The Structural Basis For Glutamate Transporter Function
Funder
National Health and Medical Research Council
Funding Amount
$373,144.00
Summary
Glutamate transporters are vacuum cleaners in the brain that suck the neurotransmitter glutamate into cells. When the glutamate vacuum breaks down or becomes blocked, glutamate levels outside cells increase, leading to cell death in the brain. This process underlies the damage in many brain diseases including Alzheimer’s disease and stroke. The aim of this project is to understand the mechanism of the glutamate vacuum cleaner so we can develop therapeutics to fix it when it breaks down.
Structural And Functional Studies On RNA Nuclear Retention Mediated By Paraspeckles: A Novel Gene Regulation
Funder
National Health and Medical Research Council
Funding Amount
$290,978.00
Summary
Dynamic interactions between proteins and nucleic acids are essential process in gene regulation, where aberrant regulation leads to various diseases including cancers. The project aims to examine the interactions between paraspeckle proteins and nucleic acid molecules via determination of the structures of protein-nucleic acid complexes at the atomic level. The results will provide a better understanding of a recently discovered gene regulation mechanism and a basis for new gene therapy.
Optimum control of the in-use performance of talc-based compositions. It is important to improve the quality of their Talcom body powder, baby powder and other cosmetic products involving talc. The areas that can and need to be improved are shining characteristics, assessing the slip properties as well as developing the cosmetic chemistry of talc and other additives. The proposed project will generate: a) simple but reliable test methods for measuring slip and shine, b) methods for control of t ....Optimum control of the in-use performance of talc-based compositions. It is important to improve the quality of their Talcom body powder, baby powder and other cosmetic products involving talc. The areas that can and need to be improved are shining characteristics, assessing the slip properties as well as developing the cosmetic chemistry of talc and other additives. The proposed project will generate: a) simple but reliable test methods for measuring slip and shine, b) methods for control of the physical and chemical characteristics of talc blends, c) mathematical model(s) for property and process control, which is useful to improvement of the final talc properties and in-use service.Read moreRead less
Mechanism Of Anoxic Iron Acquisition In Pathogenic Bacteria
Funder
National Health and Medical Research Council
Funding Amount
$536,280.00
Summary
All organisms require iron for their survival, including all bacterial species. Bacterial pathogens growing in anaerobic environments, such as in our gut, gum, or tissue, sequester iron through the divalent iron transporter FeoB. We aim to divulge the mechanism of iron transport through FeoB by structural and functional studies, and thus provide a scaffold for a non-conventional antimicrobial target.
Discovery And Mechanisms Of Host Cell Factors In HIV Uncoating
Funder
National Health and Medical Research Council
Funding Amount
$635,098.00
Summary
HIV entry into the host cell involves release of its capsid, a protein shell protecting the viral genome. The capsid hijacks host proteins to cloak itself from cellular defenses while the cell has evolved sensors that can block viral infection. This proposal aims to discover proteins involved in this arms race between host and virus and decipher how they control capsid disassembly. This insight will help design new drugs against HIV infection and new ways to deliver genes for gene therapies.
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Prion-like Behaviour In Immunity: Super-sized Signalling Platforms?
Funder
National Health and Medical Research Council
Funding Amount
$611,995.00
Summary
Prions have been mostly associated with pathologies but recent discoveries show that prion-like behaviour may be beneficial, enhancing our immune response for example. To test this, we want to systematically explore all human proteins involved in the defence against pathogens, find new prion-like trends and probe their role in the innate immune response.
Australian Laureate Fellowships - Grant ID: FL180100134
Funder
Australian Research Council
Funding Amount
$3,007,316.00
Summary
Deep earth cycles of carbon, water and nitrogen. This project aims to understand the roles of carbon, water and nitrogen in the development of plate tectonics as drivers of mantle evolution. Through improved understanding of the impact of melting on the deep earth cycles of carbon, water and nitrogen, this project intends to better understand how key elements are enriched towards economically viable concentrations. This project will generate knowledge of long-term benefit for decision-making in ....Deep earth cycles of carbon, water and nitrogen. This project aims to understand the roles of carbon, water and nitrogen in the development of plate tectonics as drivers of mantle evolution. Through improved understanding of the impact of melting on the deep earth cycles of carbon, water and nitrogen, this project intends to better understand how key elements are enriched towards economically viable concentrations. This project will generate knowledge of long-term benefit for decision-making in the minerals exploration industry and key government agencies. The project will establish a new generation of Australian scientists with a deep interdisciplinary understanding of earth sciences, and pave the way for eventual unification of plate tectonic with climate systems.Read moreRead less
The structure and geochemistry of mineral interfaces in Earth's mantle. The interfaces between mineral grains are critical in determining rock properties and behaviour, yet we know little about them. This project uses emerging nano-technologies to establish the structure, chemistry and energy characteristics of interfaces in rocks from Earth’s mantle that control fundamental Earth processes such as plate tectonics and melting. The expected outcomes include a new understanding on one of the funda ....The structure and geochemistry of mineral interfaces in Earth's mantle. The interfaces between mineral grains are critical in determining rock properties and behaviour, yet we know little about them. This project uses emerging nano-technologies to establish the structure, chemistry and energy characteristics of interfaces in rocks from Earth’s mantle that control fundamental Earth processes such as plate tectonics and melting. The expected outcomes include a new understanding on one of the fundamental controls on rock properties and an enhanced ability to predict and model rock behaviour. The project provides research training in innovative research methodologies, will strengthen Australia’s leadership in nano-geoscience and will provide new methodologies for advanced rock characterisation.Read moreRead less
Characterising The Beta-catenin Nuclear Targeting Pathway In Cancer
Funder
National Health and Medical Research Council
Funding Amount
$485,081.00
Summary
Bowel cancer is caused by inherited gene mutations that cause build-up of beta-catenin protein in the cell nucleus. Bowel cancer is the second largest cause of cancer deaths in Australia. We aim to study the mechanisms controlling beta-catenin accumulation in the nucleus. We will characterise new signalling pathways that control movement and activity of beta-catenin in the nucleus. This will yield insights into the role of beta-catenin in cancer and possible targets for therapy.