The Molecular Determinants Of Immunological Tolerance
Funder
National Health and Medical Research Council
Funding Amount
$473,477.00
Summary
Autoimmune diseases, such as type I diabetes and multiple sclerosis, are debilitating disorders that impose a massive toll on wellbeing in Australia and worldwide. This fellowship will support research aimed at determining the genes and mechanisms that control autoimmunity. New technologies will be brought to bear to track immune cells throughout their development, maturity and malfunction in disease settings. We aim to uncover new therapeutic targets to prevent and reverse autoimmune disease.
Methylation Sensitive Genes And The Transition To Allergic Disease: A Twin Study
Funder
National Health and Medical Research Council
Funding Amount
$493,843.00
Summary
Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in ....Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in children.Read moreRead less
Characterization Of HOXA-expressing Human Haematopoietic Cells Generated From Embryonic Stem Cells
Funder
National Health and Medical Research Council
Funding Amount
$622,464.00
Summary
Blood stem cell transplants are used for treating a range of human blood disorders such as leukaemias. However, for many patients, suitable donors cannot be found. We are searching for ways in which embryonic stem cells can be turned into blood stem cells in the laboratory to provide a new source of these cells that could then be used to treat patients.
Transcriptional Regulation Of Definitive Hematopoietic Development In Humans
Funder
National Health and Medical Research Council
Funding Amount
$800,036.00
Summary
Blood stem cell transplantation is a vital therapy for patients with leukaemia following chemotherapy or for patients with bone marrow failure. Because many patients lack a donor, there is a need for an alternate source of stem cells, such as human pluripotent stem cells. During development, blood cells are formed from the blood vessel wall, or endothelium. In this project, we will study the regulation of this process in order to more efficiently make human blood cells in the laboratory.
The New Dimensions of the Quantum Universe. This Fellowship will help build and strengthen significant world-class research capacity at the frontier of fundamental science. More students will be motivated to pursue careers in science, increasing the number of talented, world-class science graduates in Australia. It will forge strong research links both locally and internationally so as to enhance existing networks and create new ones. It will greatly enhance Australia's standing in particle phys ....The New Dimensions of the Quantum Universe. This Fellowship will help build and strengthen significant world-class research capacity at the frontier of fundamental science. More students will be motivated to pursue careers in science, increasing the number of talented, world-class science graduates in Australia. It will forge strong research links both locally and internationally so as to enhance existing networks and create new ones. It will greatly enhance Australia's standing in particle physics, the epitome of Big Science, and garner new respect from one of the world's most influential scientific communities. Having this kind of world-class research in Australia, will also help foster public education and advance the public understanding of fundamental science.
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Branes and unification. This project will explore theories which hypothesis that our universe is a 3-dimensional mem-(brane) residing in higher dimensional space. We will construct completely realistic theories and find ways to test them experimentally. This project is at the forefront of international developments in our understanding of the universe - an area that has grown in importance following the construction of the Large Hadron Collider at the European Giant accelerator laboraroty. The p ....Branes and unification. This project will explore theories which hypothesis that our universe is a 3-dimensional mem-(brane) residing in higher dimensional space. We will construct completely realistic theories and find ways to test them experimentally. This project is at the forefront of international developments in our understanding of the universe - an area that has grown in importance following the construction of the Large Hadron Collider at the European Giant accelerator laboraroty. The project will expose postgraduate students to exciting developments in this fascinating field pf physics.Read moreRead less
Particle physics and cosmology of neutrinos. Neutrinos are a particularly interesting class of elementary particle. The Standard Model of particle physics sees neutrinos as having exactly zero mass. However, recent experimental data have all but demonstrated that massless neutrinos are inconsistent with observations. If neutrinos have mass, then quantum mechanics allows them to oscillate between the different neutrino types as they propagate through space. Nonzero neutrino masses and the associa ....Particle physics and cosmology of neutrinos. Neutrinos are a particularly interesting class of elementary particle. The Standard Model of particle physics sees neutrinos as having exactly zero mass. However, recent experimental data have all but demonstrated that massless neutrinos are inconsistent with observations. If neutrinos have mass, then quantum mechanics allows them to oscillate between the different neutrino types as they propagate through space. Nonzero neutrino masses and the associated oscillations lead to important new physics in the elementary particle domain and in cosmology. This project will explore the implications of neutrino oscillations in diverse areas in particle physics and cosmology.Read moreRead less
The Origin of Mass at the Large Hadron Collider. The Large Hadron Collider is an enormous worldwide effort to understand the building blocks of the Universe. This project will help strengthen world-class research capacity in one of the most exciting frontiers of basic research. It will excite more high-achieving students to pursue careers in science increasing the number of talented graduates in Australia. In addition the big fundamental questions addressed in this research are of great fascin ....The Origin of Mass at the Large Hadron Collider. The Large Hadron Collider is an enormous worldwide effort to understand the building blocks of the Universe. This project will help strengthen world-class research capacity in one of the most exciting frontiers of basic research. It will excite more high-achieving students to pursue careers in science increasing the number of talented graduates in Australia. In addition the big fundamental questions addressed in this research are of great fascination to the general public and will help to further advance the public education of science.Read moreRead less
Origin of the Mass. A hundred metres below ground, under the French-Swiss border, scientists are preparing to travel back in time to study matter as it was in the first fractions of a second after the beginning of the Universe. They are building the world's largest scientific instrument to help reveal how this primordial matter developed into the building blocks that form the great diversity of today. Australian physicists are preparing to extract the few fundamental particles that will explain ....Origin of the Mass. A hundred metres below ground, under the French-Swiss border, scientists are preparing to travel back in time to study matter as it was in the first fractions of a second after the beginning of the Universe. They are building the world's largest scientific instrument to help reveal how this primordial matter developed into the building blocks that form the great diversity of today. Australian physicists are preparing to extract the few fundamental particles that will explain the origin of the mass from the debris of billions of proton collisions. While solving the major issue confronting particle physics today, we will train students who will subsequently apply their skills in fields as diverse as science, medicine, industry and finance.Read moreRead less