Evolution, disease and extinction - using ancient and modern Deoxyribonucleic acid (DNA) to investigate molecular evolution in the Tasmanian devil. The Tasmanian devil is Australia's largest living marsupial carnivore and one of Tasmania's key tourism icons. Extinction in the wild will have long-term impacts on Tasmanian native ecosystems and economy. This study will provide critical genetic data and tools to monitor and prioritise conservation strategies, including insurance populations and dis ....Evolution, disease and extinction - using ancient and modern Deoxyribonucleic acid (DNA) to investigate molecular evolution in the Tasmanian devil. The Tasmanian devil is Australia's largest living marsupial carnivore and one of Tasmania's key tourism icons. Extinction in the wild will have long-term impacts on Tasmanian native ecosystems and economy. This study will provide critical genetic data and tools to monitor and prioritise conservation strategies, including insurance populations and disease suppression, aimed at preventing extinction. It will strengthen ongoing conservation programs carried out by the Save the Tasmanian Devil Program and will help publicise the plight of the devil both nationally and internationally.Read moreRead less
Developing best-practice approaches for restoring forest ecosystems that are resilient to climate change. Existing restoration practices for forests tend to rely on ad hoc rules of thumb that lack a firm scientific basis and risk failure due to climate change. The project will model biodiversity, genetic and growth performance data to develop best-practice restoration guidelines for forest ecosystems to enable them to become resilient to climate change and maximise biodiversity and carbon captur ....Developing best-practice approaches for restoring forest ecosystems that are resilient to climate change. Existing restoration practices for forests tend to rely on ad hoc rules of thumb that lack a firm scientific basis and risk failure due to climate change. The project will model biodiversity, genetic and growth performance data to develop best-practice restoration guidelines for forest ecosystems to enable them to become resilient to climate change and maximise biodiversity and carbon capture outcomes.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100929
Funder
Australian Research Council
Funding Amount
$462,948.00
Summary
Using ancient DNA to uncover climate change impacts on Antarctica. This project aims to utilise ancient DNA preserved in the seafloor to investigate how past Antarctic marine ecosystems have responded to past climatic changes, with a focus on the Holocene (last ~11,700 years). The study will generate the first-ever picture of marine community changes across the entire marine food web and unravel adaptation mechanisms of key marine organisms to climate shifts. Expected project outcomes will inclu ....Using ancient DNA to uncover climate change impacts on Antarctica. This project aims to utilise ancient DNA preserved in the seafloor to investigate how past Antarctic marine ecosystems have responded to past climatic changes, with a focus on the Holocene (last ~11,700 years). The study will generate the first-ever picture of marine community changes across the entire marine food web and unravel adaptation mechanisms of key marine organisms to climate shifts. Expected project outcomes will include significant knowledge advances into the evolution and resilience of Antarctic ecosystems over geological timescales. This will position Australia at the forefront of marine sedimentary ancient DNA research, and also provide valuable guidance for the conservation of Antarctica during ongoing climate change.Read moreRead less
Ecological-epidemiological models of feral swamp buffalo control in northern Australia. This research is locally, nationally and internationally significant because it 1) improves the capacity of the Northern Territory and its traditional aboriginal owners to manage together this prevalent species in an effort to minimise disturbance to native flora and fauna and to understand the long-term implications of continued proliferation, 2) provides a nationally relevant system to monitor and project t ....Ecological-epidemiological models of feral swamp buffalo control in northern Australia. This research is locally, nationally and internationally significant because it 1) improves the capacity of the Northern Territory and its traditional aboriginal owners to manage together this prevalent species in an effort to minimise disturbance to native flora and fauna and to understand the long-term implications of continued proliferation, 2) provides a nationally relevant system to monitor and project the spread of disease through feral animal populations in Australia, and 3) combines quantitative data and robust analytical tools that can be used as a template for solving many broad-scale feral animal problems around the world.Read moreRead less
Detecting and deciphering extinction dynamics under environmental change. This project aims to improve knowledge of extinction processes and impacts. It will use high-performance computing and museum collections to disentangle the ecological mechanisms that were integral in the initial decline and later extinction of Australia's unique mammals. Its significance is that it will establish the historical ranges and past population trajectories of Australian threatened mammals, pinpointing the combi ....Detecting and deciphering extinction dynamics under environmental change. This project aims to improve knowledge of extinction processes and impacts. It will use high-performance computing and museum collections to disentangle the ecological mechanisms that were integral in the initial decline and later extinction of Australia's unique mammals. Its significance is that it will establish the historical ranges and past population trajectories of Australian threatened mammals, pinpointing the combinations of ecological characteristics and threats that most affect risk of extinction from environmental change. Expected outcomes and benefits are new data and verified models to enrich conservation research and inform evidence-based solutions to better protect and recover some of Australia’s most threatened species.Read moreRead less
Identification And Characterisation Of Novel Genes For Congenital Cataract
Funder
National Health and Medical Research Council
Funding Amount
$432,750.00
Summary
Cataracts are the leading cause of blindness worldwide. The term describes a clouding of the lens which may lead to visual impairment. Congenital cataracts (present at birth) are less common than age-related cataract but the lifelong impact on vision can be severe, with a third of patients remaining legally blind. Late complications such as aphakic glaucoma may be blinding. We have shown that congenital cataracts are often inherited and have performed a population-based study in South-Eastern Au ....Cataracts are the leading cause of blindness worldwide. The term describes a clouding of the lens which may lead to visual impairment. Congenital cataracts (present at birth) are less common than age-related cataract but the lifelong impact on vision can be severe, with a third of patients remaining legally blind. Late complications such as aphakic glaucoma may be blinding. We have shown that congenital cataracts are often inherited and have performed a population-based study in South-Eastern Australia over the past 5 years to determine the causative genes. A large number of families have been involved in the study and solid progress has been made in identifying mutations in cataract genes and understanding what effect these may have on the patient's prognosis. We have recently identified a new gene in a large Australian family with a syndrome of cataract, mental retardation and teeth problems. This syndrome, known as Nance-Horan syndrome was originally described in Australia 30 years ago and we have worked with the original family to find the exact gene responsible. We already know that this gene causes the same syndrome in other families and in this project we will examine whether it can cause cataract without the other features or mental retardation without cataract. We will perform a series of experiments to learn what this gene does and how it causes the disease. We have also selected 3 other very interesting families with congenital cataracts for further study as we either know already or strongly suspect that they will enable us to identify further new genes for cataract, and in one case mental retardation. Our work in other diseases indicates that understanding the genes in severe young onset cases can give valuable clues to the causes of age-related forms and may in the future enable new ways to prevent and treat the commonest cause of worldwide blindness.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100028
Funder
Australian Research Council
Funding Amount
$3,000,000.00
Summary
Australian Membership of the International Ocean Discovery Program. This proposal is for an 18-month membership of the International Ocean Discovery Program (IODP), the world’s largest collaborative research program in Earth and Ocean sciences. The Program studies the history and current activity of the Earth by conducting seagoing coring expeditions and monitoring of instrumented boreholes, using globally unique infrastructure that Australians would otherwise have no access to. Program outcomes ....Australian Membership of the International Ocean Discovery Program. This proposal is for an 18-month membership of the International Ocean Discovery Program (IODP), the world’s largest collaborative research program in Earth and Ocean sciences. The Program studies the history and current activity of the Earth by conducting seagoing coring expeditions and monitoring of instrumented boreholes, using globally unique infrastructure that Australians would otherwise have no access to. Program outcomes include understanding past global environmental change on multiple time scales, the deep biosphere, plate tectonics, formation and distribution of resources, and generation of hazards. These outcomes are paramount to Australia’s national science and research priorities, and societal and economic prosperity.Read moreRead less
Trojan Y as a genetic solution for controlling and eradicating the Eastern mosquitofish, Gambusia holbrooki. The project aims to develop applied genetic strategies to eradicate Gambusia, a serious invasive pest fish species, from a Tasmanian estuary. The goal is to advance the Trojan Y chromosome model from theory to an applied solution. The project aims to employ an integrated ecological, physiological, behavioural, genetic and genomics approach, within the unique island-within-an-island status ....Trojan Y as a genetic solution for controlling and eradicating the Eastern mosquitofish, Gambusia holbrooki. The project aims to develop applied genetic strategies to eradicate Gambusia, a serious invasive pest fish species, from a Tasmanian estuary. The goal is to advance the Trojan Y chromosome model from theory to an applied solution. The project aims to employ an integrated ecological, physiological, behavioural, genetic and genomics approach, within the unique island-within-an-island status of Gambusia infestation in Tasmania.Read moreRead less
A Genome-wide Association Scan To Identify Genetic Risk Factors For Sight Threatening Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$982,203.00
Summary
Diabetic eye disease is an important complication of diabetes that can lead to blindness. Very little is known about how diabetes causes eye disease, but genetics is known to play a role. We aim to identify genes that contribute to eye disease in diabetes patients. We will compare genes between patients with diabetes with and without severe diabetic eye disease using cutting edge genomic technology. We hope to be able to better predict risk of blindness and to move towards novel treatments.