Experimental constraints on Platinum-Group Element geochemistry: developing lithogeochemical exploration tools for nickel-sulfides in mafic and ultramafic systems. Nickel contributes approximately $2 billion per year to Australia's export income. Currently 80% of that is coming from sulfide deposits, which are expected to be exhausted within thirty years barring significant new discoveries. Discovery rates have been declining for two decades, as the 'easy' targets have been found, despite a broa ....Experimental constraints on Platinum-Group Element geochemistry: developing lithogeochemical exploration tools for nickel-sulfides in mafic and ultramafic systems. Nickel contributes approximately $2 billion per year to Australia's export income. Currently 80% of that is coming from sulfide deposits, which are expected to be exhausted within thirty years barring significant new discoveries. Discovery rates have been declining for two decades, as the 'easy' targets have been found, despite a broad increase in nickel exploration expenditure to current levels of around $50 million per year. There is a pressing need for new data sets and techniques to allow industry to target new discoveries based on limited drill sampling of potential host rocks. This project forms part of a broader program to harness the igneous geochemistry of the platinum group elements as a powerful pathfinder in nickel exploration.Read moreRead less
A Direct Approach to Crystal Structure Determination - a solution to the phase problem. The purpose of this research is to determine the positions of atoms in crystals and nano-crystals. We have developed a theory that shows how to extract all of the information required to determine atomic positions from such crystals and we have carried through initial successful tests on simple materials. In particular, we have found that crystallographic phase, hitherto not directly measurable, can in fact b ....A Direct Approach to Crystal Structure Determination - a solution to the phase problem. The purpose of this research is to determine the positions of atoms in crystals and nano-crystals. We have developed a theory that shows how to extract all of the information required to determine atomic positions from such crystals and we have carried through initial successful tests on simple materials. In particular, we have found that crystallographic phase, hitherto not directly measurable, can in fact be extracted uniquely from a single electron diffraction pattern. This constitutes a solution to the phase problem in crystallography. It is now our aim to develop this method into a routine technique.Read moreRead less
Order-disorder behaviour in Bi-tellurides: a tool to monitor gold scavenging by Bi-Te melts. This project addresses a group of minerals (bismuth tellurides) that are often part of the exotic assemblages present in gold deposits, yet their potential to model the gold-forming processes is only recently apparent. These minerals also have the capacity to record their genetic history due to crystal modularity. Materials scientists target the analogous synthetic compounds because of the same structura ....Order-disorder behaviour in Bi-tellurides: a tool to monitor gold scavenging by Bi-Te melts. This project addresses a group of minerals (bismuth tellurides) that are often part of the exotic assemblages present in gold deposits, yet their potential to model the gold-forming processes is only recently apparent. These minerals also have the capacity to record their genetic history due to crystal modularity. Materials scientists target the analogous synthetic compounds because of the same structural modularity for applications in nanotechnology. The dataset on the mineral compounds, using the geological environment as a natural laboratory, will serve materials science research, as much as delivering key information relevant to understanding the reasons for gold enrichment in economically important types of ores. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989986
Funder
Australian Research Council
Funding Amount
$230,000.00
Summary
Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims ....Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims to provide outstanding opportunities for the training of research students, expanding research in the fields of materials, minerals, geological, environmental and forensic science enabling to maintain Australia's lead and competitiveness in cutting edge research and technology. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347955
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
A Cell Sorter Facility for Neuroscience and Related Biotechnology. Neuroscience is entering an era of accelerated discovery in which Queensland neuroscientists can excel if they gain leadership in key technologies. One critical technology is the ability to obtain specific cell populations from various parts of the nervous system in sufficient quantity and purity to enable their accurate examination by gene array, proteomics and physiological techniques. The aim is to establish the world's first ....A Cell Sorter Facility for Neuroscience and Related Biotechnology. Neuroscience is entering an era of accelerated discovery in which Queensland neuroscientists can excel if they gain leadership in key technologies. One critical technology is the ability to obtain specific cell populations from various parts of the nervous system in sufficient quantity and purity to enable their accurate examination by gene array, proteomics and physiological techniques. The aim is to establish the world's first cell-sorting facility dedicated to the production of nerve cells suitable for molecular characterization and screening, providing the basis for identifying key molecules regulating brain function, ageing and repair of great importance to the biotechnology/pharmaceutical industry.Read moreRead less
Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not re ....Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not respond to the current TNF treatments. Improved anti-TNF strategies would provide enhanced health outcomes and welcome relief to many Australians. In addition, the economic benefit of the TNF market is very substantial. Therefore the potential impact of this research is very high both for health care and economical potential.Read moreRead less
The molecular mechanism of retromer and sorting nexin function in endosomal membrane trafficking. The proposed research represents breakthrough science that will lead to a fundamental understanding at the molecular level of the structure and assembly of the retromer complex and how it regulates sorting of receptors in the endosomal system. It will provide excellent research training for top graduate students and post-doctoral scientists in multidisciplinary methods that constitute state-of the- ....The molecular mechanism of retromer and sorting nexin function in endosomal membrane trafficking. The proposed research represents breakthrough science that will lead to a fundamental understanding at the molecular level of the structure and assembly of the retromer complex and how it regulates sorting of receptors in the endosomal system. It will provide excellent research training for top graduate students and post-doctoral scientists in multidisciplinary methods that constitute state-of the-art structural and molecular cell biology research. By addressing an area of great interest internationally the project will have the capacity to increase Australia's knowledge base and strengthen it's reputation for research excellence.Read moreRead less
Endosomal Protein Transport: From Molecular Structures to Biological Function. Intracellular transport of biomolecules through the endosomal organelle is critical for normal cellular processes such as signalling, homoeostasis and development. Defects in this fundamental process and subversion of it by bacterial and viral pathogens also lead to many different human diseases. This project will build on Australia's strong programme of structural and cellular biology research to develop key insights ....Endosomal Protein Transport: From Molecular Structures to Biological Function. Intracellular transport of biomolecules through the endosomal organelle is critical for normal cellular processes such as signalling, homoeostasis and development. Defects in this fundamental process and subversion of it by bacterial and viral pathogens also lead to many different human diseases. This project will build on Australia's strong programme of structural and cellular biology research to develop key insights into endosomal trafficking at the molecular level. Outcomes from this work will place Australia at the forefront of international efforts to understand this essential biological process and will have important implications for future design of pharmaceuticals.Read moreRead less