Discovery Early Career Researcher Award - Grant ID: DE160101470
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Improving poultry health and performance through microbiota manipulations. The project aims to develop methods to modulate microbiota to improve poultry health and productivity and reduce the need for antibiotics. Probiotic administration is currently the only way in agriculture to restore imbalanced intestinal microbiota. Recent research shows that intestinal microbiota resist all new-coming bacteria and remove them from the intestinal environment. The initial inoculum at the time of birth shap ....Improving poultry health and performance through microbiota manipulations. The project aims to develop methods to modulate microbiota to improve poultry health and productivity and reduce the need for antibiotics. Probiotic administration is currently the only way in agriculture to restore imbalanced intestinal microbiota. Recent research shows that intestinal microbiota resist all new-coming bacteria and remove them from the intestinal environment. The initial inoculum at the time of birth shapes the gut microbiota for life and has the strongest influence on development of the immune system. Accordingly, at-hatch administration of proven beneficial strains to poultry is likely to ensure permanent colonisation with beneficial bacteria. This process would improve both the productivity and health of poultry and other agricultural animals.Read moreRead less
Linking immunomodulation and latency in alphaherpesvirus infection. Herpesviruses cause major diseases in humans and all domestic animal species. Latency forms a significant part of the evolutionary success of herpesviruses, by enabling transmission of the virus throughout the lifetime of the host. Our work has shown that an alphaherpesvirus protein can divert the host’s immune response to become more antibody-mediated and less T cell-mediated. This study explores the consequences of this immune ....Linking immunomodulation and latency in alphaherpesvirus infection. Herpesviruses cause major diseases in humans and all domestic animal species. Latency forms a significant part of the evolutionary success of herpesviruses, by enabling transmission of the virus throughout the lifetime of the host. Our work has shown that an alphaherpesvirus protein can divert the host’s immune response to become more antibody-mediated and less T cell-mediated. This study explores the consequences of this immune diversion, and examines whether this reduced T cell response enables the development of latent infections. Disrupting the virus-host balance by alterations to this conserved viral protein will enable novel approaches to controlling these economically significant viruses.Read moreRead less
Nucleolus targeting by negative strand RNA viruses. Negative strand viruses (NSVs) include diverse animal pathogens that represent significant threats to Australian livestock industries and access to export markets. The project aims to investigate the interface formed by NSVs with cellular nucleoli in order to determine roles in viral manipulation of cell biology during infection. This project hopes to address a major gap in knowledge in virology regarding the fundamental biology of NSVs, and is ....Nucleolus targeting by negative strand RNA viruses. Negative strand viruses (NSVs) include diverse animal pathogens that represent significant threats to Australian livestock industries and access to export markets. The project aims to investigate the interface formed by NSVs with cellular nucleoli in order to determine roles in viral manipulation of cell biology during infection. This project hopes to address a major gap in knowledge in virology regarding the fundamental biology of NSVs, and is expected to redefine our understanding of the virus-host interactions formed by these important pathogens. By determining the mechanisms of NSV-nucleolus interaction, the project plans to also provide important information for the development of new vaccines/therapeutics for livestock to combat NSVs that target nucleoli.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100735
Funder
Australian Research Council
Funding Amount
$395,204.00
Summary
Understanding infectious laryngotracheitis virus recombination. This project will study the factors that lead to recombination between strains of infectious laryngotracheitis virus (ILTV) concomitant with increased virulence. In previous studies of ILTV, two new genotypes of virulent field strains were shown to be independent recombinants derived from distinct attenuated ILTV commercial vaccines. These strains became the dominant field viruses responsible for widespread and severe disease outbre ....Understanding infectious laryngotracheitis virus recombination. This project will study the factors that lead to recombination between strains of infectious laryngotracheitis virus (ILTV) concomitant with increased virulence. In previous studies of ILTV, two new genotypes of virulent field strains were shown to be independent recombinants derived from distinct attenuated ILTV commercial vaccines. These strains became the dominant field viruses responsible for widespread and severe disease outbreaks in Australian poultry flocks. This project will enhance understanding of the conditions that led to these deleterious natural recombination events and enable the industry to avoid the emergence of new virulent field strains in the future. Read moreRead less
Development of a live vaccine for gut health in poultry. Development of a live vaccine for gut health in poultry. The project aims to develop a live vaccine against necrotic enteritis, a disease of poultry estimated to cost the global poultry industry $5-6 billion USD/annum. It builds on work that has demonstrated the efficacy of an experimental vaccine. The proven antigen, NetB, will be expressed in live delivery vehicles, including the apicomplexan parasite Eimeria and several bacteria strains ....Development of a live vaccine for gut health in poultry. Development of a live vaccine for gut health in poultry. The project aims to develop a live vaccine against necrotic enteritis, a disease of poultry estimated to cost the global poultry industry $5-6 billion USD/annum. It builds on work that has demonstrated the efficacy of an experimental vaccine. The proven antigen, NetB, will be expressed in live delivery vehicles, including the apicomplexan parasite Eimeria and several bacteria strains particularly suited to use in chickens. Comparative analysis of the different vaccine vehicles will allow evaluation of the relative advantages and disadvantage of the different vehicles for delivery of heterologous vaccine antigens, thus informing the choice of appropriate vectors for this and other vaccine applications.Read moreRead less