic interactions in this animal model has direct implications for understanding some medical disorders, such as human angiogenic disorders. The research will strengthen ties internationally through research in South Africa, and provide training in combined biological and medical technologies. It will maintain Australia's long-term leadership in this area of research.Read moreRead less
Calcium regulation in the skeletal muscle triad and along the fibre. The fundamental role of skeletal muscle is posture and movement. Alterations in the normal way calcium regulates skeletal muscle function in fatigue, age and disease states causes loss of normal function. Preventing or controlling these changes is a key therapeutic aim. However, we currently lack full understanding of key mechanisms of calcium regulation in healthy skeletal muscle. This project will define key aspects of cal ....Calcium regulation in the skeletal muscle triad and along the fibre. The fundamental role of skeletal muscle is posture and movement. Alterations in the normal way calcium regulates skeletal muscle function in fatigue, age and disease states causes loss of normal function. Preventing or controlling these changes is a key therapeutic aim. However, we currently lack full understanding of key mechanisms of calcium regulation in healthy skeletal muscle. This project will define key aspects of calcium regulation that could be crucial to developing targets for improving function of skeletal muscle under stressed states.Read moreRead less
Competition between regulatory processes in Amphibians: Testing the effects of physical and physiological factors on thermoregulation and hydroregulation. Regulation of body temperature is important for many animals, and it influences processes such as growth and reproduction. However, it is not clear to what extent wet-skinned animals can control body temperature because of evaporation. Understanding this about frogs is crucial to understanding their habitat requirements and the effects of clim ....Competition between regulatory processes in Amphibians: Testing the effects of physical and physiological factors on thermoregulation and hydroregulation. Regulation of body temperature is important for many animals, and it influences processes such as growth and reproduction. However, it is not clear to what extent wet-skinned animals can control body temperature because of evaporation. Understanding this about frogs is crucial to understanding their habitat requirements and the effects of climate change, habitat modification, and the invasion of cane toads on their populations. Amphibians are in decline worldwide, and research into the basic ways that these animals interact with the physical environment is needed before effective management plans can be produced. The unique physiological characteristics of Australian frogs make this is the best place in the world to do this research.Read moreRead less
Do frogs hydroregulate? Regulation versus tolerance of thermal and hydric states. Amphibians are in decline in Australia and worldwide. Frogs are a middle link in terrestrial and aquatic food chains (as predators and prey) so are important for the sustainability of Australia's biodiversity and as indicators of environmental problems. Basic research about the ways Australian frogs interact with the physical environment to balance body water and temperature is crucial to predicting the effects of ....Do frogs hydroregulate? Regulation versus tolerance of thermal and hydric states. Amphibians are in decline in Australia and worldwide. Frogs are a middle link in terrestrial and aquatic food chains (as predators and prey) so are important for the sustainability of Australia's biodiversity and as indicators of environmental problems. Basic research about the ways Australian frogs interact with the physical environment to balance body water and temperature is crucial to predicting the effects of climate change or habitat modification on frogs. This basic information is needed to produce effective conservation plans for native frogs and management plans for invasive cane toads. We will train students in techniques and concepts in ecology, conservation biology, and animal physiology.Read moreRead less
Responses of reptiles to fluctuating thermal environments: behaviour or biochemistry? I propose a conceptual shift in the way thermal physiology of reptiles is interpreted, questioning the predominant role of behaviour in reptilian thermoregulation. I will test the hypothesis that changes in cellular biochemistry are an important mechanism by which reptiles respond to environmental fluctuations. I will determine the relationship between metabolic enzyme activity and performance functions, and ....Responses of reptiles to fluctuating thermal environments: behaviour or biochemistry? I propose a conceptual shift in the way thermal physiology of reptiles is interpreted, questioning the predominant role of behaviour in reptilian thermoregulation. I will test the hypothesis that changes in cellular biochemistry are an important mechanism by which reptiles respond to environmental fluctuations. I will determine the relationship between metabolic enzyme activity and performance functions, and the results may call for a re-assessment of current concepts such as the notion that reptiles must achieve "preferred" body temperatures to maintain performance.Read moreRead less
The inhibition of muscle disuse atrophy in burrowing frogs. Prolonged muscle disuse, as a consequence of limb immobilisation, extended bed-rest or space travel, can lead to pathological changes resulting in muscle wasting. By examining a unique Australian frog that burrows underground and remains immobile for 9-12 months, and which shows no muscle wasting, we will significantly advance our understanding of the physiological mechanisms that inhibit muscle atrophy.
Benefits of conducting this r ....The inhibition of muscle disuse atrophy in burrowing frogs. Prolonged muscle disuse, as a consequence of limb immobilisation, extended bed-rest or space travel, can lead to pathological changes resulting in muscle wasting. By examining a unique Australian frog that burrows underground and remains immobile for 9-12 months, and which shows no muscle wasting, we will significantly advance our understanding of the physiological mechanisms that inhibit muscle atrophy.
Benefits of conducting this research will include:
- understanding the role of antioxidants and endogenous opioids in reducing muscle wasting
- training of postgraduate students
- stimulating collaboration between The University of Queensland and CSIRO Livestock Industries.Read moreRead less
Food supply, diet and membrane lipids and the determination of metabolic rate. There are two types of polyunsaturated fatty acids (omega-3 and omega-6), which are both essential in the diet. This project will examine whether our current diet has a good balance of these two classes of fatty acids. It will examine the hypothesis that we do not have enough omega-3 polyunsaturates in our modern diet and that this imbalance has important consequences for metabolism and health. It will give insight in ....Food supply, diet and membrane lipids and the determination of metabolic rate. There are two types of polyunsaturated fatty acids (omega-3 and omega-6), which are both essential in the diet. This project will examine whether our current diet has a good balance of these two classes of fatty acids. It will examine the hypothesis that we do not have enough omega-3 polyunsaturates in our modern diet and that this imbalance has important consequences for metabolism and health. It will give insight into a relatively unappreciated cause of the current obesity epidemic and likely result in new strategies to combat this problem. It will have implications for other important health issues (such as depression) as well as for the food supply of Australia. Read moreRead less
The role of dopamine in the regulation of worker sterility in the honey bee. This project will open new doors into the knowledge of honey bees' sterility. We will not only show that certain genes control honey bee sterility but also that there is interactions between these genes and environmental cues such as the pheromones released by the queen. The project will provide significant material for a better understanding of honey bees society. Honey bees remain the most important pollinator world w ....The role of dopamine in the regulation of worker sterility in the honey bee. This project will open new doors into the knowledge of honey bees' sterility. We will not only show that certain genes control honey bee sterility but also that there is interactions between these genes and environmental cues such as the pheromones released by the queen. The project will provide significant material for a better understanding of honey bees society. Honey bees remain the most important pollinator world wide, and their conservation is a major concern both to agriculturalists and the general public. The project will be of immense scientific interest, and likely to be regarded as a major breakthrough. The project will also foster a strong intellectual collaboration between New Zealand and Australia.Read moreRead less
Evolution of viviparity in reptiles: the fundamental role of junctional complexes. This project utilises unique Australian reptile fauna to understand global questions in fundamental biology. We will discover basic biological information on native species, which will be important in future conservation of Australian ecosystems and animals and ultimately in helping to maintain Australia's biodiversity. The project also provides training opportunities for graduate and undergraduate students in ....Evolution of viviparity in reptiles: the fundamental role of junctional complexes. This project utilises unique Australian reptile fauna to understand global questions in fundamental biology. We will discover basic biological information on native species, which will be important in future conservation of Australian ecosystems and animals and ultimately in helping to maintain Australia's biodiversity. The project also provides training opportunities for graduate and undergraduate students in several different research methods that are widely applicable in the more general Australian workforce. Because the research work is genuinely cross-disciplinary research, its findings are applicable to both biological and medically oriented technologies.Read moreRead less
Determinants of metabolic rate in animals. The metabolic rate of an animal represents its fundamental "cost of living" and varies dramatically (>100-fold) between different vertebrate species. We have proposed the "membrane pacemaker theory" to explain this variation and currently this is the only mechanistic explanation of metabolic variation between species. It has received significant international interest. A species metabolic rate and its maximum lifespan are connected but the precise mecha ....Determinants of metabolic rate in animals. The metabolic rate of an animal represents its fundamental "cost of living" and varies dramatically (>100-fold) between different vertebrate species. We have proposed the "membrane pacemaker theory" to explain this variation and currently this is the only mechanistic explanation of metabolic variation between species. It has received significant international interest. A species metabolic rate and its maximum lifespan are connected but the precise mechanistic link between them is unknown. We will investigate the mechanisms underlying the "membrane pacemaker theory" as an explanation of the metabolic rates of vertebrate species and its role in the determination of maximum lifespan.Read moreRead less