Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Fluid-thermal-structural interactions on high-speed aerospace vehicles. Sixteen years after the retirement of Concorde, high-speed commercial flight is once again on the rise with the development of new supersonic business jets and small airliners as well as hypersonic transport and reusable space launch systems. Robust and efficient designs for these light-weight vehicles must address the problem of aerodynamic heating and its effect on structural performance and lifing. This project will desig ....Fluid-thermal-structural interactions on high-speed aerospace vehicles. Sixteen years after the retirement of Concorde, high-speed commercial flight is once again on the rise with the development of new supersonic business jets and small airliners as well as hypersonic transport and reusable space launch systems. Robust and efficient designs for these light-weight vehicles must address the problem of aerodynamic heating and its effect on structural performance and lifing. This project will design and perform first-of-kind experiments that reproduce the complex fluid-thermal-structural interactions representative of those experienced by these aircraft and rockets. We will then use these measurements to assess, validate and improve the current state-of-the-art of simulation and modelling approaches for design.Read moreRead less
Fluid-structural interactions in high-speed flows. This project aims to perform experiments to measure fluid-structure interaction in hypersonic flows. The work will improve the accuracy of simulation tools that are urgently required to aid industry in the design of more structurally efficient and robust high-speed vehicles. These tools will in turn be used to reveal the underlying physics of the fluid-structure interactions and establish the relative significance of the driving parameters. Accu ....Fluid-structural interactions in high-speed flows. This project aims to perform experiments to measure fluid-structure interaction in hypersonic flows. The work will improve the accuracy of simulation tools that are urgently required to aid industry in the design of more structurally efficient and robust high-speed vehicles. These tools will in turn be used to reveal the underlying physics of the fluid-structure interactions and establish the relative significance of the driving parameters. Accurate prediction of the behaviour and lifetime of structural components subject to these fluid-structural interactions, in which the deformation of the structure induced by the local flow field, can in turn influence this flow field. This coupling can result in damage or even catastrophic structural failure and thus robust design tools must be developed to avoid this.Read moreRead less
Dispersion of spacecraft components during re-entry. Destructive re-entry trajectories for used satellites are designed so debris remaining after re-entry falls harmlessly to the Earth. However, the dramatic increase in the mass of orbiting objects has outpaced improvements in predicting hazardous impact zones. This project aims to develop the experimental and theoretical methods needed to study separation of objects in hypersonic flow in order to better predict the dispersion of debris from re- ....Dispersion of spacecraft components during re-entry. Destructive re-entry trajectories for used satellites are designed so debris remaining after re-entry falls harmlessly to the Earth. However, the dramatic increase in the mass of orbiting objects has outpaced improvements in predicting hazardous impact zones. This project aims to develop the experimental and theoretical methods needed to study separation of objects in hypersonic flow in order to better predict the dispersion of debris from re-entering space objects. New hypersonic wind tunnel experiments, modelling, and computational simulations will be performed to enhance our understanding and improve predictions of how spacecraft components are dispersed during re-entry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100051
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Fabrication and characterisation facilities for lithium rechargeable batteries and supercapacitors. The facility, unlike any currently existing in Australia, will help researchers studying electrodes and cells at a high level. It will provide a new path to high-level research performance and will significantly enhance Australia’s research capability to bring new materials/technologies under development closer to application.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100157
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information th ....Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information that is not easily obtainable with other approaches. The project will enable Australian researchers to image and analyse the full complexity of biological systems, potentially transforming cell biology, drug development and understanding the molecular basis of disease. It will also demonstrate how the capacity of microscopy facilities can be enhanced and bias in imaging data reduced by automating data acquisition and mining of image-based data.Read moreRead less
Airports of the Future. This project will enhance the capabilities of Australian airport operators to design and manage complex airport systems. Research outcomes will enable the identification of patterns of behaviour and will provide tools to manage airport effectiveness and balance conflicting security, economic and passenger-driven pressures. Outcomes will improve productivity, enhance capabilities for critical infrastructure protection, and lessen the cost of mandated security, estimated t ....Airports of the Future. This project will enhance the capabilities of Australian airport operators to design and manage complex airport systems. Research outcomes will enable the identification of patterns of behaviour and will provide tools to manage airport effectiveness and balance conflicting security, economic and passenger-driven pressures. Outcomes will improve productivity, enhance capabilities for critical infrastructure protection, and lessen the cost of mandated security, estimated to grow to $152M by 2010 for the five major Australian airports. The deliverables of this project will be transferable to other complex socio-technical systems providing the potential to transform a range of Australian critical infrastructure and transportation hubs.Read moreRead less
High performance cast magnesium alloys. Reducing the weight of cars, particularly their engines, enables substantial reductions in fuel consumption and greenhouse gas emissions. A new generation of magnesium alloys will be developed by this project for the manufacture of considerably lighter components with improved mechanical performance for powertrain and structural applications.
Economically efficient green logistics through cyber physical systems. Economically efficient green logistics through cyber physical systems. This project aims to realize green logistics by researching how to run diesel-powered heavy-duty milk trucks economically and efficiently on liquefied natural gas (LNG) and demonstrating to logistics companies that LNG conversion will reduce operating costs and emissions. Transportation systems account for 18% of Australia's carbon emissions, and diesel-po ....Economically efficient green logistics through cyber physical systems. Economically efficient green logistics through cyber physical systems. This project aims to realize green logistics by researching how to run diesel-powered heavy-duty milk trucks economically and efficiently on liquefied natural gas (LNG) and demonstrating to logistics companies that LNG conversion will reduce operating costs and emissions. Transportation systems account for 18% of Australia's carbon emissions, and diesel-powered logistics vehicles are a major contributor. However, converting these trucks to LNG requires strong evidence to convince logistics companies of the benefits of shifting to green logistics. An increase in logistics productivity is expected to increase Australia’s gross domestic product by $2 billion, while this research should also provide vital data on sustainability issues and LNG conversions.Read moreRead less
Airborne ultrafine particles in Australian cities. There is an acute deficiency of knowledge in Australia on urban airborne ultrafine particles, originating from transport and other anthropogenic sources, which pose significant health and environmental risks. The aim of this project is to address this deficiency by an extensive multi-city, cross-disciplinary study using state of the art instrumentation and data analytic techniques. The outcome will be an in depth, quantitative insight into the c ....Airborne ultrafine particles in Australian cities. There is an acute deficiency of knowledge in Australia on urban airborne ultrafine particles, originating from transport and other anthropogenic sources, which pose significant health and environmental risks. The aim of this project is to address this deficiency by an extensive multi-city, cross-disciplinary study using state of the art instrumentation and data analytic techniques. The outcome will be an in depth, quantitative insight into the characteristics of the particles, their sources and spatial and temporal variation across different urban areas and time scales. Further, the impacts of changing fuels, vehicle technologies, and climate on future trends of the particles will be elucidated.Read moreRead less