Disrupted Neurosteroid Synthesis Mediates The Adverse Effects Of Prenatal Stress
Funder
National Health and Medical Research Council
Funding Amount
$695,973.00
Summary
Maternal anxiety and related stress in pregnancy influences the fetus causing developmental changes that adversely affect the offspring leading to behavioural problems in childhood. However, mechanisms which transfer maternal changes to the fetus are unclear. We propose that disruption of the fetal-placental neurosteroid system is a major link. We will identify the deficits in this system caused by maternal stress and then examine therapies to reverse these disruptions.
Early Nutrition, Epigenetics And Developmental Outcomes In Children.
Funder
National Health and Medical Research Council
Funding Amount
$550,093.00
Summary
Increasing evidence demonstrates that early nutrition, including in pregnancy, has long lasting programming effects on later health of children. Evidence implicates epigenetics (literally ‘above DNA’) in mediating these effects. The most convincing data exists for obesity and related disorders such as metabolic syndrome, diabetes, and heart disease. The focus of this project is on understanding how ‘epigenetic’ mechanisms are influencing the way our genes function to cause these disorders.
Finding concurrency bugs in multithreaded software. This project aims to develop sound and practical techniques for detecting and eliminating concurrency bugs for object-oriented languages like Java, enabled by a new model for concurrent effects. The expected outcome is a novel technology that will significantly improve the safety, productivity and efficiency of large-scale concurrent programming.
A Programming Model of Object Validity for Secure and Efficient Concurrency. To provide improved performance and security for software applications, Australia's ICT industry must adapt to the complex programming demands of modern multicore processors. The programming model developed in the project represents a breakthrough solution. A seamless integration of concurrency and object orientation leads to a simple yet powerful programming style that is compatible with today's premier approach to bui ....A Programming Model of Object Validity for Secure and Efficient Concurrency. To provide improved performance and security for software applications, Australia's ICT industry must adapt to the complex programming demands of modern multicore processors. The programming model developed in the project represents a breakthrough solution. A seamless integration of concurrency and object orientation leads to a simple yet powerful programming style that is compatible with today's premier approach to building large-scale software systems with significantly improved performance and security. The product will reduce development time for compute-intensive applications in many industry sectors, including health care (e.g. patient monitoring), finance, defence, environment, mining, manufacturing and computer games.Read moreRead less
Analysis and Optimisation of Incomplete Object-Oriented Programs. This project will push Australia to the forefront of OO technologies and will increase the profile of advanced programming language design and implementation research in Australia. The completed framework will
likely be commercially viable as Australia industries such as banks and
insurance companies and government organisations hosting large
OO software systems may benefit (in terms of performance and
code security) from the ....Analysis and Optimisation of Incomplete Object-Oriented Programs. This project will push Australia to the forefront of OO technologies and will increase the profile of advanced programming language design and implementation research in Australia. The completed framework will
likely be commercially viable as Australia industries such as banks and
insurance companies and government organisations hosting large
OO software systems may benefit (in terms of performance and
code security) from the technology developed as a result of this research. The completed framework will also provide an excellent platform for researchers in Australia and elsewhere to do research in OO technologies, helping in producing quality students for the Australian IT industry.Read moreRead less
Scratchpad-based Memory Allocation Techniques for Embedded Software. This research aims at developing automatic memory allocation algorithms to maximise the effective utilisation of scratchpad memories, which will lead to significantly improved performance and energy usage in embedded applications. The outcomes of this project will provide generic solutions to many Australia-based industries, including telecommunication, network management, sensor networks, automotive and instrumentation/measure ....Scratchpad-based Memory Allocation Techniques for Embedded Software. This research aims at developing automatic memory allocation algorithms to maximise the effective utilisation of scratchpad memories, which will lead to significantly improved performance and energy usage in embedded applications. The outcomes of this project will provide generic solutions to many Australia-based industries, including telecommunication, network management, sensor networks, automotive and instrumentation/measurement, where embedded systems are ubiquitously used. Therefore, this project will significantly contribute to the Priority Area (Frontier Technologies for Building and Transforming Australian Industries), hence fits into its Priority Goal: Frontier Technologies.Read moreRead less
Compiler-Directed Code Tiling for Higher Program Performance and Predictability on Multi-Level Memory Hierarchies. Programming languages invariably induce a perception of memory as being flat, whereas actual computers are being equipped increasingly with deep memory hierarchies to overcome the ever-widening performance gap between processors and memories. This mismatch can result in low locality of reference and poor performance. This project will develop a new array layout transformation, calle ....Compiler-Directed Code Tiling for Higher Program Performance and Predictability on Multi-Level Memory Hierarchies. Programming languages invariably induce a perception of memory as being flat, whereas actual computers are being equipped increasingly with deep memory hierarchies to overcome the ever-widening performance gap between processors and memories. This mismatch can result in low locality of reference and poor performance. This project will develop a new array layout transformation, called data tiling, used in tandem with loop tiling to achieve significantly improved performance gains (and predictability) for array-dominated applications on multi-level memory hierarchies. We will explore this joint restructuring to obtain higher performance and predictability for whole programs, kernel libraries, iterative stencil codes and embedded applications.
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A safe and efficient multi-language component framework based on dynamic compilation. Components are a versatile mechanism for the construction of extendible systems and for improved code reusability. Emerging environments like Microsoft's .NET support the interaction of components written in different programming languages. To date, such systems do not adequately isolate components which therefore must trust each other. This is unacceptable for components loaded across the Internet. We will dev ....A safe and efficient multi-language component framework based on dynamic compilation. Components are a versatile mechanism for the construction of extendible systems and for improved code reusability. Emerging environments like Microsoft's .NET support the interaction of components written in different programming languages. To date, such systems do not adequately isolate components which therefore must trust each other. This is unacceptable for components loaded across the Internet. We will develop a framework for secure execution of component software, based on hardware-enforced protection domains. To minimize the resulting runtime overheads we will provide a component model with lightweight context switching. A novel typed intermediate language and dynamic compilation techniques will offer complementary optimisations.
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Improving Maternal And Infant Outcomes: A Multicentre Randomised Controlled Trial Of Midwifery And Dental Intervention
Funder
National Health and Medical Research Council
Funding Amount
$457,724.00
Summary
Poor oral health during pregnancy can impact the health of the mother and baby. Yet, many expectant mothers are unaware of the implications of poor oral health. In Australia there is a lack of importance being placed on maternal oral health. The aim of this study is to determine the effectiveness of a new service which will promote maternal oral health through collaboration between midwives and dentists. We expect the new service will improve women's oral health, uptake of dental services and po ....Poor oral health during pregnancy can impact the health of the mother and baby. Yet, many expectant mothers are unaware of the implications of poor oral health. In Australia there is a lack of importance being placed on maternal oral health. The aim of this study is to determine the effectiveness of a new service which will promote maternal oral health through collaboration between midwives and dentists. We expect the new service will improve women's oral health, uptake of dental services and potentially improve pregnancy outcomes.Read moreRead less
Towards High-performance and Fault-tolerant Distributed Java Implementations. Java Virtual Machines form an important part of the web and business
server market. Distributed Java Virtual Machines have the potential to
make a significant contribution to industries that utilize this
technology. An attractive platform for this purpose is the
cluster, a highly cost-effective and scalable parallel computer
model. However, realizing on such a platform a high performance virtual
machine implem ....Towards High-performance and Fault-tolerant Distributed Java Implementations. Java Virtual Machines form an important part of the web and business
server market. Distributed Java Virtual Machines have the potential to
make a significant contribution to industries that utilize this
technology. An attractive platform for this purpose is the
cluster, a highly cost-effective and scalable parallel computer
model. However, realizing on such a platform a high performance virtual
machine implementation tolerant to hardware and software faults, and
having efficient memory utilization, presents many challenging research
issues. This project will address these issues by extending a highly
efficient and extensible Java implementation to be aware of its cluster
environment.
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