Functional And Molecular Profiling Of Platelet Hyperactivity In Diabetes - Uncovering Dysregulated And Targetable Pathways For Potential Treatments
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
The major cause of death in diabetes is cardiovascular disease. Diabetic patients are more likely to have hardening of their arteries, and an increased propensity to form pathological blood clots. I propose to characterise platelet “hyperactivity” in diabetes both at a functional and molecular level. This unique approach aims to identify the underlying mechanism of platelet hyperactivity which may be targeted in future treatments.
Studying Coronary Physiology Within Human Coronary Arteries Using Computational Fluid Dynamics
Funder
National Health and Medical Research Council
Funding Amount
$383,834.00
Summary
The aim of this project is to combine the recent technological advances within the individual fields of coronary physiology, three-dimensional coronary angiography, and computational fluid dynamics to develop a novel method to calculate realistic coronary blood flow. This technique will provide a simple and clinically applicable method to measure physiological parameters such as microcirculatory resistance and shear stress within _live� human coronary arteries.
The Identification Of Thoracic Targets For Prevention And Intervention In Bronchopulmonary Dysplasia
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
The persistence of breathing problems from infancy to later life is a complication of premature birth with lifelong consequences. Breathing problems often occur together with lung disease, but prematurity can also affect heart and blood vessel development, and weakness of the main breathing muscle. We will find out how much the heart, lungs and diaphragm contribute to breathing problems in babies; helping us to better predict, diagnose and treat severe breathing problems in babies born preterm.