This project aims to improve the acute treatment of children with burn injuries through developing more effective and novel treatments and understanding the conditions required for burn injuries to occur.
In this Fellowship I will capitalise on my role as Professor of Surgery and Public Health at Monash University, Director of the National Trauma Research Institute, and a surgeon at The Alfred Hospital, to lead a program of research that improves our understanding of what works in trauma care and trauma systems, uses scientific strategies to ensure research makes a difference to practice and policy, and supports further research that seeks to understand how research can best be used to improve in ....In this Fellowship I will capitalise on my role as Professor of Surgery and Public Health at Monash University, Director of the National Trauma Research Institute, and a surgeon at The Alfred Hospital, to lead a program of research that improves our understanding of what works in trauma care and trauma systems, uses scientific strategies to ensure research makes a difference to practice and policy, and supports further research that seeks to understand how research can best be used to improve injured peoples' lives.Read moreRead less
Identification Of A Plasma Factor Of Remote Ischemic Preconditioning And Its Effect On The Proteome After Heart Surgery
Funder
National Health and Medical Research Council
Funding Amount
$385,197.00
Summary
Heart surgery with the heart placed into arrest causes inflammation and tissue damage due to interrupted circulation. We know that prior brief interruption and restoration of blood supply called remote ischemic preconditioning (IPC) can protect heart and lungs against damage. Our previous studies indicate that IPC involves a circulating factor that protects the tissue by optimizing energy preservation. This knowledge can be applied to organ transplants, protection from stroke and heart attack.
The Biology Of Staphylococcus Epidermidis Biofilm Formation On Silicone Implantable Medical Devices And The Role Of Implant Surface Antibiotic Technology In The Prevention Of Bacterial Biofilm In And Animal Model
Funder
National Health and Medical Research Council
Funding Amount
$113,322.00
Summary
Hospital acquired infections continue to rise with over 60% occuring in patients with medical implants. Infections are due to skin bacteria forming a microscopic slime, or biofilm, around the implant. Biofilm infection is only diagnosed after implant removal, responds poorly to antibiotics, and can cause implant failure, such as joint loosening & bone infection in joint replacements and breast deformity with silicone implants. This project uses an animal model to evaluate different surface treat ....Hospital acquired infections continue to rise with over 60% occuring in patients with medical implants. Infections are due to skin bacteria forming a microscopic slime, or biofilm, around the implant. Biofilm infection is only diagnosed after implant removal, responds poorly to antibiotics, and can cause implant failure, such as joint loosening & bone infection in joint replacements and breast deformity with silicone implants. This project uses an animal model to evaluate different surface treatments to prevent bacterial biofilm formation.Read moreRead less
Pre-hospital Antifibrinolytics For Traumatic Coagulopathy And Haemorrhage (The PATCH Study)
Funder
National Health and Medical Research Council
Funding Amount
$1,668,152.00
Summary
About 2500 Australians die annually from severe injuries. Bleeding is exacerbated by early-onset clotting defects, which are associated with high mortality. The antifibrinolytic agent tranexamic acid has been shown to reduce mortality due to bleeding when given in hospital in less developed trauma systems, but its usefulness as a pre-emptive strike at the scene of injury in developed systems is unknown. Building on our prehospital clinical trials expertise, we will conduct a trial to assess its ....About 2500 Australians die annually from severe injuries. Bleeding is exacerbated by early-onset clotting defects, which are associated with high mortality. The antifibrinolytic agent tranexamic acid has been shown to reduce mortality due to bleeding when given in hospital in less developed trauma systems, but its usefulness as a pre-emptive strike at the scene of injury in developed systems is unknown. Building on our prehospital clinical trials expertise, we will conduct a trial to assess its effect on 6-month death and disability.Read moreRead less
Improving The Pre-hospital Treatment And Acute Management Of Burned Children
Funder
National Health and Medical Research Council
Funding Amount
$359,942.00
Summary
Children’s burns are physically and psychologically debilitating and are a huge burden for the children themselves, their families and the Australian health care system. My work will determine exactly what conditions are required to cause burns so that we can act to prevent them. I will also develop more effective first aid treatment and new treatments to improve burn wound healing.
Refining Methods For Obtaining, Synthesising And Interpreting Research Evidence In Surgery
Funder
National Health and Medical Research Council
Funding Amount
$314,312.00
Summary
Research evidence plays a crucial role in improving clinical care. However the main forms of evidence and the tools that facilitate evidence use - namely randomised controlled trials (RCT) and structured systematic reviews of existing research - have had limited application in surgery for a variety of reasons. This project aims to promote the use of research evidence in surgical decision making by developing tools tailored to the predominance of non-RCTs in surgery and surgeons' information need ....Research evidence plays a crucial role in improving clinical care. However the main forms of evidence and the tools that facilitate evidence use - namely randomised controlled trials (RCT) and structured systematic reviews of existing research - have had limited application in surgery for a variety of reasons. This project aims to promote the use of research evidence in surgical decision making by developing tools tailored to the predominance of non-RCTs in surgery and surgeons' information needs.Read moreRead less