Modelling human brain development with stem cells and biomaterials. With limited resources to directly study and advance our understanding of human neural development, this
proposal will establish models of 4 key stages. Employing innovative, interdisciplinary approaches, biomaterials will be fabricated to provide structural and chemical support for human stem cells during: (i) neural induction, (ii) specification into neuronal progenitor subpopulations, (iii) neuronal maturation and integration ....Modelling human brain development with stem cells and biomaterials. With limited resources to directly study and advance our understanding of human neural development, this
proposal will establish models of 4 key stages. Employing innovative, interdisciplinary approaches, biomaterials will be fabricated to provide structural and chemical support for human stem cells during: (i) neural induction, (ii) specification into neuronal progenitor subpopulations, (iii) neuronal maturation and integration into complex neural networks as well as, (iv) the organisation of neurons into larger 3-dimensional brain structures, namely folding of the human cortex. Further, biomaterials developed here have commercialisation potential, targeted at standardizing the culturing of human stem cells to defined neural populations.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100001
Funder
Australian Research Council
Funding Amount
$875,000.00
Summary
A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected out ....A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected outcomes to include the generation of new knowledge of major biological systems, including the immune system and the nervous system. This will provide significant benefits to fundamental interdisciplinary research into immunology, infectious disease, neuroscience, mechanobiology and engineering.Read moreRead less
Mass transport in high entropy alloys. This project aims to understand mass transport in high entropy alloys. Alloys of 5 to 13 components have technologically attractive mechanical properties. A knowledge of mass transport could control their stabilities and optimise their properties. This project will develop an atomistic theory and a phenomenological method for rapidly performing experiments, and experiment on two key high entropy alloys. The outcome of this research will be an in-depth under ....Mass transport in high entropy alloys. This project aims to understand mass transport in high entropy alloys. Alloys of 5 to 13 components have technologically attractive mechanical properties. A knowledge of mass transport could control their stabilities and optimise their properties. This project will develop an atomistic theory and a phenomenological method for rapidly performing experiments, and experiment on two key high entropy alloys. The outcome of this research will be an in-depth understanding of mass transport that is expected to fast-track these alloys to commercial uptake.Read moreRead less
Understanding platinum dissolution in biomedical stimulating electrodes. Platinum is the main material used in electrodes for neurostimulators like the cochlear implant. Platinum electrodes can experience dissolution during implantation, which can impact on their function. The mechanisms governing this dissolution process are complex and still not fully understood. This research aims to understand the chemical, electrical and biological factors that impact on platinum dissolution in electrodes. ....Understanding platinum dissolution in biomedical stimulating electrodes. Platinum is the main material used in electrodes for neurostimulators like the cochlear implant. Platinum electrodes can experience dissolution during implantation, which can impact on their function. The mechanisms governing this dissolution process are complex and still not fully understood. This research aims to understand the chemical, electrical and biological factors that impact on platinum dissolution in electrodes. It will also develop new 3D models to simulate conditions in the human body for more rapid testing of electrodes. The new knowledge generated will improve the accuracy of predictions of platinum dissolution, develop new approaches for minimising dissolution, and contribute to reducing need for animal experimentation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100200
Funder
Australian Research Council
Funding Amount
$270,427.00
Summary
AutoStem: a high performance, automated stem cell bioengineering facility. This project aims to establish an automated stem cell bioengineering ("AutoStem") facility that will enable critical insights into the molecular mechanisms that underly the loss in stem cell function and tissue homeostasis as we age. The AutoStem facility expects to lead to the discovery of the key drivers of stem cell ageing and the development of novel technological solutions to maintain tissue function with age. The o ....AutoStem: a high performance, automated stem cell bioengineering facility. This project aims to establish an automated stem cell bioengineering ("AutoStem") facility that will enable critical insights into the molecular mechanisms that underly the loss in stem cell function and tissue homeostasis as we age. The AutoStem facility expects to lead to the discovery of the key drivers of stem cell ageing and the development of novel technological solutions to maintain tissue function with age. The outcomes produced from the AutoStem facility will have significant economic and social benefits in enabling healthy ageing and increased productivity for an ageing Australia.Read moreRead less
Aberration-corrected atom probe tomography for materials engineering. Observing atomic-scale structure (AS) is key to unlocking advanced materials science and engineering (MSE).
Aims: We aim to (1) develop software that will enable the accurate observation of atoms in a material, and (2) apply this new software to additive manufactured alloys and quantum computing materials.
Significance: We expect to complete aberration-corrected atom probe tomography capability for the first time international ....Aberration-corrected atom probe tomography for materials engineering. Observing atomic-scale structure (AS) is key to unlocking advanced materials science and engineering (MSE).
Aims: We aim to (1) develop software that will enable the accurate observation of atoms in a material, and (2) apply this new software to additive manufactured alloys and quantum computing materials.
Significance: We expect to complete aberration-corrected atom probe tomography capability for the first time internationally. We intend to gain better insights into some longstanding questions in MSE that can only be answered by accurately observing AS.
Benefits: By making the outcomes commercially available, we aspire to improve consistency in the quality of products, and increased yield, that result from manufacturing processes.Read moreRead less
Understanding self-organising tissues. This project will discover how an organ can form from a mixture of component cells by 'self-organisation'. Understanding of how this can occur, could potentially be applied to the bioengineering of organs from component cells.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100209
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
A 4-D X-Ray Microscopy Laboratory. We propose a multiscale X-Ray Microscopy (XRM) laboratory for time-lapse imaging. High flux X-Ray Microscopy (XRM) with resolutions from cm- down to Angstrom-scale is proposed by bringing Synchrotron technology to the laboratory. The laboratory aims at revolutionising imaging capability of evolving structures and physical properties in inorganic and organic materials used in mineral, energy, manufacturing, bioengineering, aerospace, automotive and a range of ot ....A 4-D X-Ray Microscopy Laboratory. We propose a multiscale X-Ray Microscopy (XRM) laboratory for time-lapse imaging. High flux X-Ray Microscopy (XRM) with resolutions from cm- down to Angstrom-scale is proposed by bringing Synchrotron technology to the laboratory. The laboratory aims at revolutionising imaging capability of evolving structures and physical properties in inorganic and organic materials used in mineral, energy, manufacturing, bioengineering, aerospace, automotive and a range of other industries. The expected outcome is an integration of XRM between USyd, UNSW, UQ, QUT and ANSTO. The added benefit is to perform long time scale XRM experiments with collaborations in the material- manufacturing, geo- and biomedical sciences and many engineering disciplines.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100109
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
A multiscale electrochemical, magnetoelectric and electromechanical characterisation facility for advanced materials and devices. This infrastructure for advanced materials characterisation will boost Australia's capabilities in creating functional materials and nanostructured interfaces. It will yield new materials and functional interfaces with the best performance for applications in nanotechnology, communications, the environment and security.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100036
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
A customised triple-beam microscope for precise fabricating/characterising . This project aims to establish a customised triple-beam microscope to enable precise fabrication and polishing (using ion beams) and characterisation (using electron beam) of a wide range of advanced materials. It will provide solutions to prepare ultra-high quality and artefact-free specimens for transmission electron microscopy studies, and allow fabrication of unique nanostructures and nanostructured templates for hi ....A customised triple-beam microscope for precise fabricating/characterising . This project aims to establish a customised triple-beam microscope to enable precise fabrication and polishing (using ion beams) and characterisation (using electron beam) of a wide range of advanced materials. It will provide solutions to prepare ultra-high quality and artefact-free specimens for transmission electron microscopy studies, and allow fabrication of unique nanostructures and nanostructured templates for high-performance applications. The customised features of the proposed instrument are the first of its kind in Australia. The new knowledge developed through this project will significantly impact on scientific insights and practical applications of new materials related to physics, chemistry, biology, geology and engineering.Read moreRead less