Diamonds in ophiolite: recycling deep mantle into supra-subduction zones. This project aims to investigate whether the discovery of diamonds in oceanic rocks, known as ophiolites, is a global phenomenon. Even half a century after the introduction of plate tectonic theory, significant knowledge gaps remain regarding the fate of subducted lithosphere and Earth processes deep within the mantle. This project will use Australasian examples to test the hypothesis that diamonds are ubiquitous in the ma ....Diamonds in ophiolite: recycling deep mantle into supra-subduction zones. This project aims to investigate whether the discovery of diamonds in oceanic rocks, known as ophiolites, is a global phenomenon. Even half a century after the introduction of plate tectonic theory, significant knowledge gaps remain regarding the fate of subducted lithosphere and Earth processes deep within the mantle. This project will use Australasian examples to test the hypothesis that diamonds are ubiquitous in the mantle and occur widely in ophiolites. Results will have major implications for our understanding of how ocean crust grows and how rocks in the upper mantle form, as well as providing insight into how organic carbon is cycled from the seabed deep into the mantle before being returned back to Earth's surface.Read moreRead less
Phosphate stabilisation of metalliferous mine wastes: The key to solving a major environmental issue? Mine wastes represent the greatest proportion of solid waste produced by mankind. Unconstrained drainage from sulfide-rich mine wastes impacts on water, soil and sediment quality. This project will establish the scientific principles of phosphate stabilisation, which involves the addition of phosphate compounds to mine wastes and soils to permanently contain metals and acid. A solid understandin ....Phosphate stabilisation of metalliferous mine wastes: The key to solving a major environmental issue? Mine wastes represent the greatest proportion of solid waste produced by mankind. Unconstrained drainage from sulfide-rich mine wastes impacts on water, soil and sediment quality. This project will establish the scientific principles of phosphate stabilisation, which involves the addition of phosphate compounds to mine wastes and soils to permanently contain metals and acid. A solid understanding of this emerging technology is a prerequisite for any sustainable management of mine sites. The study will provide the foundation of future management tools needed by landholders, industry and regulators to remediate mined land and waste repositories.Read moreRead less
Deep time in the deep Earth: using trace element diffusivities to constrain durations of deep Earth processes. Evaluation of deep Earth resources requires knowing how long geological processes took, some record of which is often preserved by gradients in the chemical compositions of minerals. Experiments at very high temperatures and pressures will determine how this evidence can be used to constrain the durations of a rich variety of geological processes.
A fundamental study of the role of signal transduction pathways in the regulation of Chlamydia's complex developmental cycle. Chlamydia are unique organisms in the microbial world. They are among the smallest bacteria and yet have a complex two-stage developmental cycle. In addition they are major causes of disease in animals and humans with no vaccines available. We have used the recent flood of full genome sequence data to identify over 30 new cell signalling proteins. By understanding how the ....A fundamental study of the role of signal transduction pathways in the regulation of Chlamydia's complex developmental cycle. Chlamydia are unique organisms in the microbial world. They are among the smallest bacteria and yet have a complex two-stage developmental cycle. In addition they are major causes of disease in animals and humans with no vaccines available. We have used the recent flood of full genome sequence data to identify over 30 new cell signalling proteins. By understanding how these cell signaling proteins are organized into pathways and how this microorganism controls its complex growth and developmental cycle, we will be able to develop novel methods of control. We are at the fore front of international research and therefore uniquely placed to conduct this project.Read moreRead less
Voltage-dependent structural changes in voltage-gated sodium channels. This project aims to provide insights into the structural rearrangements experienced by Nav channels, which are key components of animal nervous systems. Voltage-gated sodium (Nav) channels initiate action potentials in excitable cells. They open in response to membrane depolarisation then rapidly inactivate. Eukaryotic Nav channels contain four unique voltage-sensor domains (VSDs) that control how the channel responds to mem ....Voltage-dependent structural changes in voltage-gated sodium channels. This project aims to provide insights into the structural rearrangements experienced by Nav channels, which are key components of animal nervous systems. Voltage-gated sodium (Nav) channels initiate action potentials in excitable cells. They open in response to membrane depolarisation then rapidly inactivate. Eukaryotic Nav channels contain four unique voltage-sensor domains (VSDs) that control how the channel responds to membrane potential changes. Recently reported crystal structures of bacterial Nav channels have greatly advanced the field, but these channels contain four identical VSDs and have different inactivation properties. Thus, much remains to be learnt about the conformational plasticity of eukaryotic Nav channel VSDs. The project plans to use animal toxins to capture eukaryotic VSDs in defined states of the gating cycle for detailed structural analysis using nuclear magnetic resonance and X-ray crystallography.Read moreRead less
SNARE-mediated perforin and cytokine release in natural killer cells. Cytotoxic cells release toxic granules and cytokine messengers to kill pathogen infected and cancerous cells and to mount immune responses. This project will investigate different SNARE molecules that regulate the secretion of perforin from granules and cytokines from other carriers, assisting in the understanding of complex but essential cellular pathways.
Signalling cross-talk through Suppressors Of Cytokine Signalling (SOCS) initiates luteolysis in the ovary. Members of the newly discovered SOCS protein family block cytokine signal transduction pathways, including those for prolactin and GH. We have discovered that one of these proteins, SOCS-3, is upregulated in the corpus luteum of the ovary by prostaglandins and propose that induction of prolactin or GH resistance is a hitherto unrecognised and critical step in luteolysis. We have also disco ....Signalling cross-talk through Suppressors Of Cytokine Signalling (SOCS) initiates luteolysis in the ovary. Members of the newly discovered SOCS protein family block cytokine signal transduction pathways, including those for prolactin and GH. We have discovered that one of these proteins, SOCS-3, is upregulated in the corpus luteum of the ovary by prostaglandins and propose that induction of prolactin or GH resistance is a hitherto unrecognised and critical step in luteolysis. We have also discovered that this cross-talk between prostaglandin- and cytokine-receptor signalling pathways occurs in preadipocyte and breast cell lines and propose that this research will serve as a paradigm for understanding how sensitivity to cytokines can be controlled at a molecular level.Read moreRead less
Formation of the Chlamydial Inclusion Requires Host Trafficking Pathways. Using cellular and biochemical approaches this project aims to examine the membrane trafficking pathways hijacked by the pathogen Chlamydia and to define the key components of these pathways. Chlamydia are obligate intracellular pathogens responsible for a range of human and animal diseases. In order to survive within the host cell, the pathogen hijacks the host's membrane trafficking pathways to engineer an intracellular ....Formation of the Chlamydial Inclusion Requires Host Trafficking Pathways. Using cellular and biochemical approaches this project aims to examine the membrane trafficking pathways hijacked by the pathogen Chlamydia and to define the key components of these pathways. Chlamydia are obligate intracellular pathogens responsible for a range of human and animal diseases. In order to survive within the host cell, the pathogen hijacks the host's membrane trafficking pathways to engineer an intracellular niche called an inclusion. In addition to providing a permissive environment, this strategy also shields the pathogen from the host's immune system.Read moreRead less
The geochemistry of rare earth elements in carbonate melts. This project aims to determine why deposits of rare earth elements, which are critical for modern devices and technologies such as phones, tablets and plasma screens, are associated with carbonate magmas. The global supply of these critical metals is geopolitically unstable and, although Australia has significant reserves, there is very limited production. By improving our understanding of the geochemical behaviour of the rare earths th ....The geochemistry of rare earth elements in carbonate melts. This project aims to determine why deposits of rare earth elements, which are critical for modern devices and technologies such as phones, tablets and plasma screens, are associated with carbonate magmas. The global supply of these critical metals is geopolitically unstable and, although Australia has significant reserves, there is very limited production. By improving our understanding of the geochemical behaviour of the rare earths this project aims to develop new reverse-engineering methods for their extraction, which will improve the security of supply of these elements and enhance Australia's role in high-tech industries. The project will enhance the profitability of the Australian resources sector through improved extraction economics and will secure the supply of these critical metals for Australian high-tech industries and export. The outcomes will be targeted initially at junior resource companies that are not yet profitable.Read moreRead less
Organising Intracellular Compartments by Formation of Transport Carriers. This project aims to investigate the cellular components which generate carriers that transport material between compartments within the cell. The process of sorting proteins and sending them to the right place is a fundamental mechanism critical to understand how individual proteins function as the move around within cells. The generated knowledge about how cells organise themselves through the movement of proteins betwee ....Organising Intracellular Compartments by Formation of Transport Carriers. This project aims to investigate the cellular components which generate carriers that transport material between compartments within the cell. The process of sorting proteins and sending them to the right place is a fundamental mechanism critical to understand how individual proteins function as the move around within cells. The generated knowledge about how cells organise themselves through the movement of proteins between endosomal intracellular compartments will provide significant benefits by enhancing our capacity to understand this conserved cellular pathway which ensures the integrity of all cellular processes including signalling, communication, homeostasis and development.Read moreRead less