Understanding how mitochondria divide. This project aims to investigate the molecular mechanism by which mitochondria divide. Mitochondria are the powerhouse within our cells, and they grow and divide in our cells to ensure that they are transferred to daughter cells and also so that older mitochondria can be turned over. The project plans to build on the discovery of mitochondrial membrane proteins that are involved in fission. The results of the project could provide fundamental new knowledge ....Understanding how mitochondria divide. This project aims to investigate the molecular mechanism by which mitochondria divide. Mitochondria are the powerhouse within our cells, and they grow and divide in our cells to ensure that they are transferred to daughter cells and also so that older mitochondria can be turned over. The project plans to build on the discovery of mitochondrial membrane proteins that are involved in fission. The results of the project could provide fundamental new knowledge into how the mitochondrial division machine assembles and how mitochondrial fate is determined.Read moreRead less
Mapping networks governing cell state plasticity: how, where and when? Single cell organisms are the basic unit of life, yet, if they had not developed the ability to change cell states we would not exist today. Changing cell states lies at the core of almost every developmental and disease process in multicellular organisms. Building upon our fundamental discovery that stem cells and non-stem cells readily interconvert, we will now incorporate innovative cell systems and the development of our ....Mapping networks governing cell state plasticity: how, where and when? Single cell organisms are the basic unit of life, yet, if they had not developed the ability to change cell states we would not exist today. Changing cell states lies at the core of almost every developmental and disease process in multicellular organisms. Building upon our fundamental discovery that stem cells and non-stem cells readily interconvert, we will now incorporate innovative cell systems and the development of our new multi-layered systems biology strategy to elucidate the first comprehensive understanding of the cell biology that underlies cell state changes. These studies are a major step toward understanding the fundamentals of life. Read moreRead less
A molecular timer for inflammation and cell death. This project aims to improve our understanding of the timely function of the immune system. Most processes fundamental to life rely on the timely execution of cellular functions. One biological system in which timing is paramount is the immune system. Organismal health relies upon this front-line defence system for rapidly detecting invading microbes and inducing an appropriate, and timely, antimicrobial response to clear infection. We do not cu ....A molecular timer for inflammation and cell death. This project aims to improve our understanding of the timely function of the immune system. Most processes fundamental to life rely on the timely execution of cellular functions. One biological system in which timing is paramount is the immune system. Organismal health relies upon this front-line defence system for rapidly detecting invading microbes and inducing an appropriate, and timely, antimicrobial response to clear infection. We do not currently understand how immune responses are temporally coordinated. This proposal aims to address this key knowledge gap by characterising a novel molecular timer that dictates the co-ordinated timing of immune responses and immune cell death. These studies may yield fundamental insight into mammalian anti-microbial mechanisms.Read moreRead less
Responsible Urban Innovation with Local Government Artificial Intelligence. Artificial intelligence (AI) is not only becoming an integral part of urban services, but also impacting and shaping the future of cities and societies. However, the current AI practice has shown that urban innovation without responsibility generates more problems than it solves. Especially, the absence of a deep understanding of the costs, benefits, risks and impacts of deploying government AI systems creates negative e ....Responsible Urban Innovation with Local Government Artificial Intelligence. Artificial intelligence (AI) is not only becoming an integral part of urban services, but also impacting and shaping the future of cities and societies. However, the current AI practice has shown that urban innovation without responsibility generates more problems than it solves. Especially, the absence of a deep understanding of the costs, benefits, risks and impacts of deploying government AI systems creates negative externalities and serious concerns in the society. This project will generate new knowledge on the most appropriate approaches for local governments to engage with AI to achieve responsible urban innovation. The project outcomes will include responsible AI adoption and implementation pathways for Australian local governments.Read moreRead less
Enabling Disability? Autonomous Technologies & CaLD persons with disability. Over 1 million disabled Australians are from culturally and linguistically diverse (CaLD) communities, the majority of whom are ineligible for disability and multicultural services. CaLD persons with disability significantly rely on digital information systems, devices and platforms to secure their economic, social and cultural inclusion. Evidence to date documents the continual exclusionary impact of artificial intelli ....Enabling Disability? Autonomous Technologies & CaLD persons with disability. Over 1 million disabled Australians are from culturally and linguistically diverse (CaLD) communities, the majority of whom are ineligible for disability and multicultural services. CaLD persons with disability significantly rely on digital information systems, devices and platforms to secure their economic, social and cultural inclusion. Evidence to date documents the continual exclusionary impact of artificial intelligence (AI) behind such technologies in addition to its inaccessibility to complex end-users. Yet, AI is now central to socio-economic well being and inclusion. In partnership with community and industry, this project will inform future AI developments and policy increasing its adaptability, accessibility and affordability.
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The control of chromosome division during female meiosis. Mammalian eggs are stored life-long and finally mature in the hours before ovulation. This project examines how the chromosomes in the egg are separated properly so as to produce a mature egg capable of being fertilized by a sperm. Often in eggs chromosome division is imprecisely executed, and this project will help us understand why this occurs.
Digital technologies and the private rental sector in Australia. This project aims to show how digital technologies are transforming the private rental sector in Australia. This project expects to generate new knowledge about the growing global reach of digital technologies aimed at private renters, landlords and property managers. The expected outcomes of this project include the production of social scientific knowledge about the potential of digital technologies to be both socially pernicious ....Digital technologies and the private rental sector in Australia. This project aims to show how digital technologies are transforming the private rental sector in Australia. This project expects to generate new knowledge about the growing global reach of digital technologies aimed at private renters, landlords and property managers. The expected outcomes of this project include the production of social scientific knowledge about the potential of digital technologies to be both socially pernicious and socially progressive. This project should provide significant benefits for Australian renters and our tenant advocacy partners who represent them, and to show how digital technologies can be used to create a better housing system.Read moreRead less
Multi-resolution situation recognition for urban-aware smart assistant. This project aims to develop a situation recognition framework to recognise and anticipate unforeseen emerging situations, such as schedule changes, incidents, and disruptions in an urban environment. The project will address a significant knowledge gap by capturing and modelling unpredictability in human mobility and work routines. The outcome will be a situation recognition framework that can be applied at the individual, ....Multi-resolution situation recognition for urban-aware smart assistant. This project aims to develop a situation recognition framework to recognise and anticipate unforeseen emerging situations, such as schedule changes, incidents, and disruptions in an urban environment. The project will address a significant knowledge gap by capturing and modelling unpredictability in human mobility and work routines. The outcome will be a situation recognition framework that can be applied at the individual, social group, and urban level, and at multiple locations and time scales. This should provide users with timely notifications and recommendations to resume their activities and routines. The expected benefits will be far-ranging and adaptable to many domains, from personal smart assistants to trip planning and emergency services.Read moreRead less
Imaging the foundation of the nervous system. This Project aims to understand the formation of the neural tube; a fundamental tissue structure that generates the brain and the spinal cord. Using interdisciplinary approaches and exploiting recent advances in transgenic and imaging technologies, the Project expects to reveal the complex interplay of molecular, cellular and mechanical processes that direct neural tissue formation and cell fate specification. Outcomes from the Project include knowle ....Imaging the foundation of the nervous system. This Project aims to understand the formation of the neural tube; a fundamental tissue structure that generates the brain and the spinal cord. Using interdisciplinary approaches and exploiting recent advances in transgenic and imaging technologies, the Project expects to reveal the complex interplay of molecular, cellular and mechanical processes that direct neural tissue formation and cell fate specification. Outcomes from the Project include knowledge of previously intractable developmental processes, training of future scientists and development of international collaborations. This should provide enhanced imaging capacity, a higher quality scientific workforce and position Australia at the forefront of developmental biology.
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Investigating the impact of augmented reality on consumer decision making and marketing systems. The marketing environment is changing rapidly, with mobile digital devices providing consumers the ability to augment their physical reality with virtual representations. This project investigates how consumers make choices, how manufacturers design successful business practices and how regulators proscribe manipulative behaviour in these environments.