Quantum Generative Diffusion Models for Molecular Research. This project will devise quantum generative diffusion models to equip classical counterparts with the ability to harness quantum data that naturally arise in molecular research. Theoretical foundations for analysing fast sampling methods with the help of inductive bias regarding the input data and employed circuits will validate efficient quantum generative diffusion models that have training and sampling advantages over classical count ....Quantum Generative Diffusion Models for Molecular Research. This project will devise quantum generative diffusion models to equip classical counterparts with the ability to harness quantum data that naturally arise in molecular research. Theoretical foundations for analysing fast sampling methods with the help of inductive bias regarding the input data and employed circuits will validate efficient quantum generative diffusion models that have training and sampling advantages over classical counterparts. Outcomes include applications in molecular conformation generation, compound screening, and drug design. The innovative research will significantly benefit Australia’s science, industry and health, and will maintain Australia’s global leading role in quantum machine learning and molecular research.Read moreRead less
A mental health "thermometer" to monitor and prevent adverse treatment outcomes and self-harm among psychiatric inpatients. Our project stands to prevent adverse outcomes in psychiatric patients. An estimated 660 000 people are admitted to psychiatric hospitals each year; 99 000 of these people are worse off following treatment (assuming a deterioration rate of 15 per cent). Since monitoring can halve that rate, if this project can halve the deterioration rate again, then 24 750 inpatients acr ....A mental health "thermometer" to monitor and prevent adverse treatment outcomes and self-harm among psychiatric inpatients. Our project stands to prevent adverse outcomes in psychiatric patients. An estimated 660 000 people are admitted to psychiatric hospitals each year; 99 000 of these people are worse off following treatment (assuming a deterioration rate of 15 per cent). Since monitoring can halve that rate, if this project can halve the deterioration rate again, then 24 750 inpatients across the nation would not be worse off after treatment representing an annual saving of nearly $19.2 million per annum and reduce the number of patients who fall into a cycle of admission and readmission. Further, although suicide occurs in less than one per cent of admissions, if this research is able to predict and then reduce the suicide rate by as little as 10 per cent, then 660 lives can be saved each year.Read moreRead less
Development of dense gas technology platforms for the formulation of oral vaccines. This project will aim to develop a technology platform that enables the formulation of vaccines that can be delivered orally and this research has the potential to radically change existing vaccination regimens. The availability of needle-free vaccination also has potential for considerable societal and economic impact in developing countries.
A new approach to reversing and preventing immune-mediated diseases. Chronic inflammatory diseases affect up to 20 per cent of Australians. These diseases reduce wellbeing and life potential and shorten lifespan. This project addresses the urgent need for effective therapies and focuses on developing strategies for disease cure and prevention.
Protecting young people from harm and injury: investigating the utility of a risk and protective framework. Serious injuries due to transport, violence and alcohol associated risk-taking are the main cause of teenage death. An innovative school course will be taught and evaluated that increases protecting others from risk, helping injured friends and promoting a connected environment where teachers and peers reach out to provide support.
Short sleep as a cause of obesity: a longitudinal examination of Australian children and adults. This project will examine whether short sleep durations predict weight gain and obesity in Australian children and adults. The findings will have potentially important implications for how obesity is treated and prevented in Australia.
Development and evaluation of morality curriculum intervention for children in Year 7 to reduce uptake of alcohol and tobacco in high school use. This project builds on previous research that supports the notion that a moral stance against alcohol and tobacco use has a protective effect on uptake of these substances. This study aims to develop morality curriculum components on alcohol and tobacco use for children in Year 7, and to determine the effectiveness of these morality components on preve ....Development and evaluation of morality curriculum intervention for children in Year 7 to reduce uptake of alcohol and tobacco in high school use. This project builds on previous research that supports the notion that a moral stance against alcohol and tobacco use has a protective effect on uptake of these substances. This study aims to develop morality curriculum components on alcohol and tobacco use for children in Year 7, and to determine the effectiveness of these morality components on preventing uptake of alcohol and tobacco use in early secondary school (Years 8 and 9). School-based interventions to date have ignored morality issues in their alcohol and tobacco control interventions. The output of this study will be the development of evidence-based morality curriculum components to enhance the effect of existing school-based interventions on alcohol and tobacco use.Read moreRead less
Highly multiplexed rapid-analysis microarrays for early disease diagnosis. Molecular diagnostics are revolutionising the treatment of disease in hospitals by providing rapid and accurate identification of pathogens; saving costs, time and lives. This project will accelerate this revolution by combining new array technology from the University of Sydney with a proven multiplex method from the Sydney based company, AusDiagnostics.
The effect of a practice change intervention in increasing, on a network-wide basis, the provision of preventive care by community health clinicians. Community health services do not routinely deliver care that aims to decrease client health risk behaviours. The effectiveness of an intervention designed to enhance the delivery of such care will be examined.
From risk factor analysis to translation: multiple sclerosis and vitamin D deficiency. This research on multiple sclerosis will focus on its causes and lifestyle factors that affect it and will trial vitamin D supplementation as a treatment. Studies on vitamin D deficiency in healthy populations aim to develop new public health recommendations on sun exposure and vitamin D that balance risk of skin cancer against vitamin D deficiency.