Inflammatory Pathways For Novel Therapeutic Interventions In Preterm Delivery
Funder
National Health and Medical Research Council
Funding Amount
$568,006.00
Summary
Preterm birth is common and carries severe risks for the child. Existing therapies are not very successful in arresting preterm labour or improving outcomes for the fetus. We have discovered that blocking inflammatory ‘sensor’ molecules can slow labour progression. This project will (1) increase our knowledge of the inflammatory pathways that initiate early labour, and (2) define the mechanism of action and safety of a new drug that has potential for delaying preterm birth in women.
Social exclusion in adolescence: risks, assets, experiences and policy action. This project aims to investigate social exclusion among young people aged 8 to 17 including the risks of exclusion they face, the assets mobilised to support their inclusion and their life experiences in the context of these risks and assets. The project intends to investigate which risks, assets and experiences are most closely related to outcomes, and how these vary by age and gender. Expected outcomes include a new ....Social exclusion in adolescence: risks, assets, experiences and policy action. This project aims to investigate social exclusion among young people aged 8 to 17 including the risks of exclusion they face, the assets mobilised to support their inclusion and their life experiences in the context of these risks and assets. The project intends to investigate which risks, assets and experiences are most closely related to outcomes, and how these vary by age and gender. Expected outcomes include a new understanding of the relationship between social exclusion and outcomes in adolescence as well as entry points for policy intervention. Addressing social exclusion in adolescence will lead to improved outcomes in health, education and productivity, and a more socially-cohesive society.Read moreRead less
The Kids in Communities Study: national investigation of community level effects on children's developmental outcomes. This project (a cross-disciplinary collaboration) will investigate community level factors influencing early childhood developmental outcomes using a mixed methods approach in up to 10 communities across Australia. This will result in a potential set of measures or indicators that reflect communities that are good for children.
Parent involvement goes online: New ecologies of school-home relations. This project aims to: identify forms of digital exclusion and inclusion impacting on parents’ ability to support their children’s education; produce a new conceptual model of technologically mediated school-home relationships; and provide a comprehensive map of school-home connected digital tools and services. Combining a detailed survey of 500 school leaders with innovative networked case studies across three schools and 18 ....Parent involvement goes online: New ecologies of school-home relations. This project aims to: identify forms of digital exclusion and inclusion impacting on parents’ ability to support their children’s education; produce a new conceptual model of technologically mediated school-home relationships; and provide a comprehensive map of school-home connected digital tools and services. Combining a detailed survey of 500 school leaders with innovative networked case studies across three schools and 18 families, this will be the first national study to comprehensively describe and analyse home-school partnerships in the digital age. It will provide policy and educational leadership with a roadmap for addressing barriers to digital inclusion, as schools advance their integration of digital platforms. Read moreRead less
Investigating The Role Of The UPF3B Gene And Nonsense Mediated RNA Decay (NMD) Process In Mental Retardation.
Funder
National Health and Medical Research Council
Funding Amount
$572,710.00
Summary
Intellectual disability is a frequent and important medical problem. Genetic and environmental factors contribute about equally to the aetiology of intellectual disability. Estimated 1-3% of population suffer from a form of intellectual disability. Among the genetic factors contributing to intellectual disability are genes, and their mutations, on one of the human chromosomes, chromosome X. We have been studying human X-chromosome genes for many years and discovered in excess of 20 novel genes c ....Intellectual disability is a frequent and important medical problem. Genetic and environmental factors contribute about equally to the aetiology of intellectual disability. Estimated 1-3% of population suffer from a form of intellectual disability. Among the genetic factors contributing to intellectual disability are genes, and their mutations, on one of the human chromosomes, chromosome X. We have been studying human X-chromosome genes for many years and discovered in excess of 20 novel genes causing various forms of intellectual disability. Surprisingly the number of genes, in which mutations cause various forms of intellectual disability is unexpectedly high. Just on the human X-chromosome we expect in excess of 200 such genes, which is nearly 30% of the gene content of this chromosome. We propose to study a novel gene, UPF3B, we recently identified to be mutated in a form of intellectual disability. The normal function of this gene and its protein is known to a certain extent. The UPF3B protein plays a role of a guardian of other genes in human (and also other species) cells. The role of the UPF3B protein is to prevent erroneous genetic information to be used for the building of proteins with potentially toxic effects to the organism. In our patients this process clearly malfunctions as a consequence of the damaged UPF3B gene. We propose to shed some more light in to the molecular intricacies of this process with the aim to better understand the mechanics of the process. Families, which participate in our studies and have this gene involved will benefit from the availability of direct test. Multiple other families around the world are also likely to benefit, now or in the future.Read moreRead less
Settlement outcomes of Syrian-conflict refugee families in Australia. This project aims to focus on the policy responses to, and settlement outcomes for, Syrian-conflict refugee families in Australia with an emphasis on employment and education. The Syrian conflict has generated an unprecedented flow of refugees across Europe and other countries, including Australia. These countries face new challenges in providing successful settlement outcomes for the refugees. Utilising a longitudinal study o ....Settlement outcomes of Syrian-conflict refugee families in Australia. This project aims to focus on the policy responses to, and settlement outcomes for, Syrian-conflict refugee families in Australia with an emphasis on employment and education. The Syrian conflict has generated an unprecedented flow of refugees across Europe and other countries, including Australia. These countries face new challenges in providing successful settlement outcomes for the refugees. Utilising a longitudinal study of 250 refugee families and fieldwork in key areas of high refugee settlement in NSW, Victoria and Queensland, this project will generate comparative insights to identify policy and program responses that lead to the most successful settlement outcomes. Improved employment, education and settlement outcomes for refugees will have economic, social and cultural benefits for Australian society and improve the quality of life of refugees.Read moreRead less
Transport risk pathways for emerging invasive species. Our Australian economy depends on tourism and trade and this carries unavoidable risks for the introduction and establishment of new invasive pests and diseases. This project will build datasets from four real-world problem agenda in global invasion biology. Informed by these data, this project will develop and apply state-of-the-art mathematical transport models to predict the risks and frequency of future biological invasion events. The pr ....Transport risk pathways for emerging invasive species. Our Australian economy depends on tourism and trade and this carries unavoidable risks for the introduction and establishment of new invasive pests and diseases. This project will build datasets from four real-world problem agenda in global invasion biology. Informed by these data, this project will develop and apply state-of-the-art mathematical transport models to predict the risks and frequency of future biological invasion events. The project will contribute directly to safeguarding Australia from invasive pests and diseases.Read moreRead less
Producing, managing and owning knowledge in the 21st century university. The use, creation and dissemination of the products of research is a core function of Australian universities, and critical if research is to have impact in the real world. It is regulated by intellectual property laws, sector-wide grant conditions, licensing agreements with libraries and university policies on intellectual property ownership, authorship, open access and engagement. International law and practice creates an ....Producing, managing and owning knowledge in the 21st century university. The use, creation and dissemination of the products of research is a core function of Australian universities, and critical if research is to have impact in the real world. It is regulated by intellectual property laws, sector-wide grant conditions, licensing agreements with libraries and university policies on intellectual property ownership, authorship, open access and engagement. International law and practice creates another layer of regulation. Navigating this terrain is the responsibility of every academic and manager, but it is a complex, incoherent framework. Mapping it with an eye toward harmonization and coherence will better advance public goals, in particular improve access to research for impact and engagement.Read moreRead less
Culturally Responsive Schooling. Australian schools are struggling to respond positively to the increasing cultural diversity of the student cohort. The aim of this study is to research how schools become culturally responsive and specifically explores how the affective environments of schools attend to the diverse cultural, academic and emotional needs of their communities. This this study brings together methods borrowed from educational ethnography, critical policy analysis, and educational ....Culturally Responsive Schooling. Australian schools are struggling to respond positively to the increasing cultural diversity of the student cohort. The aim of this study is to research how schools become culturally responsive and specifically explores how the affective environments of schools attend to the diverse cultural, academic and emotional needs of their communities. This this study brings together methods borrowed from educational ethnography, critical policy analysis, and educational action research. The study will inform curriculum and pedagogical reform in schools, changes to teacher education programs, and potentially ameliorate systemic inequality in Australian schooling. Read moreRead less
Keeping the best: how school leaders engage and retain high quality early career teachers. This project will investigate how school leaders use micropolitical strategies to engage and retain high quality early career teachers. It will develop a framework for school leaders to guide policies and practices to keep the best early career teachers in the profession.