Platelet Glycoprotein Proteolysis: Novel Mechanisms And Risk Factors
Funder
National Health and Medical Research Council
Funding Amount
$441,473.00
Summary
Platelets are the richest source of amyloid precursor protein (APP) in the body. Platelet ADAM10 regulates both the expression and function of the major platelet collagen receptor GPVI, and protective APP processing. Coagulation protein Factor X has a role in activation of ADAM10. This activation is disrupted in blood that has been treated with direct oral anticoagulant (DOAC) rivaroxaban. This grant will investigate the implications for people taking rivaroxaban on regulation of APP and GPVI.
Experimental constraints on Platinum-Group Element geochemistry: developing lithogeochemical exploration tools for nickel-sulfides in mafic and ultramafic systems. Nickel contributes approximately $2 billion per year to Australia's export income. Currently 80% of that is coming from sulfide deposits, which are expected to be exhausted within thirty years barring significant new discoveries. Discovery rates have been declining for two decades, as the 'easy' targets have been found, despite a broa ....Experimental constraints on Platinum-Group Element geochemistry: developing lithogeochemical exploration tools for nickel-sulfides in mafic and ultramafic systems. Nickel contributes approximately $2 billion per year to Australia's export income. Currently 80% of that is coming from sulfide deposits, which are expected to be exhausted within thirty years barring significant new discoveries. Discovery rates have been declining for two decades, as the 'easy' targets have been found, despite a broad increase in nickel exploration expenditure to current levels of around $50 million per year. There is a pressing need for new data sets and techniques to allow industry to target new discoveries based on limited drill sampling of potential host rocks. This project forms part of a broader program to harness the igneous geochemistry of the platinum group elements as a powerful pathfinder in nickel exploration.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100030
Funder
Australian Research Council
Funding Amount
$980,000.00
Summary
Returning Western Australian characterisation capabilities to the cutting edge: high resolution analytical transmission electron microscopy. From the design of future electronic devices to understanding the formation of valuable deposits of gold and iron, the atomic scale structure and composition of materials plays an important role. The electron microscope will aid internationally-recognised WA-based groups conducting high impact research underpinning the Australian economy.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100103
Funder
Australian Research Council
Funding Amount
$547,000.00
Summary
Australian Virtual Experimental Laboratory: a multimode geoscience facility. Australian virtual experimental laboratory: a multimode geoscience facility:
This project aims to establish seven types of high-pressure equipment to form a multi-node experimental laboratory at four locations across Australia. Experiments conducted at the high pressures and temperatures of the internal Earth form the basis of our knowledge about the physical and chemical processes that drive geological processes such ....Australian Virtual Experimental Laboratory: a multimode geoscience facility. Australian virtual experimental laboratory: a multimode geoscience facility:
This project aims to establish seven types of high-pressure equipment to form a multi-node experimental laboratory at four locations across Australia. Experiments conducted at the high pressures and temperatures of the internal Earth form the basis of our knowledge about the physical and chemical processes that drive geological processes such as plate tectonics, melting to form volcanoes, and the formation and movement of fluids that concentrate precious metals into valuable ore deposits. The new facility may enable major advances in fields such as mantle geodynamics and element transport in fluids, improving our understanding of internal Earth processes and ore deposit formation and location. It also includes portable systems, which can be used in synchrotron applications.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100035
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre in Critical Resources for the Future. The proposed ARC Training Centre in Critical Resources aims to train the next generation of geoscientists needed to enable resourcing of the transition to a high-tech, clean energy society. Training of PhD students and postdoctoral scientists will primarily focus on bridging the gap between mineral systems science, mineral exploration protocols and ore processing/metallurgical extraction. This will provide geoscientists with an essential ....ARC Training Centre in Critical Resources for the Future. The proposed ARC Training Centre in Critical Resources aims to train the next generation of geoscientists needed to enable resourcing of the transition to a high-tech, clean energy society. Training of PhD students and postdoctoral scientists will primarily focus on bridging the gap between mineral systems science, mineral exploration protocols and ore processing/metallurgical extraction. This will provide geoscientists with an essential understanding of the whole value chain of the critical resources of the future.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100006
Funder
Australian Research Council
Funding Amount
$1,060,000.00
Summary
Ultra-high resolution focussed ion beam facility for Western Australia. Ultra-high resolution focussed ion beam facility: An ultra-high resolution dual beam facility (incorporating ion and electron beams) will provide 3D imaging, site-specific analysis and nano-machining to a wide range of internationally recognised Australian researchers across a broad spectrum of disciplines in the geosciences, engineering, biological and physical sciences. Providing critically needed access to this world-clas ....Ultra-high resolution focussed ion beam facility for Western Australia. Ultra-high resolution focussed ion beam facility: An ultra-high resolution dual beam facility (incorporating ion and electron beams) will provide 3D imaging, site-specific analysis and nano-machining to a wide range of internationally recognised Australian researchers across a broad spectrum of disciplines in the geosciences, engineering, biological and physical sciences. Providing critically needed access to this world-class infrastructure is expected to advance international competitiveness, leading to high-impact outcomes in smart materials, nanotechnology, bioscience, and geoscience, including support for the Australian resources sector.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100236
Funder
Australian Research Council
Funding Amount
$180,000.00
Summary
Facilities for spectroscopy and diffraction at high pressures. The provision of infrastructure for the study of novel materials under high pressures will enhance Australia's capability in creating new materials and in creating new devices that meet needs in communication, environment and medicine applications. The new facility will enable researchers to understand the response of structures to extreme pressures and will exploit the unique capabilities of the synchrotron light.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100157
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information th ....Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information that is not easily obtainable with other approaches. The project will enable Australian researchers to image and analyse the full complexity of biological systems, potentially transforming cell biology, drug development and understanding the molecular basis of disease. It will also demonstrate how the capacity of microscopy facilities can be enhanced and bias in imaging data reduced by automating data acquisition and mining of image-based data.Read moreRead less