Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fu ....Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fundamentally understand the relationship between physical-chemical properties and efficacy. Completion of this project aims to produce potent nanoparticle-based adjuvants underpinned by novel manufacturing technology, to ultimately facilitate the development of more effective and protective vaccines for animals and humans.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100174
Funder
Australian Research Council
Funding Amount
$193,000.00
Summary
Acoustic levitation facility for high pressure multiphase systems research. This project aims to create a specialised acoustic levitation facility that delivers precise control of a suspended particle/droplet/bubble within a high pressure continuous phase, and simultaneous measurement of multiple bulk and interfacial properties. Acoustic levitation enables container-less experiments, offering opportunities for applied engineering and fundamental science. This acoustic levitation system will be i ....Acoustic levitation facility for high pressure multiphase systems research. This project aims to create a specialised acoustic levitation facility that delivers precise control of a suspended particle/droplet/bubble within a high pressure continuous phase, and simultaneous measurement of multiple bulk and interfacial properties. Acoustic levitation enables container-less experiments, offering opportunities for applied engineering and fundamental science. This acoustic levitation system will be integrated with a specialised Raman imaging microscope to study crystallisation, mass transfer and molecular exchange, in application areas including energy transport, carbon capture and storage, and protein nucleation. This project is expected to open new avenues in engineering, chemistry and physics.Read moreRead less
Molecular movies using time-resolved momentum spectroscopies. This project aims to use time-resolved momentum spectroscopies to take snapshots of chemical and physical processes as they evolve in time. This project expects to use these molecular movies to track the changes to electron motion after they have absorbed light. Expected outcomes of this project include understanding how the motion of electrons can drive physical processes and induce chemical changes. This will provide significant ben ....Molecular movies using time-resolved momentum spectroscopies. This project aims to use time-resolved momentum spectroscopies to take snapshots of chemical and physical processes as they evolve in time. This project expects to use these molecular movies to track the changes to electron motion after they have absorbed light. Expected outcomes of this project include understanding how the motion of electrons can drive physical processes and induce chemical changes. This will provide significant benefits through expanding knowledge that will assist in controlling chemical reactions and developing technologies with improved performance, such as sensors and solar cells. Read moreRead less
Organically-Capped Copper Nanowires for Soft Electronic Skin Sensors. Soft skin-like electronics can enable applications that are impossible to achieve with today's rigid circuit board technologies. However, it is difficult to realise such future soft electronics with traditional materials and conventional manufacturing methodologies. This project aims to synthesise novel organically-capped copper nanowires as electronic inks (e-inks) for developing cost-effective, soft, stretchable conductor (e ....Organically-Capped Copper Nanowires for Soft Electronic Skin Sensors. Soft skin-like electronics can enable applications that are impossible to achieve with today's rigid circuit board technologies. However, it is difficult to realise such future soft electronics with traditional materials and conventional manufacturing methodologies. This project aims to synthesise novel organically-capped copper nanowires as electronic inks (e-inks) for developing cost-effective, soft, stretchable conductor (e-skin) sensors, which are wearable for monitoring blood pulses, body motions and hand gestures in real-time and in situ. This is expected to advance our knowledge in nanotechnology and generate patentable technologies in soft e-skin sensors, and to bring significant scientific and economic gains to Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101788
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Shape sorting of nanoparticles at oil-water interfaces in microchannels. This project aims to study the effect of shape on the adsorption of nanoparticles at an oil/water interface and develop a rapid, inexpensive, efficient, versatile method for shape sorting of nanoparticles using a microfluidic approach. This technique can be applied for fractionation of synthetic nanoparticles, biosample analysis and environmental monitoring.
Development of functional dendrimer-like inorganic nanomaterials with hierarchical pores for biological applications. This project aims to engineer a series of brand new dendrimer-like mesoporous silica nanoparticles with hierarchical pore structure and favourable surface functionality as nanocarriers to construct a smart delivery system. Unique materials structure and surface functionalisation design can endow the system with advanced characteristics of the co-loading of different therapeutic a ....Development of functional dendrimer-like inorganic nanomaterials with hierarchical pores for biological applications. This project aims to engineer a series of brand new dendrimer-like mesoporous silica nanoparticles with hierarchical pore structure and favourable surface functionality as nanocarriers to construct a smart delivery system. Unique materials structure and surface functionalisation design can endow the system with advanced characteristics of the co-loading of different therapeutic agents and the highly efficient target delivery that are not readily obtainable using other organic or inorganic materials. The proposed delivery systems are of great importance for improving the therapeutic efficiency of complex diseases, and in general, for expanding human’s life span.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100021
Funder
Australian Research Council
Funding Amount
$370,000.00
Summary
Orchestrating cellular processes by engineering silicon nanowire architectures. This project aims to improve gene transport by creating low-cost, easily implemented, programmable and controllable silicon nanowire-mediated transfection technology, and to demonstrate high-throughput, parallel trafficking of bioactive payloads. Success would enable the design and fabrication of nano–bio interfaces with closely controlled geometry and architecture, to orchestrate specific cellular processes such as ....Orchestrating cellular processes by engineering silicon nanowire architectures. This project aims to improve gene transport by creating low-cost, easily implemented, programmable and controllable silicon nanowire-mediated transfection technology, and to demonstrate high-throughput, parallel trafficking of bioactive payloads. Success would enable the design and fabrication of nano–bio interfaces with closely controlled geometry and architecture, to orchestrate specific cellular processes such as cellular reprogramming, adhesion, morphology, and differentiation with unprecedented efficiency and predictability. The advance could lead to breakthroughs in fundamental cellular studies, and better understanding of cell behaviour, function and fate.Read moreRead less
Forensic platform technologies for roadside and workplace testing based on nanostructured silicon chips. Roadside drug testing has recently been incorporated into government legislation throughout Australia and abroad. The objective of this project is to develop advanced analysis technologies for implementing effective roadside and workplace testing. The availability of these technologies will increase the safety of Australian drivers and workers.
Printable technologies for high security documents and consumer products. Printable technologies for high security documents and consumer products. This project aims to develop two next-generation printable security feature technologies to protect users from counterfeiting, which costs the world economy billions in lost revenue and undermines the security of citizens. First, it aims to enhance the security of banknotes by developing printable active device patches with energy harvesting flexible ....Printable technologies for high security documents and consumer products. Printable technologies for high security documents and consumer products. This project aims to develop two next-generation printable security feature technologies to protect users from counterfeiting, which costs the world economy billions in lost revenue and undermines the security of citizens. First, it aims to enhance the security of banknotes by developing printable active device patches with energy harvesting flexible polymers as a power source and thin film graphene/polymer nanomaterial as an electrode/energy storage media. Second, it aims to design invisible carbon nanotube inks for optical authentication via near infrared activation. Both technologies are expected to thwart sophisticated counterfeits, particularly those supported by organised crime.Read moreRead less
Self-assembling nanoporous graphene with dialable pore sizes for green energy production. The biggest barrier to the Sun being our main energy source is it is not always available. This can be overcome by having an economical means of storing solar energy as it is produced. This project will demonstrate such a technology by using nanoporous graphene to support artificial photosynthesis to produce fuel from water and carbon dioxide using sunlight.