The vision we rely on every day to read and recognise faces depends upon the health of the central portion of our retina, the macula. Age-related Macular Degeneration (AMD) is the leading cause of blindness in Australia and the western world. Researchers at the Australian National University are collaborating to bring a new test for AMD severity to the market within 3 years. The objective is to provide doctors with a rapid, cost-effective tool to help them manage treatment.
Validation Of A Multiplexed Blood Based Screening Assay For The Diagnosis Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$556,712.00
Summary
Colorectal cancer (CRC) is the second most common cancer in Australia with poor patient outcome due to late detection of the disease. We have developed a simple blood based test that can diagnose individuals with CRC at an early stage when the chance of cure is greater than 80%.
Uncovering The Basis Of Inflammatory And Immunodeficiency Diseases
Funder
National Health and Medical Research Council
Funding Amount
$15,718,075.00
Summary
A world-class team from 3 institutions, spanning disciplines of clinical and experimental immunology, therapeutics, signalling and genetics, will identify how immune and inflammatory responses are controlled in both health and disease. The major outcomes of this work will be the generation of new knowledge, concepts and approaches to diagnose, prevent and treat the major human health problems of autoimmune diseases, inflammation, allergy and immunodeficiency.
The Role And Inheritance Of Constitutional Epimutations In Early-onset Colorectal Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$347,551.00
Summary
Traditionally familial cancers are thought to be caused by spelling mistakes within the genetic code of cancer prevention genes. Our group has found that chemical attachments to one gene (MLH1) stops it working, even where there is no spelling mistake, and that those chemical changes can be inherited in families with bowel cancer. We will determine how frequently this type of defect occurs in bowel cancer patients, how and why it arises, and if other cancer genes are similarly affected.
Beyond Scenarios: Testable Models of the Evolution of Norms. The aim of this project is to investigate the evolution of social norms, and their causal role in social life and its breakdown. It expects to generate new knowledge in this area through the application of new formal techniques to existing hypotheses; especially causal analysis, evolutionary game theory, and phylogenetic cross-cultural testing for empirically plausibility. Expected outcomes include theory development, improved research ....Beyond Scenarios: Testable Models of the Evolution of Norms. The aim of this project is to investigate the evolution of social norms, and their causal role in social life and its breakdown. It expects to generate new knowledge in this area through the application of new formal techniques to existing hypotheses; especially causal analysis, evolutionary game theory, and phylogenetic cross-cultural testing for empirically plausibility. Expected outcomes include theory development, improved research infrastructure and training in collaboration with international partners, and theoretical recommendations for policy intervention. This should allow greater insight and control over the levers of peaceful social life, both in traditional societies, and in large, open, multi-cultural nations like Australia. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101770
Funder
Australian Research Council
Funding Amount
$327,841.00
Summary
Secularism and Philosophy: The Challenge of Spinozism. With the resurgence of religious conflict throughout the world, the question of secularism has acquired renewed importance. Nowhere has the plausibility of a secular worldview been more rigorously debated than within the history of philosophy, and no philosopher has aroused more controversy on this subject than Benedict de Spinoza (1632-1677). This project will result in the first history of Spinozism's pivotal role in the history of secular ....Secularism and Philosophy: The Challenge of Spinozism. With the resurgence of religious conflict throughout the world, the question of secularism has acquired renewed importance. Nowhere has the plausibility of a secular worldview been more rigorously debated than within the history of philosophy, and no philosopher has aroused more controversy on this subject than Benedict de Spinoza (1632-1677). This project will result in the first history of Spinozism's pivotal role in the history of secularism, focusing on three distinct episodes of philosophical conflict generated by Spinoza's thought from the late eighteenth century to the present. The study will make clear that secularism is not simply a social and political phenomenon, but a philosophical conundrum, thus far irresolvable.Read moreRead less
The Indian Roots of Modern Chinese Thought. The Project will strengthen Australia's capacity to interpret and engage with our regional and global environments by demonstrating the need for greater understanding of the nationalistic appeal that Yogâcâra thought has held for Chinese intellectuals; and the rise of New Confucianism as a philosophical movement associated with robust expressions of cultural nationalism. It will also further enhance Australia's international intellectual profile by bri ....The Indian Roots of Modern Chinese Thought. The Project will strengthen Australia's capacity to interpret and engage with our regional and global environments by demonstrating the need for greater understanding of the nationalistic appeal that Yogâcâra thought has held for Chinese intellectuals; and the rise of New Confucianism as a philosophical movement associated with robust expressions of cultural nationalism. It will also further enhance Australia's international intellectual profile by bringing together leading researchers to forge innovative research networks and methodologies to advance the knowledge bases of Chinese intellectual history, Chinese Philosophy and Buddhist Studies, and contribute to building Australian research capacity in these three key areas.Read moreRead less
Changing your mind by changing your brain: An interventionist perspective on cognitive neuroscience. Functional neuroimaging provides a tremendous amount of information about the brain, but what it shows about the mind is less clear. Addressing this fundamental philosophical question requires developing a detailed account of theory-testing in cognitive neuroscience. This project aims to connect neuroimaging to theories of explanation that focus on the way one variable can make a difference to an ....Changing your mind by changing your brain: An interventionist perspective on cognitive neuroscience. Functional neuroimaging provides a tremendous amount of information about the brain, but what it shows about the mind is less clear. Addressing this fundamental philosophical question requires developing a detailed account of theory-testing in cognitive neuroscience. This project aims to connect neuroimaging to theories of explanation that focus on the way one variable can make a difference to another. By linking neuroimaging to facts about manipulable relationships between the brain and the mind, it will also provide a bridge between neuroimaging and complementary technologies for directly intervening on the brain. This, in turn, will provide a platform from which to explore the theoretical and ethical consequences of direct brain manipulation.Read moreRead less
The Intellectual Construction of Confucianism in Contemporary China and Taiwan. Since the 1980s China and Taiwan have witnessed the most sustained resurgence of intellectual interest in Confucianism of the twentieth century. This project will provide the first critical analysis of that revival by addressing the complex interaction of institutional, philosophical and ideological factors, rather than study one or the other in isolation. This will enable us to understand the processes by which Chi ....The Intellectual Construction of Confucianism in Contemporary China and Taiwan. Since the 1980s China and Taiwan have witnessed the most sustained resurgence of intellectual interest in Confucianism of the twentieth century. This project will provide the first critical analysis of that revival by addressing the complex interaction of institutional, philosophical and ideological factors, rather than study one or the other in isolation. This will enable us to understand the processes by which Chinese intellectuals have sought to make Confucianism a viable philosophical and cultural resource in the modern world; and to evaluate how successful they have been in achieving these goals.
Results: One monograph; one edited volume; several essays.
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Living on the edge: how do Australian plants cope with extreme temperature? Of all the climatic factors determining species distributions, temperature is arguably the most important. It is extremes – rather than averages – that drive species evolution. So it is concerning that although extreme temperature events are increasing in frequency and intensity little is known about the breadth of thermal tolerance of plants from extreme environments. This information is crucial to understand species di ....Living on the edge: how do Australian plants cope with extreme temperature? Of all the climatic factors determining species distributions, temperature is arguably the most important. It is extremes – rather than averages – that drive species evolution. So it is concerning that although extreme temperature events are increasing in frequency and intensity little is known about the breadth of thermal tolerance of plants from extreme environments. This information is crucial to understand species distribution and survival under future climate regimes. This project will ascertain the thermal breadth of Australian species growing in situ and under controlled environments. The project will contribute to development of effective conservation, restoration and rehabilitation plans for Australian native plant communities. Read moreRead less