Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100090
Funder
Australian Research Council
Funding Amount
$1,136,244.00
Summary
Xe-plasma dual beam for advanced future materials. This project aims to establish a state of the art Xe-Plasma dual-beam facility providing characterisation and fabrication capabilities to Australia’s research community. The project will use two beams - one Xe, the other electrons - to mill the surface of bulk materials which are subsequently analysed by electron or ion beam techniques to determine atomic-scale microstructure(s) and compositions. Anticipated outcomes are advanced materials engin ....Xe-plasma dual beam for advanced future materials. This project aims to establish a state of the art Xe-Plasma dual-beam facility providing characterisation and fabrication capabilities to Australia’s research community. The project will use two beams - one Xe, the other electrons - to mill the surface of bulk materials which are subsequently analysed by electron or ion beam techniques to determine atomic-scale microstructure(s) and compositions. Anticipated outcomes are advanced materials engineering and new knowledge about ancient and future materials. This is expected to provide significant advances across a variety of fields including material science, engineering and geology and enhance trans-disciplinary collaborations.Read moreRead less
Dislocation motion and anelastic recovery in layered ceramic titanate. This project aims to research deformation and facture in brittle ceramic nanowire materials and anelastic behaviour in tensile deformation. Layered sodium titanate is used in energy storage and water treatment, but in-situ tensile tests have observed unconventional deformation behaviour, with significant dislocation motion and anelastic recovery. This project will study the deformation mechanism in layered sodium titanate nan ....Dislocation motion and anelastic recovery in layered ceramic titanate. This project aims to research deformation and facture in brittle ceramic nanowire materials and anelastic behaviour in tensile deformation. Layered sodium titanate is used in energy storage and water treatment, but in-situ tensile tests have observed unconventional deformation behaviour, with significant dislocation motion and anelastic recovery. This project will study the deformation mechanism in layered sodium titanate nanowires through molecular dynamics simulations, empirical interatomic potential, and in situ TEM experiments. Expected outcomes include knowledge of the deformation mechanism of this layered titanate which can be broadened to technologically important layered ceramic materials.Read moreRead less
New approaches to functional and structural genomics. Genome sequencing has revealed complete sets of macromolecules that make up our cells. We now need to learn how these macromolecules work together in a coordinated fashion. The proposed research will lead to the discovery of new biological molecules, interactions and processes essential for the function of cells, identify new therapeutic targets and strategies to combat disease, identify new concepts in bio- and nanotechnology, and train new ....New approaches to functional and structural genomics. Genome sequencing has revealed complete sets of macromolecules that make up our cells. We now need to learn how these macromolecules work together in a coordinated fashion. The proposed research will lead to the discovery of new biological molecules, interactions and processes essential for the function of cells, identify new therapeutic targets and strategies to combat disease, identify new concepts in bio- and nanotechnology, and train new interdisciplinary researchers. It will underpin the National Research Priorities (Frontier Technologies for Building and Transforming Australian Industries, and Promoting and Maintaining Good Health) and help Australia capitalise on a plethora of opportunities for future economic and health benefits.Read moreRead less
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Understanding grain boundary segregation - a route to developing new advanced engineering materials. This project will investigate atomic-scale grain boundary segregation - one of the most important factors influencing the properties of engineering alloys. This will be applied in the development of new Ti, Zr and nanocrystalline alloys with a large potential market and for which Australia is extremely well positioned to become a major producer.
Folding and dynamics of bioengineered cyclic cystine knot proteins. This project will increase knowledge of the structure and function of an important family of proteins, namely the conotoxins. Conotoxins are of particular interest in Australia as nearly 300 species of cone snails occur in Australian waters and they represent a rich source of novel peptides for drug discovery. This project will enhance their stability by altering their structures and will have a direct impact on peptide-drug ba ....Folding and dynamics of bioengineered cyclic cystine knot proteins. This project will increase knowledge of the structure and function of an important family of proteins, namely the conotoxins. Conotoxins are of particular interest in Australia as nearly 300 species of cone snails occur in Australian waters and they represent a rich source of novel peptides for drug discovery. This project will enhance their stability by altering their structures and will have a direct impact on peptide-drug based therapies, resulting in economic and social benefits for Australian society. Additionally, some peptides under study have agricultural significance for crop protection and this too, has the potential to provide significant economic benefits. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100141
Funder
Australian Research Council
Funding Amount
$310,000.00
Summary
High resolution nuclear magnetic resonance spectroscopy for glycomics, metabonomics and soft materials applications. This project will enhance the nuclear magnetic resonance spectroscopy capabilities and the world class research being undertaken at the Institute for Glycomics, Griffith University and Queensland University of Technology. This powerful technique can contribute information in diverse research areas such as glycomics, metabonomics and soft materials research.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100087
Funder
Australian Research Council
Funding Amount
$410,000.00
Summary
Advanced Macromolecular Materials Characterisation Facility (AMMCF). Advanced macromolecular materials characterisation facility: The facility will allow precise characterisation of (bio)macromolecular materials, from chemical structures and composition as a function of size or biodistribution, to film thickness in multi-layer materials, to material hydrophobicity and permeability. Novel information derived from these state-of-the-art instruments is highly valuable in understanding structure-pro ....Advanced Macromolecular Materials Characterisation Facility (AMMCF). Advanced macromolecular materials characterisation facility: The facility will allow precise characterisation of (bio)macromolecular materials, from chemical structures and composition as a function of size or biodistribution, to film thickness in multi-layer materials, to material hydrophobicity and permeability. Novel information derived from these state-of-the-art instruments is highly valuable in understanding structure-property relationships, which are crucial for the development of the next generation of advanced materials with applications in electronics, optics, sensors, membranes, nanocoatings, biomaterials and polymer therapeutics. This facility underpins the efforts of the participating institutes in increasing the quality and quantity of research outcomes.Read moreRead less
Markers of milk quality in commercially produced UHT milks and milk powders. Efficient production of safe, wholesome food relies on the application of the best available knowledge of the food material and the processing technologies involved. This project applies proteomics, the most advanced protein analysis technique, to determine the changes that occur in milk during high heat treatment and subsequent storage of the heat-processed milk product. Armed with such knowledge, the dairy processin ....Markers of milk quality in commercially produced UHT milks and milk powders. Efficient production of safe, wholesome food relies on the application of the best available knowledge of the food material and the processing technologies involved. This project applies proteomics, the most advanced protein analysis technique, to determine the changes that occur in milk during high heat treatment and subsequent storage of the heat-processed milk product. Armed with such knowledge, the dairy processing industry will be able to make informed decisions about processing and storage conditions to ensure the final products provided to the consumer are of the highest possible quality. Read moreRead less
Development of Novel Detergents for Green Solvent Systems and Their Self-Assembly into Nanostructures. Successful outcomes from this collaborative project will lead to the development of new commercially viable green solvent systems for the chemical industry, e.g. dry cleaning. This has the potential to impact the community on the economic and environmental level, by significantly reducing the costs of current green solvent systems, resulting in greater likelihood of conventional toxic solvent ....Development of Novel Detergents for Green Solvent Systems and Their Self-Assembly into Nanostructures. Successful outcomes from this collaborative project will lead to the development of new commercially viable green solvent systems for the chemical industry, e.g. dry cleaning. This has the potential to impact the community on the economic and environmental level, by significantly reducing the costs of current green solvent systems, resulting in greater likelihood of conventional toxic solvents being replaced. The project will also expand the training of junior and early career scientists by allowing them to work in overseas laboratories.Read moreRead less