Our centre combines clinical and laboratory expertise to tackle autoimmune, inflammatory, and immune deficiency diseases. Starting from a genetic discovery platform, we aim to understand precisely how the immune system goes wrong in each individual patient to cause disease. This approach will make diagnoses more accurate and tailor treatment to each patient. The centre's approach should provide a template for the implementation of genomics and personalized medicine into routine clinical practice
Understanding The Pathogenesis And Heterogeneity Of Autoimmunity As Failure Of Multiple Steps
Funder
National Health and Medical Research Council
Funding Amount
$504,023.00
Summary
Autoimmune diseases like diabetes, thyroid disease or rheumatoid arthritis affect around 1 in 15 people in Australia. It is clear that defects in a number of different genetic mechanisms can contribute to the development of autoimmunity. But it is currently not clear how these different mechanisms need to interact to prevent the onset of disease. This grant seeks to understand these interactions and how defects in two or more tolerance mechanisms can lead to autoimmunity.
Reducing environmental footprint by improving phosphorous use efficiency. While modern agriculture relies heavily on the use of phosphorous fertilizers, most of them are not used by plants and lost in runoff, resulting in a massive environmental damage through contamination of waterways (termed eutrophication). This project takes advantage of an untapped resource - a unique collection of Tibetan wild barley genotypes, to reveal key traits that confer superior phosphorus use efficiency in wild ba ....Reducing environmental footprint by improving phosphorous use efficiency. While modern agriculture relies heavily on the use of phosphorous fertilizers, most of them are not used by plants and lost in runoff, resulting in a massive environmental damage through contamination of waterways (termed eutrophication). This project takes advantage of an untapped resource - a unique collection of Tibetan wild barley genotypes, to reveal key traits that confer superior phosphorus use efficiency in wild barley and identify appropriate candidate genes and their position on chromosomes for further incorporating these traits into commercial barley cultivars. This will reduce the environmental footprint of modern agricultural practices on terrestrial and aquatic ecosystems without compromising food security.Read moreRead less
How BANK1 Pathway Defects In B Cells Cause Human Lupus
Funder
National Health and Medical Research Council
Funding Amount
$1,316,839.00
Summary
Autoimmune diseases affect 1 in 20 Australians and are incurable. To find effective therapies, we need to understand the genes that cause disease in humans. We have sequenced the entire genome of patients with an autoimmune disease and found several patients carrry two mutations in genes important for activation of B cells and shown these mutations cause disease. We plan to understand how these genes prevent autoimmunity, and to identify the best treatment for patients with these mutations.
Discovery Early Career Researcher Award - Grant ID: DE120101127
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
An integrated statistical genetics framework for breeding superior wheat varieties. Genetic studies in agriculture are rapidly increasing in size and complexity in pursuit of genes behind desirable traits such as yield and water use efficiency. This project will address the need for efficient statistical methods to analyse genetic data and thus enable production of wheat varieties that will contribute to Australian food security.
Apoptosis And Stem Cells In Cancer Development And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$22,852,198.00
Summary
To improve cancer therapy, we are studying two cancer hallmarks: enhanced cell survival and stem cell-like behaviour. As we discovered, cell death is often blocked in cancer cells. Hence, we are attempting to develop drugs that flip the natural ‘cell death switch’. Stem cells are rare cells that generate entire tissues, as we showed for the breast. Certain cancers may be driven by ‘rogue’ stem cells. If so, eradication of these rare cells within the bulk tumour may require novel therapies.
Characterisation of a major quantitative trait locus on wheat chromosome 3BL responsible for Fusarium crown rot resistance. Fusarium crown rot (FCR) is a serious wheat disease in Australia and worldwide. Our team has identified a major chromosome region controlling this disease. This project is proposing to develop DNA markers for marker assisted breeding, to understand the genetic mechanism of resistance and to identify genes responsible for resistance to the disease.
ARC Centre of Excellence for Translational Photosynthesis. The ARC Centre of Excellence for Translational Photosynthesis seeks to develop and harness advances in photosynthesis research, crop bioengineering, plant phenomics and computational tools to realise increased and sustainable crop yields, opening new routes to achieving the next revolution in plant productivity. It will deliver improved yield by undertaking a continuum of fundamental and applied photosynthesis research and targeting proj ....ARC Centre of Excellence for Translational Photosynthesis. The ARC Centre of Excellence for Translational Photosynthesis seeks to develop and harness advances in photosynthesis research, crop bioengineering, plant phenomics and computational tools to realise increased and sustainable crop yields, opening new routes to achieving the next revolution in plant productivity. It will deliver improved yield by undertaking a continuum of fundamental and applied photosynthesis research and targeting projects with a high probability of producing increased yield. Links with national and international institutions, consortia and breeding companies will enhance the prospects of translating genetic improvements into crops such as wheat, rice and sorghum for improved yield.Read moreRead less
Developing strong restorer-of-fertility genes for hybrid wheat breeding. Hybrid wheat varieties yield 10-15% more than conventional lines but a cost-effective system to produce hybrid seeds on a commercial scale is missing. This project aims to deliver such a system for use in hybrid wheat breeding programmes. The outcome will be ultimately higher wheat yield gains in Australia and worldwide. Higher and more stable yields will contribute to higher food security for the growing human population.
Towards improving the yield of Canola and other Brassicas during drought. One of the major problems faced by world agriculture is drought; this project should improve the yield of Canola during moderate to severe droughts. Significantly, this project includes both "traditional" non-genetically modified (GM) strategies and GM strategies to maximise the market for our drought-tolerant canola both in Australia and overseas.