Connecting soil nitrogen and plant uptake for greener agriculture. This project will use synthetic organic chemistry, biochemistry, root and rhizosphere biology and rhizosphere modelling to establish detailed mechanistic knowledge of the nitrogen (N) transport and uptake processes at the soil-root interface to develop new, efficient urease and nitrification inhibitors for reliable provision of N to the plant/root system. The reduction of excessive N fertilisation has significant environmental be ....Connecting soil nitrogen and plant uptake for greener agriculture. This project will use synthetic organic chemistry, biochemistry, root and rhizosphere biology and rhizosphere modelling to establish detailed mechanistic knowledge of the nitrogen (N) transport and uptake processes at the soil-root interface to develop new, efficient urease and nitrification inhibitors for reliable provision of N to the plant/root system. The reduction of excessive N fertilisation has significant environmental benefits by reducing greenhouse gas emissions and water pollution. This project will lead to a breakthrough for the triple challenge of food security, environmental degradation and climate change, while improving plant productivity and increasing the profitability of agriculture through lower fertiliser costs.Read moreRead less
Chemically re-engineering bioactive natural products using fragment based drug design. Current drug and agrichemical discovery technologies are under immense pressure to meet the future pharmaceutical and agriculture demand created by population growth. This project will develop a novel technology concept that re-engineers the chemical features of bioactive natural products optimising medicine and agrichemical discovery.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989351
Funder
Australian Research Council
Funding Amount
$425,000.00
Summary
High Resolution Mass Spectrometry Facility. The research that will be supported by this vital infrastructure impacts on the sustainable environment through understanding the process of seed germination and the human condition through new drugs for the treatment of cancer and Parkinson's disease. Fundamental science will also be addressed particularly in the fields of photonics and the nature of interactions between matter.
Preparation of Photo-Affinity Molecular Probes for the Identification of Gibberellin Receptors. Bioactive gibberellins affect numerous processes during plant growth and development, including seed germination, leaf expansion, stem elongation, flowering and fruit development. However, only very limited information is available regarding their mode of action at the molecular level. The central aim of the project is to prepare a family of photo-affinity molecular probes based on the gibberellin m ....Preparation of Photo-Affinity Molecular Probes for the Identification of Gibberellin Receptors. Bioactive gibberellins affect numerous processes during plant growth and development, including seed germination, leaf expansion, stem elongation, flowering and fruit development. However, only very limited information is available regarding their mode of action at the molecular level. The central aim of the project is to prepare a family of photo-affinity molecular probes based on the gibberellin molecule that will be designed to provide critical information on the location and structure of gibberellin receptors. Screening of the probes for potential effectiveness will be determined initially by the measurement of alpha-amylase produced in a standard barley aleurone assay.Read moreRead less
Marine Natural Products as Sources of Agrochemicals - The Variolins. The aim of this project is the identification of new classes of agrochemicals with better pest resistance and environmental profiles. The proposed partnership with a major international chemical manufacturing organization will allow access to state-of-the-art techniques for the screening and development of novel compounds as agents for the control of pests that affect many major agricultural crops relevant to Australia's econo ....Marine Natural Products as Sources of Agrochemicals - The Variolins. The aim of this project is the identification of new classes of agrochemicals with better pest resistance and environmental profiles. The proposed partnership with a major international chemical manufacturing organization will allow access to state-of-the-art techniques for the screening and development of novel compounds as agents for the control of pests that affect many major agricultural crops relevant to Australia's economy. Australian graduate students will experience the operations of one of the world's biggest chemical manufacturers. The derivation of agrochemicals from marine sources will promote further recognition of the value of marine ecosystems around Australia.Read moreRead less
Synthesis and Biological Evaluation of Australian Sponge Metabolites. The development of concise and flexible syntheses of Australian marine natural products and analogues of ecological/therapeutic significance will emerge. Such activities will lead to the identification and evaluation of molecular entities of value in managing marine environments and help to enhance chemical synthesis capacity in Australia.