Biomarkers In Barrett's Oesophagus And Oesophageal Adenocarcinoma
Funder
National Health and Medical Research Council
Funding Amount
$67,690.00
Summary
Barrett’s oesophagus (BO) is a condition in which the normal lining of the lower oesophagus is replaced with intestine-like tissue as a response to long-standing acid reflux. BO can progress to oesophageal adenocarcinoma (OAC), an aggressive cancer with poor 5-year survival rates of ~15%. This project aims at detecting genetic and molecular changes that occur in both BO and OAC and which may help predict the risk of progression as well as survival for patients affected by this disease entity.
Validation Of A Multiplexed Blood Based Screening Assay For The Diagnosis Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$556,712.00
Summary
Colorectal cancer (CRC) is the second most common cancer in Australia with poor patient outcome due to late detection of the disease. We have developed a simple blood based test that can diagnose individuals with CRC at an early stage when the chance of cure is greater than 80%.
Development Of A Blood-based Screening Test For Colorectal Neoplasia; Biomarker Expression In Circulating Tumor Cells And Tumor-derived Microvesicles
Funder
National Health and Medical Research Council
Funding Amount
$513,938.00
Summary
A blood-based test for bowel cancer and the premalignant lesion (i.e. adenomas) has potential to improve several aspects of screening for bowel cancer – improved capacity to detect lesions in well people who do not suspect their presence, avoidance of faecal sampling and fewer false-positive results. There is no reliable simple screening test for adenomas. This study aims at developing a practical blood test based on a device that filters and enriches cells from blood that carry these markers