Computational enzymology: exploring the free energy landscape of enzymatic catalysis. Most biochemical reactions depend on enzyme catalysis and understanding how enzymes work at the molecular level remains a central question. This project will develop a suite of computational models to study the mechanisms of enzyme-catalysed reactions and such knowledge holds promise for technological benefits in the form of new drugs and novel catalysts.
Structural and functional chacterisation of Acot7 in macrophages and its role in inflammation. This project will develop better understanding of the cellular pathways that mediate inflammation and will provide detailed information on a specific enzyme that produces arachidonic acid, the precursor to many inflammatory molecules, and characterisation of novel inhibitory binding sites.
A new approach to quantitative interpretation of paleoclimate archives. Skeletons of marine organisms can be used to reconstruct past climates and make predictions for the future. The precondition is the knowledge of how climatic and environmental information is incorporated into the biominerals. This project will use cutting-edge nano-analytical methods to further our understanding of how organisms build their skeletons.
The mechanical and electrical behaviour of boron nitride nanotubes: Insight from in-situ transmission electron microscopy investigation. Boron nitride nanotubes are an emerging class of inorganic nanotubes with insulating property, exceptional thermal stability, high thermal conductivity, and superior mechanical properties including ultrahigh strength and elastic modulus which are not possible in conventional materials. This project aims to apply state-of-the-art in-situ transmission electron mi ....The mechanical and electrical behaviour of boron nitride nanotubes: Insight from in-situ transmission electron microscopy investigation. Boron nitride nanotubes are an emerging class of inorganic nanotubes with insulating property, exceptional thermal stability, high thermal conductivity, and superior mechanical properties including ultrahigh strength and elastic modulus which are not possible in conventional materials. This project aims to apply state-of-the-art in-situ transmission electron microscopy techniques to explore the dependence of mechanical properties on size, morphology and structure of boron nitride nanotubes and the effect of mechanical strain on electrical properties, which will provide opportunities for composite materials reinforcement via nanotubes, and tune the electronic and optoelectronic properties of nanotubes via strain engineering.Read moreRead less
Mechanics of micro/nanoscale multilayers: theories and applications. The purpose of the project is to develop novel theoretical models, advanced numerical techniques and guidelines for the design and application of micro/nanoscale multilayers. The expected outcomes are fundamental contributions to the knowledge base of micro/nanoscale multilayered materials which are increasingly used in micro/nanotechnology.
Cell division in archaea. This project aims to reveal how archaeal FtsZ proteins and their spatial regulators control cell division, and develop an archaeal paradigm for cell biology. Archaea, a major group of microorganisms, are one of the three major domains of life on earth. They are diverse and show potential for innovation, but, owing to their relatively recent identification, are poorly understood compared to bacteria and eukaryotes. Expected outcomes are insights into the function of FtsZ ....Cell division in archaea. This project aims to reveal how archaeal FtsZ proteins and their spatial regulators control cell division, and develop an archaeal paradigm for cell biology. Archaea, a major group of microorganisms, are one of the three major domains of life on earth. They are diverse and show potential for innovation, but, owing to their relatively recent identification, are poorly understood compared to bacteria and eukaryotes. Expected outcomes are insights into the function of FtsZ-based cell division in archaea; better understanding of cell structure, function and diversity; and a wide range of cell and molecular biology studies.Read moreRead less
The effect of structure and size on the mechanical behaviour of III-V semiconductor nanowires. The project aims to apply in-situ deformation transmission electron microscopy to investigate the mechanical behaviour of compound semiconductor nanowires and the effect of structure and geometry on the behaviour. The results will uncover the fundamental mechanical properties of nanowires and will guide the design of nanowire-based devices.
From Snowball Earth to Animals: the Influence of Mantle Dynamics. This project aims to investigate how solid Earth processes contributed to ‘Snowball Earth’ events around 700 million years ago and to the explosion of complex life 540 million years ago, which will shed light on our origin as a species. The approach consists of merging cutting-edge models of the plate-mantle system with the global rock record. The intended outcome is to understand relationships between mantle convection, the behav ....From Snowball Earth to Animals: the Influence of Mantle Dynamics. This project aims to investigate how solid Earth processes contributed to ‘Snowball Earth’ events around 700 million years ago and to the explosion of complex life 540 million years ago, which will shed light on our origin as a species. The approach consists of merging cutting-edge models of the plate-mantle system with the global rock record. The intended outcome is to understand relationships between mantle convection, the behaviour of the magnetic field, global sea levels, continental-scale topography, and the composition of the ocean and atmosphere. Expected significant benefits include building capacity in Earth Sciences and the development of new models that can be used to explore the mineral endowment of the Australian crust.Read moreRead less
Elucidating the molecular mechanisms of dual function transporter/channels. This project aims to understand how a membrane protein that transports chemical messengers in the brain functions and how it is influenced by the membrane in which it is embedded. Cells from all life forms have a lipid membrane that separates them from their external environment. These membranes contain proteins that control the movements of molecules into and out of cells and are vital for a plethora of physiological pr ....Elucidating the molecular mechanisms of dual function transporter/channels. This project aims to understand how a membrane protein that transports chemical messengers in the brain functions and how it is influenced by the membrane in which it is embedded. Cells from all life forms have a lipid membrane that separates them from their external environment. These membranes contain proteins that control the movements of molecules into and out of cells and are vital for a plethora of physiological processes including cell-to-cell communication. The outcomes of this study will include new knowledge of this process and chemical modifiers of this transport protein. This project will benefit structural biology and biophysics training and may lead to the development of novel compounds that can be used to explore function. Read moreRead less
Sustainable wastewater management. This project aims to extract high-value liquid products (medium-chain fatty acids) from wastewater with minimised greenhouse gas emissions and energy consumption, in addition to clean water. Traditional wastewater treatment removes organic carbon and nutrients by using vast amounts of energy and releasing greenhouse gas. However, wastewater is a substantial but largely untapped renewable resource. The intended outcome is to transform wastewater from a troubleso ....Sustainable wastewater management. This project aims to extract high-value liquid products (medium-chain fatty acids) from wastewater with minimised greenhouse gas emissions and energy consumption, in addition to clean water. Traditional wastewater treatment removes organic carbon and nutrients by using vast amounts of energy and releasing greenhouse gas. However, wastewater is a substantial but largely untapped renewable resource. The intended outcome is to transform wastewater from a troublesome pollutant to a valuable resource and reduce carbon footprints.Read moreRead less