Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Diamonds in ophiolite: recycling deep mantle into supra-subduction zones. This project aims to investigate whether the discovery of diamonds in oceanic rocks, known as ophiolites, is a global phenomenon. Even half a century after the introduction of plate tectonic theory, significant knowledge gaps remain regarding the fate of subducted lithosphere and Earth processes deep within the mantle. This project will use Australasian examples to test the hypothesis that diamonds are ubiquitous in the ma ....Diamonds in ophiolite: recycling deep mantle into supra-subduction zones. This project aims to investigate whether the discovery of diamonds in oceanic rocks, known as ophiolites, is a global phenomenon. Even half a century after the introduction of plate tectonic theory, significant knowledge gaps remain regarding the fate of subducted lithosphere and Earth processes deep within the mantle. This project will use Australasian examples to test the hypothesis that diamonds are ubiquitous in the mantle and occur widely in ophiolites. Results will have major implications for our understanding of how ocean crust grows and how rocks in the upper mantle form, as well as providing insight into how organic carbon is cycled from the seabed deep into the mantle before being returned back to Earth's surface.Read moreRead less
Phosphate stabilisation of metalliferous mine wastes: The key to solving a major environmental issue? Mine wastes represent the greatest proportion of solid waste produced by mankind. Unconstrained drainage from sulfide-rich mine wastes impacts on water, soil and sediment quality. This project will establish the scientific principles of phosphate stabilisation, which involves the addition of phosphate compounds to mine wastes and soils to permanently contain metals and acid. A solid understandin ....Phosphate stabilisation of metalliferous mine wastes: The key to solving a major environmental issue? Mine wastes represent the greatest proportion of solid waste produced by mankind. Unconstrained drainage from sulfide-rich mine wastes impacts on water, soil and sediment quality. This project will establish the scientific principles of phosphate stabilisation, which involves the addition of phosphate compounds to mine wastes and soils to permanently contain metals and acid. A solid understanding of this emerging technology is a prerequisite for any sustainable management of mine sites. The study will provide the foundation of future management tools needed by landholders, industry and regulators to remediate mined land and waste repositories.Read moreRead less
Exploring Scanning Ultrasound (SUS), A Novel Method To Treat And Prevent Neurodegenerative Disease
Funder
National Health and Medical Research Council
Funding Amount
$765,708.00
Summary
We developed a novel scanning ultrasound (SUS) protocol that clears toxic protein aggregates and restores memory function in mouse models of Alzheimer's disease (AD), without the need for therapeutic agents. Here we aim to determine whether SUS has preventative potential, whether there are synergistic effects, and whether a therapeutic antibody combined with SUS leads to an enhanced therapeutic outcome. Together this will guide the development of an ultrasound therapy in AD patients.
Deep time in the deep Earth: using trace element diffusivities to constrain durations of deep Earth processes. Evaluation of deep Earth resources requires knowing how long geological processes took, some record of which is often preserved by gradients in the chemical compositions of minerals. Experiments at very high temperatures and pressures will determine how this evidence can be used to constrain the durations of a rich variety of geological processes.
Biosensor Based Clinical-decision Support For Patients With Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$691,933.00
Summary
Heart Failure (HF) is a progressive disease and a major global public health concern. HF accounts for a substantial number of hospitalisations, major healthcare resource utilisation and costs. We aim to engineer biosensor platform to stratify the risk in HF patients will revolutionise current management of HF by providing the cardiologist information to risk stratify patients based on protein signature. This will lead to a substantial paradigm shift in clinical practice.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453436
Funder
Australian Research Council
Funding Amount
$448,284.00
Summary
An advanced electron microanalytical facility for South-East Queensland. Funding is requested to purchase an electron probe micro-analysis (EPMA) unit to be located at The University of Queensland and to upgrade and re-configure the scanning electron microscope facilities at the Queensland University of Technology. These integrated systems will be shared between the two institutions and will provide much needed infrastructure for several high profile and high performing groups. These groups incl ....An advanced electron microanalytical facility for South-East Queensland. Funding is requested to purchase an electron probe micro-analysis (EPMA) unit to be located at The University of Queensland and to upgrade and re-configure the scanning electron microscope facilities at the Queensland University of Technology. These integrated systems will be shared between the two institutions and will provide much needed infrastructure for several high profile and high performing groups. These groups include; Metallurgy, Materials, Earth Sciences, Chemistry, and Biomaterials. Acquisition of these facilities will complement the instrument mix at both institutions and will provide infrastructure that is necessary to sustain the leading edge research conducted by groups associated with this application.Read moreRead less
Polarized Trafficking Of E-cadherin In Epithelial Cells.
Funder
National Health and Medical Research Council
Funding Amount
$515,564.00
Summary
The cell adhesion protein E-cadherin is expressed in all epithelial tissues of the body where it has essential functions during development and in the adult in establishing and maintaining polarized cell monolayers. E-cadherin is also a vital tumour suppressor, its normal function guarantees that cells or even early tumours cannot metastasise; in contrast E-cadherin is always lost or malfunctions in malignant tumours. Earlier studies showed that E-cadherin is constantly moved, or trafficked, to ....The cell adhesion protein E-cadherin is expressed in all epithelial tissues of the body where it has essential functions during development and in the adult in establishing and maintaining polarized cell monolayers. E-cadherin is also a vital tumour suppressor, its normal function guarantees that cells or even early tumours cannot metastasise; in contrast E-cadherin is always lost or malfunctions in malignant tumours. Earlier studies showed that E-cadherin is constantly moved, or trafficked, to and from the surface of epithelial cells. This trafficking has dual roles, firstly in delivering newly-made E-cadherin to the surface where it functions and secondly, in regulating its adhesive function. Our research in this project is focussed on the molecules and intracellular compartments that control the delivery of E-cadherin to the cell surface. E-cadherin must be sorted in order to be delivered to the correct side of the cell. Having previously discovered the sorting signal in E-cadherin, we will now identify the cognate adaptor protein(s) that accomplish this sorting. New imaging techniques allow us to study protein trafficking inside live cells. Such studies have recently revealed that E-cadherin passes through a recycling endosome compartment on its way to the cell surface. This unexpected route, and the structure and role of the recycling endosome will now be studied in detail in live cells. Finally we will compare the sorting and trafficking of E-cadherin with the closely-related N-cadherin protein, to determine whether there are inherent differences in their trafficking that could explain their opposite roles in tumour cells, where N-cadherin is substituted for E-cadherin and allows metastatic behaviour. These studies will provide important information for understanding the adhesive and tumour suppressive roles of E-cadherin. In addition our findings will generate information fundamental to our understanding of cell polarity and protein sorting.Read moreRead less