A Randomised Placebo-controlled Trial Of Antibiotics To Prevent Urinary Tract Infection In Children
Funder
National Health and Medical Research Council
Funding Amount
$735,000.00
Summary
This study is needed to determine whether a common clinical practice long-term antibiotic treatment for children following urinary tract infection (UTI) - is safe and effective in preventing further UTI and if so, whether all appropriate children are being treated. UTI will affect about 10% of Australian children by high school age (88,000 children per year). Because UTI may damage the kidneys, the management priority for children with UTI has been prevention of further infection. Currently this ....This study is needed to determine whether a common clinical practice long-term antibiotic treatment for children following urinary tract infection (UTI) - is safe and effective in preventing further UTI and if so, whether all appropriate children are being treated. UTI will affect about 10% of Australian children by high school age (88,000 children per year). Because UTI may damage the kidneys, the management priority for children with UTI has been prevention of further infection. Currently this means the identification of children thought to be most at risk of recurrent UTI by renal tract imaging. Those found to have reflux of urine from the bladder to the kidney (present in about 30% of those with UTI) are then placed on antibiotics fro 2-5 years. Unfortunately there has never been a properly designed trial to test whether antibiotics do really prevent UTI and if so, whether children with reflux are the appropriate and only group requiring treatment. Long term antibiotics may in fact do more harm than good because of side effects like skin, bowel and blood problems and because resistant bacteria may develop. The design of this study involves the random allocation of placebo or antibiotic (cotrimoxazole, the usual antibiotic given in this case) to about 800 children after their first symptomatic UTI. These children are treated and followed for one year to determine the rate of futher UTI in both groups. Any difference in outcome between the two groups of children will be because of the antibiotic treatment. This study may prove long-term antibiotics are ineffective and therefore should not be routinely used. In this case investigation of children to detect vesicoureteric reflux would serve little purpose and should be abandoned. Alternatively antibiotic treatment may be shown as effective treatment for preventing further UTI and in this case the study will clearly identify those children who will benefit.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100117
Funder
Australian Research Council
Funding Amount
$1,275,000.00
Summary
A platform consortium for integrated 'systems-omics' research. The proposal aims to establish a multi-institutional integrated ‘systems-omics’ platform across two of Victoria’s leading research universities, and associated research institutes. The platform will consist of two cutting edge ultra-high resolution mass spectrometers (i) a Thermo Scientific Orbitrap Fusion LUMOS for rapid and comprehensive metabolomic profiling and detailed structural characterization, located at La Trobe University ....A platform consortium for integrated 'systems-omics' research. The proposal aims to establish a multi-institutional integrated ‘systems-omics’ platform across two of Victoria’s leading research universities, and associated research institutes. The platform will consist of two cutting edge ultra-high resolution mass spectrometers (i) a Thermo Scientific Orbitrap Fusion LUMOS for rapid and comprehensive metabolomic profiling and detailed structural characterization, located at La Trobe University, and (ii) a Thermo Scientific Orbitrap Q Exactive HFX for high-throughput, deep and reproducible quantitative proteome analysis, located at the University of Melbourne.This platform will address applications across the agri-biosciences, medicinal agriculture and fundamental biomedical sciences sectors.Read moreRead less
Amplifying Indigenous news: a digital intervention. This project aims to road-test, document and analyse an innovative strategy for amplifying Indigenous voices in news media. The project will deploy and assess the impact of a new digital application designed to enable access to a diverse range of Indigenous voices, stories and agendas. The anticipated outcomes will assist the project’s industry partners meet their strategic goals of increasing the level of Indigenous media representation in Aus ....Amplifying Indigenous news: a digital intervention. This project aims to road-test, document and analyse an innovative strategy for amplifying Indigenous voices in news media. The project will deploy and assess the impact of a new digital application designed to enable access to a diverse range of Indigenous voices, stories and agendas. The anticipated outcomes will assist the project’s industry partners meet their strategic goals of increasing the level of Indigenous media representation in Australia, and consolidate their roles as leading outlets for Indigenous content and coverage. These outcomes are also expected to improve public understanding of issues affecting Indigenous Australians and contribute to more informed and inclusive policy discussions.Read moreRead less
Virtual Galleries: new media technologies to influence livelihood and arts participation in remote communities of the Northern Territory, Australia. The Virtual Galleries project addresses the issue of limited economic development in remote communities by introducing a user-controlled webcam and interactive 3-D (three-dimensional) Art Galleries into remote art centres to help people in remote communities to secure an income and create wealth and social wellbeing for themselves, their families an ....Virtual Galleries: new media technologies to influence livelihood and arts participation in remote communities of the Northern Territory, Australia. The Virtual Galleries project addresses the issue of limited economic development in remote communities by introducing a user-controlled webcam and interactive 3-D (three-dimensional) Art Galleries into remote art centres to help people in remote communities to secure an income and create wealth and social wellbeing for themselves, their families and their communities.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100015
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
An Ultra High Resolution Mass Spectrometry Facility for Lipidomics Research. An ultra-high-resolution mass spectrometry facility for lipidomics research:
This proposal aims to establish an ultra-high-resolution, accurate mass spectrometry facility in Australia for comprehensive lipidomics research. The platform would consist of a Thermo Scientific Orbitrap Fusion mass spectrometer interfaced with ultra-high-pressure high-performance liquid chromatography. This proposal will address a major need ....An Ultra High Resolution Mass Spectrometry Facility for Lipidomics Research. An ultra-high-resolution mass spectrometry facility for lipidomics research:
This proposal aims to establish an ultra-high-resolution, accurate mass spectrometry facility in Australia for comprehensive lipidomics research. The platform would consist of a Thermo Scientific Orbitrap Fusion mass spectrometer interfaced with ultra-high-pressure high-performance liquid chromatography. This proposal will address a major need for advanced mass spectrometry-based lipid analysis capabilities across mammalian, plant, parasite, and microalgae research disciplines, as well as enabling fundamental studies of lipid separation, chemistry and reactivity. The instrumentation would be applicable to a diverse range of projects including studies of the role of lipid metabolism in mammalian biochemistry and cell biology, plant biology and parasitology, and micro algae biofuel production.Read moreRead less
Indigenous Futurity: Milpirri as Experimental Ceremony. This project aims to develop a long-term research partnership between Warlpiri Indigenous knowledge holders, anthropologists, and community arts industry partner Tracks Dance Company. It will investigate Milpirri Festival as arts innovation, engaging community-members in collective responsibility for Indigenous heritage and futurity. The project will generate new knowledge of Milpirri song, dance, art and story through practice-based rese ....Indigenous Futurity: Milpirri as Experimental Ceremony. This project aims to develop a long-term research partnership between Warlpiri Indigenous knowledge holders, anthropologists, and community arts industry partner Tracks Dance Company. It will investigate Milpirri Festival as arts innovation, engaging community-members in collective responsibility for Indigenous heritage and futurity. The project will generate new knowledge of Milpirri song, dance, art and story through practice-based research with benefits for industry partners and Lajamanu community of increased community participation, outreach and impact.Read moreRead less
Demographic change, ageing and the workforce: An integrated model to inform workforce development and planning in Australia. This project will greatly extend our understanding of the impact of demographic change and ageing on the workforce. It will develop a conceptual framework to strategically inform workforce development and a workforce planning model to assist Australian workplaces to respond to the challenge of demographic change and ageing. The need to develop a better understanding of, an ....Demographic change, ageing and the workforce: An integrated model to inform workforce development and planning in Australia. This project will greatly extend our understanding of the impact of demographic change and ageing on the workforce. It will develop a conceptual framework to strategically inform workforce development and a workforce planning model to assist Australian workplaces to respond to the challenge of demographic change and ageing. The need to develop a better understanding of, and respond to, the implications of demographic change and ageing for workforce development in Australia has been recognised nationally through the National Strategy for Ageing and is of direct relevance to the ARC's national research priority Ageing Well, Ageing Productively. Read moreRead less
Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying ....Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying regulators of lipid metabolism. The large diversity in humans necessitate sufficient sample sizes to identify true genetic regulators, but to date techniques capturing phenotypic data (lipids) have been largely limited. It is anticipated that this study will identify new regulators of lipid metabolism in humans.Read moreRead less
Tectonic geography of the world's oldest petroleum play, the McArthur Basin. This projects aims to develop a 4D tectonic geography framework to support the effective exploration of the McArthur Basin. This project will construct this by a) investigating the evolving tectonic setting, b) examining intra-basin correlations and trace the source to sink sediment provenance, c) unraveling the depositional geography using novel isotopic proxies, and, d) constructing the subsequent thermal history of ....Tectonic geography of the world's oldest petroleum play, the McArthur Basin. This projects aims to develop a 4D tectonic geography framework to support the effective exploration of the McArthur Basin. This project will construct this by a) investigating the evolving tectonic setting, b) examining intra-basin correlations and trace the source to sink sediment provenance, c) unraveling the depositional geography using novel isotopic proxies, and, d) constructing the subsequent thermal history of the basin. The techniques developed through this project will de-risk the exploration for petroleum in this basin, and be applicable in opening up Proterozoic petroleum elsewhere in Australia and internationally.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100049
Funder
Australian Research Council
Funding Amount
$270,000.00
Summary
Nuclear Magnetic Resonance facility for Northern Australia. Nuclear magnetic resonance facility for Northern Australia: Nuclear magnetic resonance spectroscopy is a fundamentally and critically important technique in the characterisation of organic, inorganic and biological compounds. Research areas that will be supported by this facility include organometallic chemistry and the development of new materials and analytical sensors; organic photochemistry as applied in synthesis and degradation; a ....Nuclear Magnetic Resonance facility for Northern Australia. Nuclear magnetic resonance facility for Northern Australia: Nuclear magnetic resonance spectroscopy is a fundamentally and critically important technique in the characterisation of organic, inorganic and biological compounds. Research areas that will be supported by this facility include organometallic chemistry and the development of new materials and analytical sensors; organic photochemistry as applied in synthesis and degradation; and natural products, pharmaceutical, and inorganic chemistry, where multinuclear nuclear magnetic resonance is most important and applicable in drug design, development and delivery.Read moreRead less