Improved Formulations Of Anti-cancer Agents 5-Fluorouracil And Oxaliplatin Using Excipient Technology
Funder
National Health and Medical Research Council
Funding Amount
$202,973.00
Summary
Chemotherapy plays a key role in cancer treatment, however, problems persist with severe adverse toxic effects. Combinations of anti-cancer agents give better results, but these agents still have major negative effects, for example, on veins and peripheral nerves and they must be given separately. We have developed a novel, all-in-one formulation of Oxaliplatin with 5-Fluorouracil and Leucovorin, with the potential for fewer toxic effects and improved patient care.
Enhancing Hypnotic Responding with Oxytocin. Although hypnosis has been studied for over a 100 years, little is understood about the neuroscience of hypnosis. This project represents the first investigation of the neural mechanisms underpinning hypnosis. At an applied level, this project has the potential to markedly increase the capacity for Australians to benefit from medical and psychological hypnosis. Hypnosis has been shown to assist in many medical and psychological conditions, and by d ....Enhancing Hypnotic Responding with Oxytocin. Although hypnosis has been studied for over a 100 years, little is understood about the neuroscience of hypnosis. This project represents the first investigation of the neural mechanisms underpinning hypnosis. At an applied level, this project has the potential to markedly increase the capacity for Australians to benefit from medical and psychological hypnosis. Hypnosis has been shown to assist in many medical and psychological conditions, and by developing the means to increase hypnotic responding, this project can directly enhance the physical and psychological health of Australians.Read moreRead less
Antagonist Of Corticotrophin Releasing Hormone As Therapeutic Agents For The Prevention Of Premature Birth In Humans
Funder
National Health and Medical Research Council
Funding Amount
$376,650.00
Summary
In developed countries the most common cause of the death of a newborn baby is premature delivery. Pre-term delivery remains the greatest cause of neonatal mortality in the western world and a major consumer of health dollars (approx. $5-7B per year in the US alone). However, a delay in the onset of labour from 20 to 25 weeks has been shown to result in a 55% greater probability of infant survival (550 fewer deaths per 1000). This project will allow: The development of new drugs that will allow ....In developed countries the most common cause of the death of a newborn baby is premature delivery. Pre-term delivery remains the greatest cause of neonatal mortality in the western world and a major consumer of health dollars (approx. $5-7B per year in the US alone). However, a delay in the onset of labour from 20 to 25 weeks has been shown to result in a 55% greater probability of infant survival (550 fewer deaths per 1000). This project will allow: The development of new drugs that will allow the extension of pregnancy term The development of protocols that will in turn reduce neonatal mortality. Additionally we believe that these new agents will be useful in preventing the onset of labour after fetal surgery. Currently there are no effective treatments capable of substantially changing delivery dates. Available therapeutics delay the onset of labour, at best, 24 hours. However, recent exciting results from our laboratories show that rising concentrations of the placental peptide Corticotrophin Releasing Hormone (CRH) are associated with the onset of labour. Further, we have also delayed the onset of labour in pregnant sheep by infusing a relatively insoluble CRH antagonist into the sheep fetus. Labour commenced ONLY AFTER the drug was withdrawn from the mother. This project builds upon an interdisciplinary team: medicinal chemists, molecular modellers, pharmacologists and endocrinologists, to further develop an exciting Australian discovery. Successful completeion of this research will, for the first time, allow the control of pregnancy duration MAXIMISING the benefits to mother and child, reducing mortality and later life morbidities typically associated with premature birth.Read moreRead less
The Intrarenal Renin Angiotensin System (RAS) In Indigenous Women: An Early Indicator Of Renal Dysfunction In Women At Risk Of Pregnancy Complications
Funder
National Health and Medical Research Council
Funding Amount
$645,358.00
Summary
Indigenous women are twice as likely to have low birth weight babies compared to non-Indigenous women and 2.5 times as likely to develop preeclampsia, possibly because they have a much greater incidence of chronic kidney disease, predisposing them to these pregnancy outcomes. We have found a new, sensitive marker of early stage renal dysfunction in pregnancy that could be useful for detecting early stage renal disease and which is indicative of an increased risk of adverse pregnancy outcome.
The Power of Causal Attributions: Genetic Essentialist Biases and Health. Great advancements in the science of genetics are accompanied by increased public propensity to attribute causality to the genes for diverse outcomes such as abilities, social group differences, attitudes, and diseases. These genetic attributions activate cognitive biases termed Genetic Essentialist Biases, which have been shown to instigate a variety of deleterious outcomes. The project will evaluate hypothesized detrimen ....The Power of Causal Attributions: Genetic Essentialist Biases and Health. Great advancements in the science of genetics are accompanied by increased public propensity to attribute causality to the genes for diverse outcomes such as abilities, social group differences, attitudes, and diseases. These genetic attributions activate cognitive biases termed Genetic Essentialist Biases, which have been shown to instigate a variety of deleterious outcomes. The project will evaluate hypothesized detrimental effects of genetic attributions on actual health behaviours, endorsement of health policies, and disease related stigma. Furthermore, it will test interventions designed to reduce the negative effects of such attributions on attitudes, beliefs, intentions, and behaviours related to a common disease. Read moreRead less
Australian Laureate Fellowships - Grant ID: FL150100096
Funder
Australian Research Council
Funding Amount
$3,030,714.00
Summary
Development of emotional functioning during adolescence. Development of emotional functioning during adolescence: This fellowship project aims to understand factors that increase risk and provide protection from the development of emotional distress during the adolescent years. Adolescence is a critical stage in the development of emotional functioning, and behaviours developed at this time can influence the entire life course. The research plans to follow a large group of teenagers over many ye ....Development of emotional functioning during adolescence. Development of emotional functioning during adolescence: This fellowship project aims to understand factors that increase risk and provide protection from the development of emotional distress during the adolescent years. Adolescence is a critical stage in the development of emotional functioning, and behaviours developed at this time can influence the entire life course. The research plans to follow a large group of teenagers over many years and will focus on risk and protective factors that are open to possible modification. The intended outcomes seek to support the development of prevention and promotion programs and public health initiatives to maximise positive emotional development in young people. It is hoped that these will lead to increased productivity and better quality of life.Read moreRead less
Moving Behavioural Neuroscience & Neuroeconomics Into Dementia Prevention: Spatial Tracking And Economic Decision-making As New Sensitive Measures Of Daily Function
Funder
National Health and Medical Research Council
Funding Amount
$595,588.00
Summary
This project will aim to develop new measures for clinical trials by learning the relationship between older people's movements around the house, ability to make decisions about their health and finance and their cognitive performance. These instruments may aid future trials of drugs and other interventions for preventing dementia by indicating how basic behavioural patterns respond to interventions.
Australian Resuscitation Outcomes Consortium [AUS-ROC] CRE
Funder
National Health and Medical Research Council
Funding Amount
$2,668,571.00
Summary
The Australian Resuscitation Outcomes Consortium (Aus-ROC) will be modelled on the highly successful North American Resuscitation Outcomes Consortium. The mission of Aus-ROC will be to conduct clinical trials and observational studies into the emergency management of out-of-hospital cardiopulmonary arrest. Building on our existing collaborative partnerships, our goal is to improve patient outcomes and build the research capacity in prehospital emergency care.
There is increased recognition that sleep health problems are a major cause of illness in the community. These include disorders such as obstructive sleep apnoea, insomnia, restless legs syndrome and health problems related to shift work. It is proposed to form a consolidated network of sleep investigation groups to undertake larger scale clinical trials aimed at deciding what are the best treatments for different sleep disorders. The enabling grant will provide resources that will make Australi ....There is increased recognition that sleep health problems are a major cause of illness in the community. These include disorders such as obstructive sleep apnoea, insomnia, restless legs syndrome and health problems related to shift work. It is proposed to form a consolidated network of sleep investigation groups to undertake larger scale clinical trials aimed at deciding what are the best treatments for different sleep disorders. The enabling grant will provide resources that will make Australian involvement in international studies more competitive and achieve higher publication quality for the research work.Read moreRead less
Reducing Deaths From Pesticide Poisoning - Establishing A Regional Toxicology Research Centre.
Funder
National Health and Medical Research Council
Funding Amount
$739,727.00
Summary
The World Health Organization estimates suggest nearly half a million people die from acute pesticide poisoning in the Asia-Pacific region each year. The Sri Lankan project will be the first attempt to systematically test whether a range of strategies can reduce long-term neurological damage and deaths from pesticides. The Australian-Sri Lankan Collaboration will, over the next five years, aim to improve assessment of sub-acute and long-term morbidity; promote 'evidence-based' treatment; develop ....The World Health Organization estimates suggest nearly half a million people die from acute pesticide poisoning in the Asia-Pacific region each year. The Sri Lankan project will be the first attempt to systematically test whether a range of strategies can reduce long-term neurological damage and deaths from pesticides. The Australian-Sri Lankan Collaboration will, over the next five years, aim to improve assessment of sub-acute and long-term morbidity; promote 'evidence-based' treatment; develop new antidotes (and assess their cost effectiveness), and see if pesticide regulation can reduce the rate of severe or fatal poisoning. If successful, this program may become a model for the region as to how to substantially reduce this largely hidden tragedy.Read moreRead less