Cell-cell fusion is critical for the development and transport capacity of the placenta during pregnancy. Impairments in this process occur in pregnancy complications such as preeclampsia (PE). We have identified a novel pathway (LY6E) regulating placental cell-cell fusion which is also dysregulated in human pregnancies complicated by PE. In the current proposal we will investigate the mechanisms by which LY6E mediates cell-cell fusion and examine its role in the development of PE.
Novel Molecular Pathways Of The Placental Renin Angiotensin System In Preeclampsia
Funder
National Health and Medical Research Council
Funding Amount
$323,524.00
Summary
Preeclampsia (PE) is a common and potentially life-threatening pregnancy disorder of pregnancy which originates in the early placenta. We will look into new interactions between molecules that determine how early cells establish a functioning placenta. Detection and early treatment of abnormal placental function can prevent PE before serious complications develop.