Obstructive Sleep Apnoea As A Risk Factor For Atrial Fibrillation
Funder
National Health and Medical Research Council
Funding Amount
$64,631.00
Summary
Atrial fibrillation is the most common sustained cardiac arrhythmia and obstructive sleep apnoea is a common sleep-related breathing disorder. It has recently been suggested that OSA increases the risk of developing AF . The aim, therefore of this study, is to determine the incidence of sleep apnoea in our population of highly symtomatic patients with atrial fibrillation and to assess the outcome on arrhythmia burden of treatment with continuous positive airways pressure (CPAP).
Optimising Non-invasive Ventilation At Birth For Preterm Infants
Funder
National Health and Medical Research Council
Funding Amount
$735,912.00
Summary
Infants born very premature require respiratory support at birth to make the transition to newborn life. As these infants are very immature and prone to injury, modern respiratory care strategies utilise the least invasive approaches mainly applied using a facemask. However, we have discovered that the larynx is closed at birth and thereby prevents air from entering the lung. This application is focussed on optimising the efficiency of facemask ventilation at birth and stimulating breathing.
A Randomised Controlled Trial Of CPAP Versus Oral Appliance In Obstructive Sleep Apnoea
Funder
National Health and Medical Research Council
Funding Amount
$416,155.00
Summary
Obstructive sleep apnoea (OSA) is a very common disorder, affecting approximately 25% of women and 9% of men in the middle-aged workforce . It is characterised by repetitive, complete or partial closure of the throat passage during sleep, resulting in sleep disturbance and low oxygen levels. When associated with symptoms, termed Obstructive Sleep Apnoea Syndrome, it occurs in 4% of men and 2% of women in middle age. OSA is recognised as a serious public health problem. Continuous Positive Airway ....Obstructive sleep apnoea (OSA) is a very common disorder, affecting approximately 25% of women and 9% of men in the middle-aged workforce . It is characterised by repetitive, complete or partial closure of the throat passage during sleep, resulting in sleep disturbance and low oxygen levels. When associated with symptoms, termed Obstructive Sleep Apnoea Syndrome, it occurs in 4% of men and 2% of women in middle age. OSA is recognised as a serious public health problem. Continuous Positive Airway Pressure is the gold standard treatment, and has been demonstrated to produce major health benefits. However, there is growing evidence supporting the use of oral appliances to treat OSA, which are potentially simpler to use. It is thought that these work by enlarging the throat passage. Recent practice guidelines recommend their use as a first line treatment for mild to moderate OSA. The aim of this project is to directly compare the health benefits achievable with these therapies, taking into account patient compliance and preference, and will assist in the development of protocols for the use of these treatments in clinical practice.Read moreRead less
A Prospective Multicentre Randomized Study To Evaluate The Impact Of OSA Treatment With CPAP On Atrial Electrical And Structural Substrate And On Long Term Maintenance Of Sinus Rhythm Following Catheter Ablation Of Atrial Fibrillation
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Atrial fibrillation(AF) is the commonest heart rhythm disorder causing stroke, heart failure and increased mortality. Similarly, obstructive sleep apnea(OSA) is increasingly recognised as a modern epidemic. Epidemiological data have demonstrated an independent association between the two conditions. We will conduct a prospective multicenter randomized study to evaluate the impact of OSA treatment on: (i)maintenance of sinus rhythm after catheter ablation of AF, (ii)atrial structure and function
Treating Insomnia In Patients With Co-existing Obstructive Sleep Apnea
Funder
National Health and Medical Research Council
Funding Amount
$260,046.00
Summary
Obstructive sleep apnea (OSA) and insomnia commonly coexist in the same patient, and can affect how patients adhere to treatment for their OSA. Insomnia can be effectively treated by a clinical psychologist using a technique known as cognitive behaviour therapy (CBT), but it is currently unclear whether this is effective in patients who also have OSA. This research project will investigate whether treatment of insomnia using CBT in patients who have OSA will improve health outcomes.
Treating Insomnia Co-morbid With Obstructive Sleep Apnoea: A Randomized Controlled Clinical Effectiveness Trial.
Funder
National Health and Medical Research Council
Funding Amount
$600,869.00
Summary
Obstructive Sleep Apnoea (OSA) is a common but serious sleep disorder. Continuous positive airways pressure (CPAP) therapy can be very effective in treating OSA. We have found that many patients with OSA also suffer from insomnia, and this can make it hard for them to begin CPAP therapy and hard for them to stick to it. This trial will examine the effect of treating insomnia concurrently with CPAP, with the expectation that overall treatment outcomes will improve.
Continuous Positive Airway Pressure For Obstructive Sleep Apnoea In Quadriplegia: A Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$307,677.00
Summary
Each year in Australia 260 people sustain a SCI, with over half losing full function in their arms and legs (quadriplegia). In addition to the primary disability, there is a very high rate of Obstructive Sleep Apnoea (OSA). This project is a multi-national randomized controlled trial to treat OSA in acute injury with a nasal mask during sleep. The study will determine if we can help people live better after injury by improving sleep, quality of life, memory and attention.
The Interaction Between Obstructive Sleep Apnea And Cardiovascular Risk Factors On Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,263,050.00
Summary
Cardiovascular (CV) disease and obstructive sleep apnoea (OSA) are common causes of morbidity and mortality. OSA is an independent risk factor for CV disease but little is known about which patients with OSA are likely to develop CV disease, and the interaction between OSA and other CV risk factors. We seek to better understand this interaction by exploring which of 4,100 well characterised patients in the West Australian Sleep Health Study (WASHS) 2005-2010 have developed CV disease.
Breathing Easier: Optimising Non-Invasive Ventilation Of Preterm Infants
Funder
National Health and Medical Research Council
Funding Amount
$266,623.00
Summary
Every year in Australia more than 6000 premature babies need breathing support after birth. My research focuses on improving the application of ‘non-invasive’ breathing supports for premature babies. These therapies can avoid the baby needing to be connected to a mechanical breathing machine, thus reducing the risk of damage to the baby’s fragile lungs. My vision is to better understand the way non-invasive breathing supports work, and to provide world-first evidence for their use.