Development of a new diet to improve insulin sensitivity and manage weight in healthy cats. This project will determine if a low carbohydrate, moderate fat, high protein diet improves insulin sensitivity and reduces weight gain in cats compared to a typical high-carbohydrate grocery line diet. It will identify risk factors for weight gain such as increased fasting insulin concentration and will also determine which simple assessment of insulin sensitivity best correlates with insulin sensitivity ....Development of a new diet to improve insulin sensitivity and manage weight in healthy cats. This project will determine if a low carbohydrate, moderate fat, high protein diet improves insulin sensitivity and reduces weight gain in cats compared to a typical high-carbohydrate grocery line diet. It will identify risk factors for weight gain such as increased fasting insulin concentration and will also determine which simple assessment of insulin sensitivity best correlates with insulin sensitivity measured by a gold standard. This project should lead to the formulation of a diet designed to improve insulin sensitivity and minimize weight gain in cats, and allow for earlier identification of cats at risk of obesity.Read moreRead less
Mechanisms of manchette function. This project aims to define the function of the manchette, a poorly understood microtubule-based structure present in haploid male germ cells. This project aims to define key mechanisms underpinning manchette development and movement, and to generate a detailed picture of the dynamics of germ cell development using imaging technologies and unique animal models. Such knowledge should improve the understanding of how male fertility is achieved, the origin of infer ....Mechanisms of manchette function. This project aims to define the function of the manchette, a poorly understood microtubule-based structure present in haploid male germ cells. This project aims to define key mechanisms underpinning manchette development and movement, and to generate a detailed picture of the dynamics of germ cell development using imaging technologies and unique animal models. Such knowledge should improve the understanding of how male fertility is achieved, the origin of infertility and how species-specific differences in sperm form are achieved. Such insights may ultimately lead to improved agricultural efficiencies and job creation.Read moreRead less
The routes of infection with sheep scrapie and agents that cause related prion diseases. We will define the routes by which the infective agents for scrapie, a debilitating disease of sheep, reach the nervous system after being consumed with food. Scrapie is from the same disease group (prion diseases) as mad cow disease. There would be a large economic cost were prion diseases to infect agricultural animals in Australia, through bioterrorism or accident. An outbreak in sheep could ruin the indu ....The routes of infection with sheep scrapie and agents that cause related prion diseases. We will define the routes by which the infective agents for scrapie, a debilitating disease of sheep, reach the nervous system after being consumed with food. Scrapie is from the same disease group (prion diseases) as mad cow disease. There would be a large economic cost were prion diseases to infect agricultural animals in Australia, through bioterrorism or accident. An outbreak in sheep could ruin the industry, as our export markets would be immediately blocked, and thousands of animals would be killed to stop disease spread. The benefit of clearly understanding how the infective agents reach the nervous system is that this may lead to strategies to intervene, and thus limit the spread and seriousness of infection.Read moreRead less
Controlling Anisotropic Growth of Metal Oxide Crystals in Aqueous Solution by Selective Adsorption of Small Molecules. The proposed research will enhance our ability to make both light emitting diodes (LEDs) and piezoelectric actuators from ZnO. LEDs are a high efficiency light source that save energy compared to conventional illumination sources and can be fabricated in thin films. The proposal is to also bring the technology for device fabrication to Australia where it can ultimately be used ....Controlling Anisotropic Growth of Metal Oxide Crystals in Aqueous Solution by Selective Adsorption of Small Molecules. The proposed research will enhance our ability to make both light emitting diodes (LEDs) and piezoelectric actuators from ZnO. LEDs are a high efficiency light source that save energy compared to conventional illumination sources and can be fabricated in thin films. The proposal is to also bring the technology for device fabrication to Australia where it can ultimately be used to broaden the economic base of the country. The knowledge of crystal growth rate and crystal morphology control can be applied to improvements in the efficiency of alumina production which is already an important contributor to Australian exports.Read moreRead less
Characterisation and Mitigation of Caustic Cracking: A Safety and Maintenance Concern in Alumina and Pulp-and-Paper Processing. Extraction of alumina from mineral bauxite (Bayer process) and pulp-and-paper processing (Kraft process) are major industries in Australia. Cracking of reaction vessels, digesters, cleaning tanks and pipework are major concern for plant integrity, occupational health, safety and environment. Caustic cracking is often the first suspect when a failure occurs. The propose ....Characterisation and Mitigation of Caustic Cracking: A Safety and Maintenance Concern in Alumina and Pulp-and-Paper Processing. Extraction of alumina from mineral bauxite (Bayer process) and pulp-and-paper processing (Kraft process) are major industries in Australia. Cracking of reaction vessels, digesters, cleaning tanks and pipework are major concern for plant integrity, occupational health, safety and environment. Caustic cracking is often the first suspect when a failure occurs. The proposed program will investigate the role of critical impurities and additives, temperature and stress fluctuations in caustic cracking of mild steel and their weldments (known to be most susceptible). This project will also develop an intellectual and infrastructural base that will also be a vital resource for several Australian industries where such cracking is a major concern.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100054
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
How plants respond to cell wall signals. This project aims to discover mechanisms of plant cell wall signalling and modify plant cell walls for improved food, textiles, building materials and renewable biofuels without inadvertently activating cell wall signalling. However, attempts to improve cell walls have been ineffective because it is not known how plants use cell wall signalling to sense and compensate for cell wall changes. This project expects to develop both a genetic screen to find mut ....How plants respond to cell wall signals. This project aims to discover mechanisms of plant cell wall signalling and modify plant cell walls for improved food, textiles, building materials and renewable biofuels without inadvertently activating cell wall signalling. However, attempts to improve cell walls have been ineffective because it is not known how plants use cell wall signalling to sense and compensate for cell wall changes. This project expects to develop both a genetic screen to find mutants defective in cell wall signal transduction and a bioinformatic tool to compare genomes across species and discover cell wall signalling components. Potential benefits include addressing Australian research priorities: Food, Environmental Change, and Energy.Read moreRead less
Biological control of grapevine scales. Wine grapes can be grown with a minimum of pesticide and fungicide applications in some regions, but biological control is still required to maintain populations of major pests. This project is concerned with grapevine and frosted scales, which are common pests of grapevines. The distribution and identity of different grapevine scales, and their main parasitoids, in the various grape growing regions of Australia will be determined by initial surveys. Exper ....Biological control of grapevine scales. Wine grapes can be grown with a minimum of pesticide and fungicide applications in some regions, but biological control is still required to maintain populations of major pests. This project is concerned with grapevine and frosted scales, which are common pests of grapevines. The distribution and identity of different grapevine scales, and their main parasitoids, in the various grape growing regions of Australia will be determined by initial surveys. Experiments and laboratory studies of the interaction of the various predators and parasitoids will be undertaken to develop a biological control program of the scales aimed at reducing pesticide input.Read moreRead less
Tailoring physiologically-based nanomaterial fertilisers for the biofortification of zinc in broadacre crops. Soil zinc deficiency is a global issue causing low crop yield and malnutrition. This project will develop a new class of fertiliser formulations by combining advanced chemistry techniques with plant physiology knowledge and nanomaterial manufacturing. These products will be designed for enhanced agronomic efficiency and environmental safety.
Small molecules with large effect: The dual role of nitrogen-containing metabolites in stress tolerance and nutrient recycling. The main objective of this project is to identify drought and nutrient-deficiency responsive pathways in tolerant wheat and to provide markers to breeding programs that facilitate selection of superior breeding lines. This project builds on a pilot study conducted in rice in which tolerant-specific metabolites were identified which are representative of pathways relevan ....Small molecules with large effect: The dual role of nitrogen-containing metabolites in stress tolerance and nutrient recycling. The main objective of this project is to identify drought and nutrient-deficiency responsive pathways in tolerant wheat and to provide markers to breeding programs that facilitate selection of superior breeding lines. This project builds on a pilot study conducted in rice in which tolerant-specific metabolites were identified which are representative of pathways relevant for the protection of cells from damage through reactive oxygen species (ROS) and for nutrient (nitrogen, phosphorus, sugars) recycling under stress. Available data suggest that these pathways are also relevant in wheat. Quantitative metabolomics, genetics, and molecular tools will be used to deliver either DNA-based or metabolomics markers to breeders.Read moreRead less
Methane and nitrous oxide in agro-ecological systems: novel technologies and understandings to improve ecosystem management. Methane and nitrous oxide are critical greenhouse gases but globally we lack ecosystem scale analyses of the balance of emissions, including animal emissions, and soil oxidation. This project will quantify this balance for a range of agro-ecosystems, and explore and develop opportunities for improving soil-based Greenhouse Gas (GHG) mitigation measures.